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Preoperative chemotherapy with a trastuzumab-containing regimen for a patient with gastric cancer and hepatic metastases
Li, Z. -Y.; Shan, F.; Zhang, L. -H.; Bu, Z. -D.; Wu, A. -W.; Wu, X. -J.; Zong, X. -L.; Li, S. -X.; Ji, X.; Ji, J. -F.
关键词Trastuzumab Gastric adenocarcinoma HER2 Liver metastasis Distal gastrectomy
刊名GENETICS AND MOLECULAR RESEARCH
2014
DOI10.4238/2014.December.19.17
13期:4页:10952-10957
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
资助者Major Cultivation Project of Beijing Medical Products and Technology ; Major Cultivation Project of Beijing Medical Products and Technology
研究领域[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
关键词[WOS]LIVER METASTASIS ; OXALIPLATIN ; RESECTION ; S-1
英文摘要

Gastric cancer is the fourth most common cancer worldwide and the leading cause of tumor-related death in China. Gastric cancer is a heterogeneous disease and therefore requires different treatments based on the subtype. We describe a patient who had gastric cancer with liver metastases. Biopsy and tumor analysis using the HercepTest revealed a human epidermal growth factor receptor 2 (HER2)-positive adenocarcinoma as confirmed by fluorescence in situ hybridization. The patient was treated with a regimen of trastuzumab, oxaliplatin, and S-1 (six cycles). When positron emission tomography findings suggested that the metastases had resolved, the patient underwent surgery. Histopathologically, no cancer cells were observed in the resected hepatic tissue. The patient underwent tumor resection surgery, during which the tumor and gastric lymph nodes with lesions were removed. The patient has remained disease-free for 3 months. Therefore, trastuzumab may be an effective agent in the chemotherapeutic treatment of liver metastases in patients with HER2-positive gastric adenocarcinoma.

语种英语
所属项目编号Z101107050210027
资助者Major Cultivation Project of Beijing Medical Products and Technology ; Major Cultivation Project of Beijing Medical Products and Technology
WOS记录号WOS:000350229200132
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58755
专题北京大学临床肿瘤学院
作者单位Peking Univ, Sch Oncol, Dept Surg, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Li, Z. -Y.,Shan, F.,Zhang, L. -H.,et al. Preoperative chemotherapy with a trastuzumab-containing regimen for a patient with gastric cancer and hepatic metastases[J]. GENETICS AND MOLECULAR RESEARCH,2014,13(4):10952-10957.
APA Li, Z. -Y..,Shan, F..,Zhang, L. -H..,Bu, Z. -D..,Wu, A. -W..,...&Ji, J. -F..(2014).Preoperative chemotherapy with a trastuzumab-containing regimen for a patient with gastric cancer and hepatic metastases.GENETICS AND MOLECULAR RESEARCH,13(4),10952-10957.
MLA Li, Z. -Y.,et al."Preoperative chemotherapy with a trastuzumab-containing regimen for a patient with gastric cancer and hepatic metastases".GENETICS AND MOLECULAR RESEARCH 13.4(2014):10952-10957.
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