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学科主题: 基础医学
题名:
Curcumin Protects PC12 Cells from Corticosterone-Induced Cytotoxicity: Possible Involvement of the ERK1/2 Pathway
作者: Gao, Min; Zhou, Hong; Li, Xuejun
刊名: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
发表日期: 2009-03-01
DOI: 10.1111/j.1742-7843.2008.00369.x
卷: 104, 期:3, 页:236-240
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ; Toxicology
关键词[WOS]: SIGNAL-TRANSDUCTION PATHWAYS ; KINASE SIGNAL ; CHRONIC STRESS ; DEPRESSION ; NEURONS ; ANTIDEPRESSANTS ; GLUCOCORTICOIDS ; HIPPOCAMPUS ; ACTIVATION ; EXPRESSION
英文摘要:

Antiglucocorticoid therapy in depressed patients is effective, which indicates that glucocorticoids play a key role in the occurrence of depression. Our previous work demonstrated the efficacy of curcumin in treating depression in rat and mouse models. We characterized the protective effects of curcumin against corticosterone-induced cytotoxicity in PC12 cells and explored the mechanisms of these protective effects in association with the phosphorylation and expression of ERK1/2 in PC12 cells. MTT assay showed that curcumin significantly protected PC12 cells from corticosterone-induced cytotoxicity. Curcumin at concentrations from 10(-8) to 10(-6) M rescued PC12 cells from corticosterone-induced cytotoxicity. Cell viability was increased more than 20% with curcumin treatment. Western blot analysis showed that corticosterone increased ERK1/2 phosphorylation in PC12 cells and curcumin 10(-9) M to 10(-6) M significantly inhibited corticosterone-induced ERK1/2 phosphorylation in PC12 cells in a dose-dependent manner. These results suggest that curcumin is able to protect PC12 cells which may be associated with inhibition of ERK phosphorylation.

语种: 英语
所属项目编号: 30171090 ; 30270528 ; 30572202 ; 30772571 ; 2004CB518902 ; B0700 ; 985
项目资助者: National Natural Science Foundation of China ; Ministry of Science and Technology in China ; Ministry of Education of China
WOS记录号: WOS:000263329000009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58737
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: Peking Univ, Dept Pharmacol, Sch Basic Med Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Gao, Min,Zhou, Hong,Li, Xuejun. Curcumin Protects PC12 Cells from Corticosterone-Induced Cytotoxicity: Possible Involvement of the ERK1/2 Pathway[J]. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY,2009,104(3):236-240.
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