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学科主题: 临床医学
题名:
Haploidentical Bone Marrow Transplantation Without T-Cell Depletion
作者: Chang, Ying-Jun; Huang, Xiao-Jun
刊名: SEMINARS IN ONCOLOGY
发表日期: 2012-12-01
DOI: 10.1053/j.seminoncol.2012.09.003
卷: 39, 期:6, 页:653-663
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HLA-MISMATCHED/HAPLOIDENTICAL BLOOD ; UMBILICAL-CORD BLOOD ; IDENTICAL SIBLING TRANSPLANTATION ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; DONOR LYMPHOCYTE INFUSION ; MESENCHYMAL STEM-CELLS ; NATURAL-KILLER-CELLS ; VERSUS-HOST-DISEASE ; HEMATOLOGIC MALIGNANCIES ; HIGH-RISK
英文摘要:

Approaches for haploidentical bone marrow transplantation (BMT) without T-cell depletion have been designed using new transplant strategies, including anti-thymocyte globulin (ATG) preparative regimens, granulocyte colony-stimulating factor-primed grafts, post-transplantation rapamycin, or high-dose cyclophosphamide (Cy) in combination with other immunosuppressive agents for graft-versus-host disease (GVHD) prophylaxis. These strategies ensured fast hematologic engraftment across the human leukocyte antigen (HLA) barrier with an acceptable incidence of GVHD. Long-term follow-up results from different transplant centers suggest that unmanipulated transplantation may provide an alternative strategy in the haploidentical setting without requiring the technical expertise and cost of ex vivo T-cell depletion. This review discusses immune reconstitution and factors associated with clinical outcomes following unmanipulated haploidentical hematopoietic stem cell transplantation (HSCT), and compares outcomes between unmanipulated haploidentical transplant versus HLA-matched sibling donor (MSD) transplantation, HLA-matched unrelated donor (MUD). transplantation, or unrelated double umbilical cord blood (dUCB) transplantation. Advantages and disadvantages of unmanipulated haploidentical HSCT and strategies to improve outome after haploidentical BMT without ex vivo T-cell depletion are discussed. Semin Oncol 39:653-663 (C) 2012 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000312358600004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58767
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China

Recommended Citation:
Chang, Ying-Jun,Huang, Xiao-Jun. Haploidentical Bone Marrow Transplantation Without T-Cell Depletion[J]. SEMINARS IN ONCOLOGY,2012,39(6):653-663.
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