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学科主题: 临床医学
题名:
Carotid remodeling of hypertensive subjects and polymorphism of the angiotensin-converting enzyme gene
作者: Li, SJ; Sun, NL; Zhou, SM
关键词: hypertension ; carotid arteries ; remodeling ; angiotensin converting enzyme ; gene polymorphism
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2004
卷: 117, 期:1, 页:49-53
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: PLASMA ACE LEVELS ; INSERTION/DELETION POLYMORPHISM ; METABOLIC SYNDROME ; STIFFNESS ; ASSOCIATION ; STENOSIS ; SYSTEM
英文摘要:

Background This study was designed to investigate the relationships between changes in the structure and function of carotid arteries and angiotensin converting enzyme (ACE) gene polymorphism in Chinese hypertensive subjects.

Methods Multiplex polymerase chain reaction amplification was used to evaluate the ACE gene insertion/deletion (I/D) polymorphism. High-resolution B-mode ultrasound examinations were performed to detect parameters of carotid artery remodeling.

Results Intima-media thickness (IMT) was significantly different among the DD, ID and II genotypes of ACE (DD > ID > II, P < 0.05). Carotid internal diameter, distensibility and stiffness were similar among the DD, ID and II genotypes of ACE (P > 0.05) in hypertensive subjects. The frequency of the DID gene and D allele of ACE were higher in patients with thickening carotid than in patients with normal carotid (70.4% vs 24.1%, and 79.5% vs 40.5%, respectively, P < 0.001). In multiple stepwise regression analysis, independent risk factors for increased carotid IMT in hypertensive subjects were ACE genotypes (P < 0.001), age (P < 0.001) and carotid internal diameter (P = 0.032). Moreover, triglycerides and total cholesterol were higher in patients with the DID genotype than in those with the I I genotype (P < 0.05).

Conclusions The I/D polymorphism of the ACE gene was related to IMT, but not to internal diameter, distensibility and stiffness of the carotid in Chinese hypertensive subjects. ACE gene polymorphism was a main risk factor for increased carotid IMT. These results may imply that there is a link between lipid metabolism and ACE genotype polymorphism in Chinese hypertensive subjects.

语种: 英语
WOS记录号: WOS:000189012400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58756
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Dept Cardiol, Peoples Hosp, Beijing 100083, Peoples R China
2.Dalian Med Univ, Affiliated Hosp 4, Dept Cardiol, Dalian 116001, Peoples R China

Recommended Citation:
Li, SJ,Sun, NL,Zhou, SM. Carotid remodeling of hypertensive subjects and polymorphism of the angiotensin-converting enzyme gene[J]. CHINESE MEDICAL JOURNAL,2004,117(1):49-53.
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