学科主题基础医学
Hepatocyte growth factor promotes proliferation and migration in immortalized progenitor cells
Lan, Feng1,2; Xu, Jinchong1,2; Zhang, Xiaoyan1,2; Wong, Vincent Wai-Sun1,3; Li, Xiaoxia1,2; Lu, Aili1,2; Lu, Wenjing1,2; Shen, Li1,2; Li, Lingsong1,2
关键词dopaminergic progenitor cells hepatocyte growth factor immortalization migration proliferation
刊名NEUROREPORT
2008-05-07
19期:7页:765-769
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]FACTOR-SCATTER FACTOR ; EMBRYONIC STEM-CELLS ; DOPAMINERGIC-NEURONS ; PARKINSONS-DISEASE ; MAMMALIAN BRAIN ; FACTOR HGF ; IN-VITRO ; CHEMOATTRACTANT ; TELOMERASE ; PKC
英文摘要

Hepatocyte growth factor (HGF) and its receptor c-Met are widely expressed in the developing and adult brain. However, little is known about the role of HGF during the development of the human dopaminergic neuronal system. We have established telomerase-immortalized dopaminergic progenitor cells isolated from the fetal striatum that express markers for neural progenitor cells and tyrosine hydroxylase. We show that the cells were able to differentiate into dopaminergic neurons and release dopamine. Exogenous HGF-induced proliferation was inhibited by U0126, whereas migration was completely blocked by LY294002. Study demonstrates that HGF regulates the proliferation and migration of dopaminergic progenitor cells. Modulating dopaminergic progenitor cells in the striatum may prove to be a new approach for treating Parkinson′s disease.

语种英语
WOS记录号WOS:000255530600012
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58743
专题北京大学基础医学院_北京大学干细胞研究中心
北京大学基础医学院
作者单位1.Peking Univ, Stem Cell Res Ctr, Dept Cell Biol, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100083, Peoples R China
3.Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China
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GB/T 7714
Lan, Feng,Xu, Jinchong,Zhang, Xiaoyan,et al. Hepatocyte growth factor promotes proliferation and migration in immortalized progenitor cells[J]. NEUROREPORT,2008,19(7):765-769.
APA Lan, Feng.,Xu, Jinchong.,Zhang, Xiaoyan.,Wong, Vincent Wai-Sun.,Li, Xiaoxia.,...&Li, Lingsong.(2008).Hepatocyte growth factor promotes proliferation and migration in immortalized progenitor cells.NEUROREPORT,19(7),765-769.
MLA Lan, Feng,et al."Hepatocyte growth factor promotes proliferation and migration in immortalized progenitor cells".NEUROREPORT 19.7(2008):765-769.
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