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学科主题基础医学
Curcumin Protects PC12 Cells from Corticosterone-Induced Cytotoxicity: Possible Involvement of the ERK1/2 Pathway
Gao, Min; Zhou, Hong; Li, Xuejun
刊名BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
2009-03-01
DOI10.1111/j.1742-7843.2008.00369.x
104期:3页:236-240
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]Pharmacology & Pharmacy ; Toxicology
关键词[WOS]SIGNAL-TRANSDUCTION PATHWAYS ; KINASE SIGNAL ; CHRONIC STRESS ; DEPRESSION ; NEURONS ; ANTIDEPRESSANTS ; GLUCOCORTICOIDS ; HIPPOCAMPUS ; ACTIVATION ; EXPRESSION
英文摘要

Antiglucocorticoid therapy in depressed patients is effective, which indicates that glucocorticoids play a key role in the occurrence of depression. Our previous work demonstrated the efficacy of curcumin in treating depression in rat and mouse models. We characterized the protective effects of curcumin against corticosterone-induced cytotoxicity in PC12 cells and explored the mechanisms of these protective effects in association with the phosphorylation and expression of ERK1/2 in PC12 cells. MTT assay showed that curcumin significantly protected PC12 cells from corticosterone-induced cytotoxicity. Curcumin at concentrations from 10(-8) to 10(-6) M rescued PC12 cells from corticosterone-induced cytotoxicity. Cell viability was increased more than 20% with curcumin treatment. Western blot analysis showed that corticosterone increased ERK1/2 phosphorylation in PC12 cells and curcumin 10(-9) M to 10(-6) M significantly inhibited corticosterone-induced ERK1/2 phosphorylation in PC12 cells in a dose-dependent manner. These results suggest that curcumin is able to protect PC12 cells which may be associated with inhibition of ERK phosphorylation.

语种英语
WOS记录号WOS:000263329000009
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58737
专题北京大学基础医学院_药理学系
北京大学基础医学院
作者单位Peking Univ, Dept Pharmacol, Sch Basic Med Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
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GB/T 7714
Gao, Min,Zhou, Hong,Li, Xuejun. Curcumin Protects PC12 Cells from Corticosterone-Induced Cytotoxicity: Possible Involvement of the ERK1/2 Pathway[J]. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY,2009,104(3):236-240.
APA Gao, Min,Zhou, Hong,&Li, Xuejun.(2009).Curcumin Protects PC12 Cells from Corticosterone-Induced Cytotoxicity: Possible Involvement of the ERK1/2 Pathway.BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY,104(3),236-240.
MLA Gao, Min,et al."Curcumin Protects PC12 Cells from Corticosterone-Induced Cytotoxicity: Possible Involvement of the ERK1/2 Pathway".BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 104.3(2009):236-240.
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