IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
The appearance of myofibroblasts and the disappearance of CD34-positive stromal cells in the area adjacent to xanthogranulomatous foci of chronic cholecystitis
Kuroda, N; Guo, L; Miyazaki, E; Hamauzu, T; Toi, M; Hiroi, M; Enzan, H
关键词chronic cholecystitis myofibroblast xanthogranulomatous foci CD34-positive stromal cell
刊名HISTOLOGY AND HISTOPATHOLOGY
2005
20期:1页:127-133
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Pathology
研究领域[WOS]Cell Biology ; Pathology
关键词[WOS]DENDRITIC INTERSTITIAL-CELLS ; POSITIVE RETICULAR NETWORK ; SMOOTH-MUSCLE ; H-CALDESMON ; INTRALOBULAR FIBROBLASTS ; PHENOTYPIC MODULATION ; PANCREATIC LESIONS ; CD34(+) FIBROCYTES ; GASTRIC CARCINOMAS ; GAP-JUNCTIONS
英文摘要

We investigated the distribution of myofibroblasts and CD34-positive stromal cells in normal gallbladder and its pathological conditions (cholecystitis, n=25) using immunohistochemistry and in situ hybridization. In the wall of normal gallbladder, myofibroblasts were generally absent from all layers, but many CD34-positive stromal cells were observed in the connective tissue layer. In chronic cholecystitis with mild perimuscular fibrosis, a small to moderate number of myofibroblasts appeared in the mucosal layer. In chronic cholecystitis with marked perimuscular fibrosis, a small to large number of myofibroblasts appeared predominantly in the connective tissue layer, whereas the number of CD34-positive stromal cells decreased at the same location, although the number of myofibroblasts increased. In chronic cholecystitis with xanthogranulomatous foci, a small to large number of myofibroblasts were observed in the periphery of the xanthogranulomatous reaction and adjacent area. In contrast, CD34-positive stromal cells were completely absent or were limited to the area just around the xanthogranulomatous reaction. Induction of collagen type I and III mRNA was predominantly observed in the cytoplasm of myofibroblasts associated with the marked fibrosis, which consisted primarily of mature collagen fibers, and in the cytoplasm of myofibroblasts around the xanthogranulomatous reaction, respectively. Finally, myofibroblasts were observed in all subtypes. The increased number of myofibroblasts was most prominent in the connective tissue layer of chronic cholecystitis with marked perimuscular fibrosis or in the area adjacent to xanthogranulomatous foci of chronic cholecystitis. Under these conditions, CD34-positive stromal cells tended to disappear from the connective tissue layer, which exhibited an increase in myofibroblasts.

语种英语
WOS记录号WOS:000225968900016
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58736
Collection北京大学基础医学院_病理学系
作者单位1.Kochi Univ, Kochi Med Sch, Dept Pathol, Program Bioregulat & Genet, Nankoku, Kochi 7838505, Japan
2.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Kuroda, N,Guo, L,Miyazaki, E,et al. The appearance of myofibroblasts and the disappearance of CD34-positive stromal cells in the area adjacent to xanthogranulomatous foci of chronic cholecystitis[J]. HISTOLOGY AND HISTOPATHOLOGY,2005,20(1):127-133.
APA Kuroda, N.,Guo, L.,Miyazaki, E.,Hamauzu, T.,Toi, M.,...&Enzan, H.(2005).The appearance of myofibroblasts and the disappearance of CD34-positive stromal cells in the area adjacent to xanthogranulomatous foci of chronic cholecystitis.HISTOLOGY AND HISTOPATHOLOGY,20(1),127-133.
MLA Kuroda, N,et al."The appearance of myofibroblasts and the disappearance of CD34-positive stromal cells in the area adjacent to xanthogranulomatous foci of chronic cholecystitis".HISTOLOGY AND HISTOPATHOLOGY 20.1(2005):127-133.
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