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学科主题临床医学
Biodegradable chitin conduit tubulation combined with bone marrow mesenchymal stem cell transplantation for treatment of spinal cord injury by reducing glial scar and cavity formation
Xue, Feng1; Wu, Er-jun2; Zhang, Pei-xun1; A, Li-ya1; Kou, Yu-hui1; Yin, Xiao-feng1; Han, Na3
关键词nerve regeneration spinal cord injury spinal cord hemisection biological conduit bone marrow mesenchymal stem cells stem cells transmission electron microscope cell transplantation neurons nerve fibers NSFC grants neural regeneration
刊名NEURAL REGENERATION RESEARCH
2015
DOI10.4103/1673-5374.150715
10期:1页:104-111
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Neurosciences
资助者National Program on Key Basic Research Project of China (973 Program) ; Program for Innovative Research Team in University of Ministry of Education of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University of Ministry of Education of China ; Natural Science Foundation of Beijing of China ; National Program on Key Basic Research Project of China (973 Program) ; Program for Innovative Research Team in University of Ministry of Education of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University of Ministry of Education of China ; Natural Science Foundation of Beijing of China
研究领域[WOS]Cell Biology ; Neurosciences & Neurology
关键词[WOS]MEDIAN NERVE INJURY ; SMALL-GAP ; STROMAL CELLS ; FUNCTIONAL RECOVERY ; LOCOMOTOR RECOVERY ; RATS ; REGENERATION ; SCAFFOLD ; SCHWANN
英文摘要

We examined the restorative effect of modified biodegradable chitin conduits in combination with bone marrow mesenchymal stem cell transplantation after right spinal cord hemisection injury. Immunohistochemical staining revealed that biological conduit sleeve bridging reduced glial scar formation and spinal muscular atrophy after spinal cord hemisection. Bone marrow mesenchymal stem cells survived and proliferated after transplantation in vivo, and differentiated into cells double-positive for S100 (Schwann cell marker) and glial fibrillary acidic protein (glial cell marker) at 8 weeks. Retrograde tracing showed that more nerve fibers had grown through the injured spinal cord at 14 weeks after combination therapy than either treatment alone. Our findings indicate that a biological conduit combined with bone marrow mesenchymal stem cell transplantation effectively prevented scar formation and provided a favorable local microenvironment for the proliferation, migration and differentiation of bone marrow mesenchymal stem cells in the spinal cord, thus promoting restoration following spinal cord hemisection injury.

语种英语
所属项目编号2014CB542201 ; IRT1201 ; 31271284 ; 31171150 ; 81171146 ; 30971526 ; 31100860 ; 31040043 ; BMU20110270 ; 7142164
资助者National Program on Key Basic Research Project of China (973 Program) ; Program for Innovative Research Team in University of Ministry of Education of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University of Ministry of Education of China ; Natural Science Foundation of Beijing of China ; National Program on Key Basic Research Project of China (973 Program) ; Program for Innovative Research Team in University of Ministry of Education of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University of Ministry of Education of China ; Natural Science Foundation of Beijing of China
WOS记录号WOS:000350098100026
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58778
专题北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Dept Trauma & Orthoped, Beijing 100871, Peoples R China
2.Shanxi Med Univ, Grad Sch, Taiyuan, Shanxi Province, Peoples R China
3.Peking Univ, Peoples Hosp, Cent Lab, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Xue, Feng,Wu, Er-jun,Zhang, Pei-xun,et al. Biodegradable chitin conduit tubulation combined with bone marrow mesenchymal stem cell transplantation for treatment of spinal cord injury by reducing glial scar and cavity formation[J]. NEURAL REGENERATION RESEARCH,2015,10(1):104-111.
APA Xue, Feng.,Wu, Er-jun.,Zhang, Pei-xun.,A, Li-ya.,Kou, Yu-hui.,...&Han, Na.(2015).Biodegradable chitin conduit tubulation combined with bone marrow mesenchymal stem cell transplantation for treatment of spinal cord injury by reducing glial scar and cavity formation.NEURAL REGENERATION RESEARCH,10(1),104-111.
MLA Xue, Feng,et al."Biodegradable chitin conduit tubulation combined with bone marrow mesenchymal stem cell transplantation for treatment of spinal cord injury by reducing glial scar and cavity formation".NEURAL REGENERATION RESEARCH 10.1(2015):104-111.
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