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学科主题: 公共卫生
题名:
Meta-Analysis of Dietary Glycemic Load and Glycemic Index in Relation to Risk of Coronary Heart Disease
作者: Dong, Jia-Yi1; Zhang, Yong-Hong2; Wang, Peiyu3; Qin, Li-Qiang1
刊名: AMERICAN JOURNAL OF CARDIOLOGY
发表日期: 2012-06-01
DOI: 10.1016/j.amjcard.2012.01.385
卷: 109, 期:11, 页:1608-1613
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: OBESE YOUNG-ADULTS ; CARDIOVASCULAR-DISEASE ; RANDOMIZED-TRIAL ; LIPID PROFILE ; BODY-WEIGHT ; WOMEN ; FAT ; CARBOHYDRATE ; OVERWEIGHT ; GLUCOSE
英文摘要:

A high glycemic diet may increase cardiovascular risk, yet whether the risk differs by gender or adiposity is inconclusive. Our goal was to determine the associations between dietary glycemic load (GL) and glycemic index (GI), and coronary heart disease (CHD) risk by conducting a meta-analysis of prospective studies. We searched the PubMed and Embase databases in July 2011 to identify eligible studies. The random-effects model was used to calculate pooled relative risks (RRs) comparing the highest categories of exposure to the lowest. Prespecified subgroup analyses were performed by gender and body mass index. We identified 8 prospective studies for meta-analysis, consisting of 220,050 participants and 4,826 incident CHD cases. Pooled RRs of CHD in relation to dietary GL were 1.08 (95% confidence interval [CI] 0.92 to 1.27) for men, 1.69 (95% CI 1.32 to 2.16) for women, and 1.36 (95% CI 1.13 to 1.63) for men and women combined. For dietary GI, corresponding pooled RRs were 0.99 (95% CI 0.84 to 1.16), 1.26 (95% CI 1.12 to 1.43), and 1.13 (95% CI 1.00 to 1.28), respectively. Limited evidence suggested the associations appeared more evident in the overweight and obese. There was no indication of publication bias. In conclusion, high dietary GL and GI significantly increased the risk of CHD in women but not in men, and the unfavorable effects may be more pronounced in overweight and obese patients. Further studies are needed to verify these findings and elucidate the underlying mechanisms. (C) 2012 Elsevier Inc. All rights reserved. (Am J Cardiol 2012; 109:1608-1613)

语种: 英语
WOS记录号: WOS:000304737800011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58762
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Soochow Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Suzhou, Peoples R China
2.Soochow Univ, Sch Publ Hlth, Dept Epidemiol, Suzhou, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing 100871, Peoples R China

Recommended Citation:
Dong, Jia-Yi,Zhang, Yong-Hong,Wang, Peiyu,et al. Meta-Analysis of Dietary Glycemic Load and Glycemic Index in Relation to Risk of Coronary Heart Disease[J]. AMERICAN JOURNAL OF CARDIOLOGY,2012,109(11):1608-1613.
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