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学科主题: 基础医学
题名:
Immunopotentiating effect of a ′Yang′-promoting formula of traditional Chinese medicine on aged female BALB/c mice
作者: Zhang, L; Wang, Y; Wang, LZ; Gao, XM
关键词: &prime ; Yang&prime ; -promoting ; traditional Chinese medicine ; immunity ; thymic involution
刊名: PHYTOTHERAPY RESEARCH
发表日期: 2004-10-01
DOI: 10.1002/ptr.1551
卷: 18, 期:10, 页:857-861
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: CRUDE DRUGS ; RADIX ; COMPONENTS ; EXPRESSION ; EXTRACT ; CELLS ; RATS
英文摘要:

The ′Yang′-promoting traditional Chinese medicines (TCM) are used to boost vigor and enhance immunity in humans. In this study, the immunopotentiating effect of VI-28, a ′Yang′-promoting TCM formula containing extracts of radix ginseng, cornu Cervi pantotrichum and radix Salvia miltiorrhizae, was investigated. Groups of 8-month-old female ex-breeder BALB/c mice were fed on ordinary mouse food or food containing a low (0.5%) or high (2%) dose VI-28 for up to 18 weeks. From week 6, mice on the TCM-containing diet were much healthier, stronger and more alert than those on the normal mouse food. Furthermore, their thymuses were significantly bigger and heavier than those of the control mice. Histological examination revealed structural changes typical of thymic involution in mice of the control group, whilst the microstructure of thymuses from mice taking TCM-containing food was comparable to that of mice of a much younger age, indicating a positive effect of VI-28 on slowing down thymic involution. Functional analysis of splenocytes from mice of different groups suggested that oral administration of VI-28 corrected the hyporesponsiveness of T lymphocytes in aged mice. These results have important implications for our understanding of the mechanisms of the immunoboosting effect of TCM. Copyright (C) 2004 John Wiley Sons, Ltd.

语种: 英语
WOS记录号: WOS:000225455900016
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58758
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Ctr Hlth Sci, Dept Immunol, Beijing 100083, Peoples R China
2.Chengdu Univ Tradit Chinese Med, Dept Immunol & Microbiol, Chengdu, Peoples R China

Recommended Citation:
Zhang, L,Wang, Y,Wang, LZ,et al. Immunopotentiating effect of a ′Yang′-promoting formula of traditional Chinese medicine on aged female BALB/c mice[J]. PHYTOTHERAPY RESEARCH,2004,18(10):857-861.
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