|Clinicopathological characteristics of immunoglobulin G4-related sialadenitis|
|Li, Wei1; Chen, Yan2; Sun, Zhi-Peng3; Cai, Zhi-Gang1; Li, Tong-Tong1; Zhang, Lei1; Huang, Min-Xian1; Hua, Hong4; Li, Mei5; Hong, Xia1; Su, Jia-Zeng1; Zhang, Zhu-Yan3; Liu, Yan-Ying6; He, Jing6; Li, Zhan-Guo6; Gao, Yan2; Yu, Guang-Yan1|
|刊名||ARTHRITIS RESEARCH & THERAPY|
|WOS标题词||Science & Technology|
|关键词[WOS]||CHRONIC SCLEROSING SIALADENITIS ; IGG4-RELATED SYSTEMIC-DISEASE ; AUTOIMMUNE PANCREATITIS ; MIKULICZS-DISEASE ; SJOGRENS-SYNDROME ; SERUM IGG4 ; CRITERIA ; INFILTRATION ; TUMOR|
Introduction: Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized fibro-inflammatory condition. Forty-two cases with immunoglobulin G4-related sialadenitis (IgG4-RS) confirmed by histopathological and immunohistochemical assessment were studied to clarify the clinicopathologic characteristics of the salivary glands involved in IgG4-RS, especially the relationship between the histopathologic features and function of salivary glands or serum levels of IgG4.
Methods: Clinical, serologic, imaging and histopathological data of these cases were analyzed. CT volumes of submandibular, parotid, and lacrimal glands were calculated. The saliva flow rate was measured. Scintigraphy with 99mTc-pertechnetate was undertaken in 31 cases, and the concentration index (CI) and secretion index (SI) was calculated. Relationships between fibrosis severity and salivary gland function or serum IgG4 levels were analyzed.
Results: The first symptom was swelling of bilateral submandibular or lacrimal glands. Physical examination showed multiple bilateral major salivary glands (including sublingual and accessory parotid glands) and lacrimal glands were enlarged in IgG4 RS. Multiple enlarged cervical lymph nodes were noted in 30 patients. Saliva flow at rest was lower than normal in 34 cases; stimulated saliva flow was lower than normal in 15 cases. Secretory function was reduced more severely in the submandibular glands than in the parotid glands. Serum levels of IgG4 were elevated in 95.2% of cases and 78.6% patients had increased IgE levels. Serum IgG4 level was higher and saliva secretion lower as glandular fibrosis increased.
Conclusions: Prominent changes in the morphology, histology, immunohistochemistry and secretion of the major salivary glands of IgG4-RS patients were accompanied by involvement of the lacrimal glands and cervical lymph nodes. Elevated IgE, allergic history, eosinophil infiltration suggest allergic reactions as a potential pathogenesis of IgG4-RS. Severity of glandular fibrosis correlated with salivary function and serum levels of IgG4.
|项目编号||81271161 ; 814707566|
|资助机构||National Natural Science Foundation of China|
|作者单位||1.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China|
2.Peking Univ, Sch & Hosp Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dept Oral Radiol, Beijing 100081, Peoples R China
4.Peking Univ, Sch & Hosp Stomatol, Dept Oral Med, Beijing 100081, Peoples R China
5.Capital Univ Med Sci, Affiliated Beijing Tong Ren Hosp, Dept Nucl Med, Beijing 100730, Peoples R China
6.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
|Li, Wei,Chen, Yan,Sun, Zhi-Peng,et al. Clinicopathological characteristics of immunoglobulin G4-related sialadenitis[J]. ARTHRITIS RESEARCH & THERAPY,2015,17.|
|APA||Li, Wei.,Chen, Yan.,Sun, Zhi-Peng.,Cai, Zhi-Gang.,Li, Tong-Tong.,...&Yu, Guang-Yan.(2015).Clinicopathological characteristics of immunoglobulin G4-related sialadenitis.ARTHRITIS RESEARCH & THERAPY,17.|
|MLA||Li, Wei,et al."Clinicopathological characteristics of immunoglobulin G4-related sialadenitis".ARTHRITIS RESEARCH & THERAPY 17(2015).|