北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Time to positivity of blood culture can predict different Candida species instead of pathogen concentration in candidemia
作者: Huang, L.1; Zhang, Y. Y.2; Sun, L. Y.1
刊名: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
发表日期: 2013-07-01
DOI: 10.1007/s10096-013-1826-8
卷: 32, 期:7, 页:917-922
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases ; Microbiology
研究领域[WOS]: Infectious Diseases ; Microbiology
关键词[WOS]: ESCHERICHIA-COLI BACTEREMIA ; INVASIVE CANDIDIASIS ; BACTEC 9240 ; IDENTIFICATION ; EPIDEMIOLOGY ; SURVEILLANCE ; FLUCONAZOLE ; INFECTIONS ; MORTALITY ; FUNGEMIA
英文摘要:

The aim of this study was to systematically evaluate the predictive value of time to positivity (TTP) in candidemia. All first episodes of candidemic patients admitted to our hospital between January 2008 and July 2012 were recorded retrospectively. We analyzed the relationship between TTP, identification of Candida species, antifungal agent susceptibility, and patients′ clinical characteristics (30-day mortality, underlying diseases, and associated risk factors). TTP of simulated blood culture with equal inoculum amounts of different Candida species was determined. We included 87 patients during the study period, with a mean TTP of 43.47 +/- 19.51 h. TTP of C. glabrata was significantly longer (p < 0.001) and TTP of C. tropicalis was significantly shorter (p < 0.001) than that of other Candida species. Receiver operating characteristic (ROC) curve analysis showed that TTP can predict C. glabrata (with the cut-off value of > 45.17 h) and C. tropicalis (with the cut-off value of a parts per thousand currency sign33.17 h) in candidemia with good sensitivity and specificity. No statistically significant relationship was found between TTP, antifungal agent susceptibility, and patients′ clinical characteristics (p > 0.05). TTP was not a risk factor associated with mortality (p > 0.05). The TTP result in simulated blood culture was in accordance with that of the included patients. TTP has been demonstrated to be helpful to differentiate C. glabrata and C. tropicalis from other Candida species in candidemia, and it is not associated with antifungal agent susceptibility and patients′ clinical characteristics. TTP cannot predict pathogen concentration in the blood of candidemic patients.

语种: 英语
所属项目编号: 81201338
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000320338900010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58735
Appears in Collections:北京大学第一临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100871, Peoples R China
2.Wannan Med Coll, Yijishan Hosp, Dept Clin Lab, Wuxi, Anhui, Peoples R China

Recommended Citation:
Huang, L.,Zhang, Y. Y.,Sun, L. Y.. Time to positivity of blood culture can predict different Candida species instead of pathogen concentration in candidemia[J]. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY &amp; INFECTIOUS DISEASES,2013,32(7):917-922.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Huang, L.]'s Articles
[Zhang, Y. Y.]'s Articles
[Sun, L. Y.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Huang, L.]‘s Articles
[Zhang, Y. Y.]‘s Articles
[Sun, L. Y.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace