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学科主题: 临床医学
题名:
Biodegradable chitin conduit tubulation combined with bone marrow mesenchymal stem cell transplantation for treatment of spinal cord injury by reducing glial scar and cavity formation
作者: Xue, Feng1; Wu, Er-jun2; Zhang, Pei-xun1; A, Li-ya1; Kou, Yu-hui1; Yin, Xiao-feng1; Han, Na3
关键词: nerve regeneration ; spinal cord injury ; spinal cord hemisection ; biological conduit ; bone marrow mesenchymal stem cells ; stem cells ; transmission electron microscope ; cell transplantation ; neurons ; nerve fibers ; NSFC grants ; neural regeneration
刊名: NEURAL REGENERATION RESEARCH
发表日期: 2015
DOI: 10.4103/1673-5374.150715
卷: 10, 期:1, 页:104-111
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Neurosciences
研究领域[WOS]: Cell Biology ; Neurosciences & Neurology
关键词[WOS]: MEDIAN NERVE INJURY ; SMALL-GAP ; STROMAL CELLS ; FUNCTIONAL RECOVERY ; LOCOMOTOR RECOVERY ; RATS ; REGENERATION ; SCAFFOLD ; SCHWANN
英文摘要:

We examined the restorative effect of modified biodegradable chitin conduits in combination with bone marrow mesenchymal stem cell transplantation after right spinal cord hemisection injury. Immunohistochemical staining revealed that biological conduit sleeve bridging reduced glial scar formation and spinal muscular atrophy after spinal cord hemisection. Bone marrow mesenchymal stem cells survived and proliferated after transplantation in vivo, and differentiated into cells double-positive for S100 (Schwann cell marker) and glial fibrillary acidic protein (glial cell marker) at 8 weeks. Retrograde tracing showed that more nerve fibers had grown through the injured spinal cord at 14 weeks after combination therapy than either treatment alone. Our findings indicate that a biological conduit combined with bone marrow mesenchymal stem cell transplantation effectively prevented scar formation and provided a favorable local microenvironment for the proliferation, migration and differentiation of bone marrow mesenchymal stem cells in the spinal cord, thus promoting restoration following spinal cord hemisection injury.

语种: 英语
所属项目编号: 2014CB542201 ; IRT1201 ; 31271284 ; 31171150 ; 81171146 ; 30971526 ; 31100860 ; 31040043 ; BMU20110270 ; 7142164
项目资助者: National Program on Key Basic Research Project of China (973 Program) ; Program for Innovative Research Team in University of Ministry of Education of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University of Ministry of Education of China ; Natural Science Foundation of Beijing of China
WOS记录号: WOS:000350098100026
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58778
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Trauma & Orthoped, Beijing 100871, Peoples R China
2.Shanxi Med Univ, Grad Sch, Taiyuan, Shanxi Province, Peoples R China
3.Peking Univ, Peoples Hosp, Cent Lab, Beijing 100871, Peoples R China

Recommended Citation:
Xue, Feng,Wu, Er-jun,Zhang, Pei-xun,et al. Biodegradable chitin conduit tubulation combined with bone marrow mesenchymal stem cell transplantation for treatment of spinal cord injury by reducing glial scar and cavity formation[J]. NEURAL REGENERATION RESEARCH,2015,10(1):104-111.
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