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学科主题: 临床医学
题名:
The Clinical and Immune Characteristics of Patients with Hepatitis-Associated Aplastic Anemia in China
作者: Wang, Huaquan1; Tu, Meifeng2; Fu, Rong1; Wu, Yuhong1; Liu, Hong1; Xing, Limin1; Shao, Zonghong1
刊名: PLOS ONE
发表日期: 2014-05-20
DOI: 10.1371/journal.pone.0098142
卷: 9, 期:5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: VIRAL-HEPATITIS ; EPIDEMIOLOGY ; VIRUS ; CELLS
英文摘要:

Hepatitis-associated aplastic anemia (HAAA) is a variant of severe aplastic anemia (SAA) in which bone marrow failure follows an acute attack of hepatitis. Its pathogenesis is poorly understood. We investigated the prevalence of HAAA among cases of newly diagnosed SAA presenting to our hospital between January 1998 and February 2013, and analyzed the clinical and immune characteristics of HAAA and non-hepatitis-associated SAA (non-HASAA) patients. The prevalence of HAAA among cases of SAA was 3.8% (36/949), and the majority of patients (33/36) were seronegative for a known hepatitis virus. Compared with non-HASAA patients, HAAA patients had a larger proportion of CD8+ T cells, a lower ratio of CD4+/CD8+ T cells, and a smaller proportion of CD4+CD25+ regulatory T cells. There was no significant difference in peripheral blood count, bone marrow cellularity, or the number of blood transfusions received between HAAA and non-HASAA patients. HAAA patients had a higher early infection rate and more infection-related mortality in the first 2 years after diagnosis than non-HASAA patients, and their 2-year survival rate was lower. The results demonstrate that HAAA patients have a more severe T cell imbalance and a poorer prognosis than non-HASAA patients.

语种: 英语
所属项目编号: 30971286 ; 30971285 ; 81170472 ; 81370607
项目资助者: Natural Science Foundation of China
WOS记录号: WOS:000339563400101
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58747
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Tianjin Med Univ, Gen Hosp, Dept Hematol, Tianjin, Peoples R China
2.Peking Univ, Sch Oncol, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept Lymphoma,Beijing Canc Hosp & Ins, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Huaquan,Tu, Meifeng,Fu, Rong,et al. The Clinical and Immune Characteristics of Patients with Hepatitis-Associated Aplastic Anemia in China[J]. PLOS ONE,2014,9(5).
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