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Different kinetic patterns of BCR-ABL transcript levels in imatinib-treated chronic myeloid leukemia patients after achieving complete cytogenetic response
Qin, Y. Z.; Liu, Y. R.; Zhu, H. H.; Li, J. L.; Ruan, G. R.; Zhang, Y.; Jiang, Q.; Jiang, H.; Li, L. D.; Chang, Y.; Huang, X. J.; Chen, S. S.
关键词chronic myeloid leukemia BCR-ABL imatinib real-time quantitative PCR
刊名INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
2008-08-01
DOI10.1111/j.1751-553X.2007.00962.x
30期:4页:317-323
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]CHRONIC MYELOGENOUS LEUKEMIA ; RESIDUAL DISEASE DETECTION ; POLYMERASE-CHAIN-REACTION ; ALPHA PLUS CYTARABINE ; INTERFERON-ALPHA ; CHRONIC PHASE ; MOLECULAR RESPONSES ; PHILADELPHIA-CHROMOSOME ; CANCER PROGRAM ; CML
英文摘要

Bone marrow BCR-ABL transcript levels were monitored serially by real-time quantitative PCR in 46 imatinib-treated chronic myeloid leukemia patients after achieving complete cytogenetic response (CCyR) for a median of 42 months (range: 9-53). Of 41 patients in continuous CCyR, 32 and nine could achieve a >= 3-log (MMoR group) or 2- to 3-log reduction (non-MMoR group), respectively. The MMoR group had a significantly lower recurrence rate of Ph+ metaphase than the non-MMoR group (6/32 vs. 7/9, P = 0.002), which was not significantly different between patients first achieving CCyR within or after 12 months of imatinib treatment (7/27 vs. 6/14, P = 0.086). Five patients suffered cytogenetic or hematological relapse. For all 46 patients, a > 2-log reduction but not time when CCyR was first achieved was related to a lower relapse rate (1/42 vs. 4/4, P < 0.001). We concluded that the depth of BCR-ABL reduction after CCyR is more critical than when CCyR is first achieved. The kinetic pattern of BCR-ABL transcript is a good predictor of disease stability.

语种英语
WOS记录号WOS:000257716900009
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58781
专题北京大学第二临床医学院_血液科
作者单位Peking Univ, Peoples Hosp, Inst Hematol, Beijing, Peoples R China
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GB/T 7714
Qin, Y. Z.,Liu, Y. R.,Zhu, H. H.,et al. Different kinetic patterns of BCR-ABL transcript levels in imatinib-treated chronic myeloid leukemia patients after achieving complete cytogenetic response[J]. INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY,2008,30(4):317-323.
APA Qin, Y. Z..,Liu, Y. R..,Zhu, H. H..,Li, J. L..,Ruan, G. R..,...&Chen, S. S..(2008).Different kinetic patterns of BCR-ABL transcript levels in imatinib-treated chronic myeloid leukemia patients after achieving complete cytogenetic response.INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY,30(4),317-323.
MLA Qin, Y. Z.,et al."Different kinetic patterns of BCR-ABL transcript levels in imatinib-treated chronic myeloid leukemia patients after achieving complete cytogenetic response".INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY 30.4(2008):317-323.
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