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学科主题: 基础医学
题名:
Hepatocyte growth factor promotes proliferation and migration in immortalized progenitor cells
作者: Lan, Feng1,2; Xu, Jinchong1,2; Zhang, Xiaoyan1,2; Wong, Vincent Wai-Sun1,3; Li, Xiaoxia1,2; Lu, Aili1,2; Lu, Wenjing1,2; Shen, Li1,2; Li, Lingsong1,2
关键词: dopaminergic progenitor cells ; hepatocyte growth factor ; immortalization ; migration ; proliferation
刊名: NEUROREPORT
发表日期: 2008-05-07
卷: 19, 期:7, 页:765-769
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: FACTOR-SCATTER FACTOR ; EMBRYONIC STEM-CELLS ; DOPAMINERGIC-NEURONS ; PARKINSONS-DISEASE ; MAMMALIAN BRAIN ; FACTOR HGF ; IN-VITRO ; CHEMOATTRACTANT ; TELOMERASE ; PKC
英文摘要:

Hepatocyte growth factor (HGF) and its receptor c-Met are widely expressed in the developing and adult brain. However, little is known about the role of HGF during the development of the human dopaminergic neuronal system. We have established telomerase-immortalized dopaminergic progenitor cells isolated from the fetal striatum that express markers for neural progenitor cells and tyrosine hydroxylase. We show that the cells were able to differentiate into dopaminergic neurons and release dopamine. Exogenous HGF-induced proliferation was inhibited by U0126, whereas migration was completely blocked by LY294002. Study demonstrates that HGF regulates the proliferation and migration of dopaminergic progenitor cells. Modulating dopaminergic progenitor cells in the striatum may prove to be a new approach for treating Parkinson′s disease.

语种: 英语
WOS记录号: WOS:000255530600012
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58743
Appears in Collections:基础医学院_北京大学干细胞研究中心_期刊论文

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作者单位: 1.Peking Univ, Stem Cell Res Ctr, Dept Cell Biol, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100083, Peoples R China
3.Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Lan, Feng,Xu, Jinchong,Zhang, Xiaoyan,et al. Hepatocyte growth factor promotes proliferation and migration in immortalized progenitor cells[J]. NEUROREPORT,2008,19(7):765-769.
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