北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Application of a nanotechnology antimicrobial spray to prevent lower urinary tract infection: a multicenter urology trial
作者: He, Wei3; Wang, Dongmin4; Ye, Zhangqun3; Qian, Weihong5; Tao, Yan5; Shi, Xiaofeng5; Liu, Ling6; Chen, Jin7; Qiu, Ling8; Wan, Peng9; Jia, Xiaojun10; Li, Xia11; Gao, Caixia12; Ma, Xuexia13; Wen, Biyan11; Chen, Nianzhen14; Li, Ping15; Ren, Zhengzheng16; Lan, Li17; Li, Siyi18; Zuo, Yi19; Zhang, Hua20; Ma, Liming20; Zhang, Yueping20; Li, Zhicong21; Su, Weiping22; Yang, Qing23; Chen, Qingli24; Wang, Xuejing24; Ye, Zhenni25; Chen, J. P.1; Loo, Wings T. Y.1,2; Chow, Louis W. C.2; Yip, Adrian Y. S.2; Ng, Elizabeth L. Y.2; Cheung, Mary N. B.2; Wang, Zhiping4
刊名: JOURNAL OF TRANSLATIONAL MEDICINE
发表日期: 2012-09-19
DOI: 10.1186/1479-5876-10-S1-S14
卷: suppl.1
收录类别: SCI ; ISTP
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: CATHETER-ASSOCIATED UROPATHOGENS ; BIOFILM FORMATION ; INDWELLING CATHETER ; BACTERIAL BIOFILMS ; ESCHERICHIA-COLI ; CLINICAL-TRIAL ; IN-VITRO ; CARE ; PATHOGENESIS ; MATRIX
英文摘要:

Background: Catheter-associated urinary tract infection (CAUTI) is a common nosocomial device-associated infection. It is now recognized that the high infection rates were caused by the formation of biofilm on the surface of the catheters that decreases the susceptibility to antibiotics and results in anti-microbial resistance.

In this study, we performed an in vitro test to explore the mechanism of biofilm formation and subsequently conducted a multi-center clinical trial to investigate the efficacy of CAUTI prevention with the application of JUC, a nanotechnology antimicrobial spray.

Methods: Siliconized latex urinary catheters were cut into fragments and sterilized by autoclaving. The sterilized sample fragments were randomly divided into the therapy and control group, whereby they were sprayed with JUC and distilled water respectively and dried before use.

The experimental standard strains of Escherichia coli (E. coli) were isolated from the urine samples of patients. At 16 hours and 7 days of incubation, the samples were extracted for confocal laser scanning microscopy. A total of 1,150 patients were accrued in the clinical study. Patients were randomized according to the order of surgical treatment. The odd array of patients was assigned as the therapy group (JUC), and the even array of patients was assigned as the control group (normal saline).

Results: After 16 hours of culture, bacterial biofilm formed on the surface of sample fragments from the control group. In the therapy group, no bacterial biofilm formation was observed on the sample fragments. No significant increase in bacterial colony count was observed in the therapy group after 7 days of incubation.

On the 7th day of catheterization, urine samples were collected for bacterial culture before extubation. Significant difference was observed in the incidence of bacteriuria between the therapy group and control group (4.52% vs. 13.04%, p < 0.001).

Conclusions: In this study, the effectiveness of JUC in preventing CAUTI in a hospital setting was demonstrated in both in vitro and clinical studies.

语种: 英语
WOS记录号: WOS:000309359300014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58764
Appears in Collections:北京大学第二临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Sichuan Univ, W China Hosp, Chengdu, Sichuan, Peoples R China
2.UNIMED Med Inst, Hong Kong, Hong Kong, Peoples R China
3.Wuhan Gen Hosp Guangzhou Mil Reg, Guangzhou, Guangdong, Peoples R China
4.Univ Hong Kong, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China
5.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp Affiliated, Dept Urol, Wuhan, Hubei, Peoples R China
6.Lanzhou Univ, Hosp 2, Inst Urol, Lanzhou 730000, Peoples R China
7.Third Mil Med Univ, Daping Hosp, Chongqing, Peoples R China
8.Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China
9.Second Mil Med Univ, Changhai Hosp, Shanghai, Peoples R China
10.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
11.Sun Yat Sen Univ, Affiliated Hosp 3, Guangzhou, Guangdong, Peoples R China
12.Xi An Jiao Tong Univ, Second Hosp, Xian 710049, Peoples R China
13.Sun Yat Sen Univ, Affiliated Hosp 2, Guangzhou 510275, Guangdong, Peoples R China
14.Cent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
15.Nanjing Univ, Sch Med, Affiliated Hosp, Nanjing Drum Tower Hosp, Nanjing, Jiangsu, Peoples R China
16.Nanjing Med Univ, Huaian Hosp Affiliated 1, Nanjing, Jiangsu, Peoples R China
17.Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou 510275, Guangdong, Peoples R China
18.Guangzhou Univ Tradit Chinese Med, Affiliated Hosp 2, Guangzhou, Guangdong, Peoples R China
19.So Med Univ, Affiliated Hosp 1, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
20.Nantong Univ, Affiliated Hosp, Nantong, Jiangsu, Peoples R China
21.Foshan Hosp Tradit Chinese Med, Guangzhou, Guangdong, Peoples R China
22.Guangzhou First Municipal Peoples Hosp, Guangzhou, Guangdong, Peoples R China
23.Gen Hosp Guangzhou Mil Command PLA, Guangzhou, Guangdong, Peoples R China
24.Nanjing Med Univ, Affiliated Hosp 1, Nanjing, Jiangsu, Peoples R China
25.Kunming Med Coll, Affiliated Hosp 2, Kunming, Yunnan, Peoples R China

Recommended Citation:
He, Wei,Wang, Dongmin,Ye, Zhangqun,et al. Application of a nanotechnology antimicrobial spray to prevent lower urinary tract infection: a multicenter urology trial[J]. JOURNAL OF TRANSLATIONAL MEDICINE,2012,suppl.1.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[He, Wei]'s Articles
[Wang, Dongmin]'s Articles
[Ye, Zhangqun]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[He, Wei]‘s Articles
[Wang, Dongmin]‘s Articles
[Ye, Zhangqun]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace