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学科主题临床医学
Haploidentical Bone Marrow Transplantation Without T-Cell Depletion
Chang, Ying-Jun; Huang, Xiao-Jun
刊名SEMINARS IN ONCOLOGY
2012-12-01
DOI10.1053/j.seminoncol.2012.09.003
39期:6页:653-663
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]HLA-MISMATCHED/HAPLOIDENTICAL BLOOD ; UMBILICAL-CORD BLOOD ; IDENTICAL SIBLING TRANSPLANTATION ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; DONOR LYMPHOCYTE INFUSION ; MESENCHYMAL STEM-CELLS ; NATURAL-KILLER-CELLS ; VERSUS-HOST-DISEASE ; HEMATOLOGIC MALIGNANCIES ; HIGH-RISK
英文摘要

Approaches for haploidentical bone marrow transplantation (BMT) without T-cell depletion have been designed using new transplant strategies, including anti-thymocyte globulin (ATG) preparative regimens, granulocyte colony-stimulating factor-primed grafts, post-transplantation rapamycin, or high-dose cyclophosphamide (Cy) in combination with other immunosuppressive agents for graft-versus-host disease (GVHD) prophylaxis. These strategies ensured fast hematologic engraftment across the human leukocyte antigen (HLA) barrier with an acceptable incidence of GVHD. Long-term follow-up results from different transplant centers suggest that unmanipulated transplantation may provide an alternative strategy in the haploidentical setting without requiring the technical expertise and cost of ex vivo T-cell depletion. This review discusses immune reconstitution and factors associated with clinical outcomes following unmanipulated haploidentical hematopoietic stem cell transplantation (HSCT), and compares outcomes between unmanipulated haploidentical transplant versus HLA-matched sibling donor (MSD) transplantation, HLA-matched unrelated donor (MUD). transplantation, or unrelated double umbilical cord blood (dUCB) transplantation. Advantages and disadvantages of unmanipulated haploidentical HSCT and strategies to improve outome after haploidentical BMT without ex vivo T-cell depletion are discussed. Semin Oncol 39:653-663 (C) 2012 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000312358600004
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58767
专题北京大学第二临床医学院_血液科
作者单位Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
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GB/T 7714
Chang, Ying-Jun,Huang, Xiao-Jun. Haploidentical Bone Marrow Transplantation Without T-Cell Depletion[J]. SEMINARS IN ONCOLOGY,2012,39(6):653-663.
APA Chang, Ying-Jun,&Huang, Xiao-Jun.(2012).Haploidentical Bone Marrow Transplantation Without T-Cell Depletion.SEMINARS IN ONCOLOGY,39(6),653-663.
MLA Chang, Ying-Jun,et al."Haploidentical Bone Marrow Transplantation Without T-Cell Depletion".SEMINARS IN ONCOLOGY 39.6(2012):653-663.
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