北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 血液科  > 期刊论文
学科主题: 临床医学
题名:
Different kinetic patterns of BCR-ABL transcript levels in imatinib-treated chronic myeloid leukemia patients after achieving complete cytogenetic response
作者: Qin, Y. Z.; Liu, Y. R.; Zhu, H. H.; Li, J. L.; Ruan, G. R.; Zhang, Y.; Jiang, Q.; Jiang, H.; Li, L. D.; Chang, Y.; Huang, X. J.; Chen, S. S.
关键词: chronic myeloid leukemia ; BCR-ABL ; imatinib ; real-time quantitative PCR
刊名: INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
发表日期: 2008-08-01
DOI: 10.1111/j.1751-553X.2007.00962.x
卷: 30, 期:4, 页:317-323
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: CHRONIC MYELOGENOUS LEUKEMIA ; RESIDUAL DISEASE DETECTION ; POLYMERASE-CHAIN-REACTION ; ALPHA PLUS CYTARABINE ; INTERFERON-ALPHA ; CHRONIC PHASE ; MOLECULAR RESPONSES ; PHILADELPHIA-CHROMOSOME ; CANCER PROGRAM ; CML
英文摘要:

Bone marrow BCR-ABL transcript levels were monitored serially by real-time quantitative PCR in 46 imatinib-treated chronic myeloid leukemia patients after achieving complete cytogenetic response (CCyR) for a median of 42 months (range: 9-53). Of 41 patients in continuous CCyR, 32 and nine could achieve a >= 3-log (MMoR group) or 2- to 3-log reduction (non-MMoR group), respectively. The MMoR group had a significantly lower recurrence rate of Ph+ metaphase than the non-MMoR group (6/32 vs. 7/9, P = 0.002), which was not significantly different between patients first achieving CCyR within or after 12 months of imatinib treatment (7/27 vs. 6/14, P = 0.086). Five patients suffered cytogenetic or hematological relapse. For all 46 patients, a > 2-log reduction but not time when CCyR was first achieved was related to a lower relapse rate (1/42 vs. 4/4, P < 0.001). We concluded that the depth of BCR-ABL reduction after CCyR is more critical than when CCyR is first achieved. The kinetic pattern of BCR-ABL transcript is a good predictor of disease stability.

语种: 英语
WOS记录号: WOS:000257716900009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58781
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Peoples Hosp, Inst Hematol, Beijing, Peoples R China

Recommended Citation:
Qin, Y. Z.,Liu, Y. R.,Zhu, H. H.,et al. Different kinetic patterns of BCR-ABL transcript levels in imatinib-treated chronic myeloid leukemia patients after achieving complete cytogenetic response[J]. INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY,2008,30(4):317-323.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Qin, Y. Z.]'s Articles
[Liu, Y. R.]'s Articles
[Zhu, H. H.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Qin, Y. Z.]‘s Articles
[Liu, Y. R.]‘s Articles
[Zhu, H. H.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace