IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Intradermal microbubbles and contrast-enhanced ultrasound (CEUS) is a feasible approach for sentinel lymph node identification in early-stage breast cancer
Xie, Fei1; Zhang, Dongjie1; Cheng, Lin1; Yu, Lei2; Yang, Li2; Tong, Fuzhong1; Liu, Hongjun1; Wang, Shu2; Wang, Shan3
关键词Sentinel lymph node (SLN) Sentinel lymph node biopsy (SLNB) Microbubbles Contrast-enhanced ultrasonography (CEUS) Blue dye SonoVue Breast cancer
刊名WORLD JOURNAL OF SURGICAL ONCOLOGY
2015-11-19
DOI10.1186/s12957-015-0736-x
13
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Surgery
资助者Foundation for Scientific Research and Development of Peking University People&prime ; s Hospital ; Foundation for Scientific Research and Development of Peking University People&prime ; s Hospital
研究领域[WOS]Oncology ; Surgery
关键词[WOS]INDOCYANINE GREEN FLUORESCENCE ; AXILLARY DISSECTION ; CLINICAL-TRIAL ; SWINE MODEL ; BLUE-DYE ; BIOPSY ; LYMPHADENECTOMY ; INVOLVEMENT ; SYSTEM ; LOCALIZATION
英文摘要

Background: Microbubbles and contrast-enhanced ultrasound (CEUS) is a new technique for locating sentinel lymph node (SLN). The aim of this study is to explore the feasibility of SLNs tracing by CEUS using microbubbles in breast cancer patients and the value of enhancing patterns in diagnosing lymph nodes metastases.

Methods: A clinical trial was registered (trial registration: ChiCTR-DDT-13003778). One hundred and one consecutive consenting patients with breast cancer undergoing SLN biopsy were enrolled. Before the surgery, microbubble was injected periareolarly. Lymphatic drainage pathway was detected by CEUS, and guidewire was deployed to locate the SLN before the operation. Blue dye was also used to help in tracing sentinel lymph node during the operation. The identification rate and the accuracy rate were recorded. Enhancing patterns of lymph nodes were recorded and compared with the pathological diagnosis.

Results: Of the 101 cases, SLNs in 99 cases were successfully identified by at least one tracer, including 98 cases identified by CEUS and 97 cases by blue dye. There was no significant difference between the two methods (P = 0.705). Guidewires were deployed successfully in all 98 cases, and the localized SLNs were all isolated successfully in the following operations. The status of SLNs isolated by CEUS was completely identical to that of the whole axillary lymph node while 7.1 % cases were misdiagnosed as negative by blue dye method. The sensitivity of predicting SLNs metastases by CEUS enhancing pattern was 81.8 %, the specificity was 86.2 %, and the positive and negative predictive values were 75.0 and 90.3 %, respectively.

Conclusions: Microbubbles and CEUS are feasible approaches for SLN identification. The enhancing patterns on CEUS may be helpful to recognize the metastasizing SLNs. This novel method may be a promising technique for the clinical application.

语种英语
所属项目编号RDC2012-13
资助者Foundation for Scientific Research and Development of Peking University People&prime ; s Hospital ; Foundation for Scientific Research and Development of Peking University People&prime ; s Hospital
WOS记录号WOS:000365266500001
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58780
专题北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Dept Breast Dis, Beijing 100871, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Ultrasound Diag, Beijing 100871, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Gastrointestinal Surg, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Xie, Fei,Zhang, Dongjie,Cheng, Lin,et al. Intradermal microbubbles and contrast-enhanced ultrasound (CEUS) is a feasible approach for sentinel lymph node identification in early-stage breast cancer[J]. WORLD JOURNAL OF SURGICAL ONCOLOGY,2015,13.
APA Xie, Fei.,Zhang, Dongjie.,Cheng, Lin.,Yu, Lei.,Yang, Li.,...&Wang, Shan.(2015).Intradermal microbubbles and contrast-enhanced ultrasound (CEUS) is a feasible approach for sentinel lymph node identification in early-stage breast cancer.WORLD JOURNAL OF SURGICAL ONCOLOGY,13.
MLA Xie, Fei,et al."Intradermal microbubbles and contrast-enhanced ultrasound (CEUS) is a feasible approach for sentinel lymph node identification in early-stage breast cancer".WORLD JOURNAL OF SURGICAL ONCOLOGY 13(2015).
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