IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Time to positivity of blood culture can predict different Candida species instead of pathogen concentration in candidemia
Huang, L.1; Zhang, Y. Y.2; Sun, L. Y.1
刊名EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
2013-07-01
DOI10.1007/s10096-013-1826-8
32期:7页:917-922
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases ; Microbiology
研究领域[WOS]Infectious Diseases ; Microbiology
关键词[WOS]ESCHERICHIA-COLI BACTEREMIA ; INVASIVE CANDIDIASIS ; BACTEC 9240 ; IDENTIFICATION ; EPIDEMIOLOGY ; SURVEILLANCE ; FLUCONAZOLE ; INFECTIONS ; MORTALITY ; FUNGEMIA
英文摘要

The aim of this study was to systematically evaluate the predictive value of time to positivity (TTP) in candidemia. All first episodes of candidemic patients admitted to our hospital between January 2008 and July 2012 were recorded retrospectively. We analyzed the relationship between TTP, identification of Candida species, antifungal agent susceptibility, and patients′ clinical characteristics (30-day mortality, underlying diseases, and associated risk factors). TTP of simulated blood culture with equal inoculum amounts of different Candida species was determined. We included 87 patients during the study period, with a mean TTP of 43.47 +/- 19.51 h. TTP of C. glabrata was significantly longer (p < 0.001) and TTP of C. tropicalis was significantly shorter (p < 0.001) than that of other Candida species. Receiver operating characteristic (ROC) curve analysis showed that TTP can predict C. glabrata (with the cut-off value of > 45.17 h) and C. tropicalis (with the cut-off value of a parts per thousand currency sign33.17 h) in candidemia with good sensitivity and specificity. No statistically significant relationship was found between TTP, antifungal agent susceptibility, and patients′ clinical characteristics (p > 0.05). TTP was not a risk factor associated with mortality (p > 0.05). The TTP result in simulated blood culture was in accordance with that of the included patients. TTP has been demonstrated to be helpful to differentiate C. glabrata and C. tropicalis from other Candida species in candidemia, and it is not associated with antifungal agent susceptibility and patients′ clinical characteristics. TTP cannot predict pathogen concentration in the blood of candidemic patients.

语种英语
WOS记录号WOS:000320338900010
项目编号81201338
资助机构National Natural Science Foundation of China
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58735
专题北京大学第一临床医学院
北京大学第二临床医学院_药剂科
作者单位1.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100871, Peoples R China
2.Wannan Med Coll, Yijishan Hosp, Dept Clin Lab, Wuxi, Anhui, Peoples R China
推荐引用方式
GB/T 7714
Huang, L.,Zhang, Y. Y.,Sun, L. Y.. Time to positivity of blood culture can predict different Candida species instead of pathogen concentration in candidemia[J]. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY &amp; INFECTIOUS DISEASES,2013,32(7):917-922.
APA Huang, L.,Zhang, Y. Y.,&Sun, L. Y..(2013).Time to positivity of blood culture can predict different Candida species instead of pathogen concentration in candidemia.EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES,32(7),917-922.
MLA Huang, L.,et al."Time to positivity of blood culture can predict different Candida species instead of pathogen concentration in candidemia".EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 32.7(2013):917-922.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Huang, L.]的文章
[Zhang, Y. Y.]的文章
[Sun, L. Y.]的文章
百度学术
百度学术中相似的文章
[Huang, L.]的文章
[Zhang, Y. Y.]的文章
[Sun, L. Y.]的文章
必应学术
必应学术中相似的文章
[Huang, L.]的文章
[Zhang, Y. Y.]的文章
[Sun, L. Y.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。