IR@PKUHSC  > 北京大学口腔医学院  > 口腔病理科
学科主题口腔医学
Clinicopathological characteristics of immunoglobulin G4-related sialadenitis
Li, Wei1; Chen, Yan2; Sun, Zhi-Peng3; Cai, Zhi-Gang1; Li, Tong-Tong1; Zhang, Lei1; Huang, Min-Xian1; Hua, Hong4; Li, Mei5; Hong, Xia1; Su, Jia-Zeng1; Zhang, Zhu-Yan3; Liu, Yan-Ying6; He, Jing6; Li, Zhan-Guo6; Gao, Yan2; Yu, Guang-Yan1
刊名ARTHRITIS RESEARCH & THERAPY
2015-07-21
DOI10.1186/s13075-015-0698-y
17
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Rheumatology
关键词[WOS]CHRONIC SCLEROSING SIALADENITIS ; IGG4-RELATED SYSTEMIC-DISEASE ; AUTOIMMUNE PANCREATITIS ; MIKULICZS-DISEASE ; SJOGRENS-SYNDROME ; SERUM IGG4 ; CRITERIA ; INFILTRATION ; TUMOR
英文摘要

Introduction: Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized fibro-inflammatory condition. Forty-two cases with immunoglobulin G4-related sialadenitis (IgG4-RS) confirmed by histopathological and immunohistochemical assessment were studied to clarify the clinicopathologic characteristics of the salivary glands involved in IgG4-RS, especially the relationship between the histopathologic features and function of salivary glands or serum levels of IgG4.

Methods: Clinical, serologic, imaging and histopathological data of these cases were analyzed. CT volumes of submandibular, parotid, and lacrimal glands were calculated. The saliva flow rate was measured. Scintigraphy with 99mTc-pertechnetate was undertaken in 31 cases, and the concentration index (CI) and secretion index (SI) was calculated. Relationships between fibrosis severity and salivary gland function or serum IgG4 levels were analyzed.

Results: The first symptom was swelling of bilateral submandibular or lacrimal glands. Physical examination showed multiple bilateral major salivary glands (including sublingual and accessory parotid glands) and lacrimal glands were enlarged in IgG4 RS. Multiple enlarged cervical lymph nodes were noted in 30 patients. Saliva flow at rest was lower than normal in 34 cases; stimulated saliva flow was lower than normal in 15 cases. Secretory function was reduced more severely in the submandibular glands than in the parotid glands. Serum levels of IgG4 were elevated in 95.2% of cases and 78.6% patients had increased IgE levels. Serum IgG4 level was higher and saliva secretion lower as glandular fibrosis increased.

Conclusions: Prominent changes in the morphology, histology, immunohistochemistry and secretion of the major salivary glands of IgG4-RS patients were accompanied by involvement of the lacrimal glands and cervical lymph nodes. Elevated IgE, allergic history, eosinophil infiltration suggest allergic reactions as a potential pathogenesis of IgG4-RS. Severity of glandular fibrosis correlated with salivary function and serum levels of IgG4.

语种英语
所属项目编号81271161 ; 814707566
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000358195000001
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58752
Collection北京大学口腔医学院_口腔病理科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dept Oral Radiol, Beijing 100081, Peoples R China
4.Peking Univ, Sch & Hosp Stomatol, Dept Oral Med, Beijing 100081, Peoples R China
5.Capital Univ Med Sci, Affiliated Beijing Tong Ren Hosp, Dept Nucl Med, Beijing 100730, Peoples R China
6.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Li, Wei,Chen, Yan,Sun, Zhi-Peng,et al. Clinicopathological characteristics of immunoglobulin G4-related sialadenitis[J]. ARTHRITIS RESEARCH & THERAPY,2015,17.
APA Li, Wei.,Chen, Yan.,Sun, Zhi-Peng.,Cai, Zhi-Gang.,Li, Tong-Tong.,...&Yu, Guang-Yan.(2015).Clinicopathological characteristics of immunoglobulin G4-related sialadenitis.ARTHRITIS RESEARCH & THERAPY,17.
MLA Li, Wei,et al."Clinicopathological characteristics of immunoglobulin G4-related sialadenitis".ARTHRITIS RESEARCH & THERAPY 17(2015).
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