IR@PKUHSC  > 北京大学第二临床医学院  > 心血管内科
学科主题临床医学
Carotid remodeling of hypertensive subjects and polymorphism of the angiotensin-converting enzyme gene
Li, SJ; Sun, NL; Zhou, SM
关键词hypertension carotid arteries remodeling angiotensin converting enzyme gene polymorphism
刊名CHINESE MEDICAL JOURNAL
2004
117期:1页:49-53
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]PLASMA ACE LEVELS ; INSERTION/DELETION POLYMORPHISM ; METABOLIC SYNDROME ; STIFFNESS ; ASSOCIATION ; STENOSIS ; SYSTEM
英文摘要

Background This study was designed to investigate the relationships between changes in the structure and function of carotid arteries and angiotensin converting enzyme (ACE) gene polymorphism in Chinese hypertensive subjects.

Methods Multiplex polymerase chain reaction amplification was used to evaluate the ACE gene insertion/deletion (I/D) polymorphism. High-resolution B-mode ultrasound examinations were performed to detect parameters of carotid artery remodeling.

Results Intima-media thickness (IMT) was significantly different among the DD, ID and II genotypes of ACE (DD > ID > II, P < 0.05). Carotid internal diameter, distensibility and stiffness were similar among the DD, ID and II genotypes of ACE (P > 0.05) in hypertensive subjects. The frequency of the DID gene and D allele of ACE were higher in patients with thickening carotid than in patients with normal carotid (70.4% vs 24.1%, and 79.5% vs 40.5%, respectively, P < 0.001). In multiple stepwise regression analysis, independent risk factors for increased carotid IMT in hypertensive subjects were ACE genotypes (P < 0.001), age (P < 0.001) and carotid internal diameter (P = 0.032). Moreover, triglycerides and total cholesterol were higher in patients with the DID genotype than in those with the I I genotype (P < 0.05).

Conclusions The I/D polymorphism of the ACE gene was related to IMT, but not to internal diameter, distensibility and stiffness of the carotid in Chinese hypertensive subjects. ACE gene polymorphism was a main risk factor for increased carotid IMT. These results may imply that there is a link between lipid metabolism and ACE genotype polymorphism in Chinese hypertensive subjects.

语种英语
WOS记录号WOS:000189012400010
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58756
专题北京大学第二临床医学院_心血管内科
作者单位1.Peking Univ, Dept Cardiol, Peoples Hosp, Beijing 100083, Peoples R China
2.Dalian Med Univ, Affiliated Hosp 4, Dept Cardiol, Dalian 116001, Peoples R China
推荐引用方式
GB/T 7714
Li, SJ,Sun, NL,Zhou, SM. Carotid remodeling of hypertensive subjects and polymorphism of the angiotensin-converting enzyme gene[J]. CHINESE MEDICAL JOURNAL,2004,117(1):49-53.
APA Li, SJ,Sun, NL,&Zhou, SM.(2004).Carotid remodeling of hypertensive subjects and polymorphism of the angiotensin-converting enzyme gene.CHINESE MEDICAL JOURNAL,117(1),49-53.
MLA Li, SJ,et al."Carotid remodeling of hypertensive subjects and polymorphism of the angiotensin-converting enzyme gene".CHINESE MEDICAL JOURNAL 117.1(2004):49-53.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, SJ]的文章
[Sun, NL]的文章
[Zhou, SM]的文章
百度学术
百度学术中相似的文章
[Li, SJ]的文章
[Sun, NL]的文章
[Zhou, SM]的文章
必应学术
必应学术中相似的文章
[Li, SJ]的文章
[Sun, NL]的文章
[Zhou, SM]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。