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Regulators of G protein signaling are up-regulated in aspirin-resistant platelets from patients with metabolic syndrome
Mao, Yuanjie1,2; Lei, Lei3; Su, Jialin1,4,5; Yu, Yang1; Liu, Zhaoping1; Huo, Yong1
刊名PHARMAZIE
2014-05-01
DOI10.1691/ph.2014.3833
69期:5页:371-373
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]CARDIOVASCULAR-DISEASE ; ACTIVATION
英文摘要

G protein-coupled receptor signaling plays a crucial role in platelet function. Regulators of G protein signaling (RGSs), which accelerate the deactivation of G protein signaling, are expressed in platelets. However, RGS expression has not been studied in the context of aspirin resistance. We compared RGS nnRNA levels in platelets from 39 aspirin-resistant patients and 50 aspirin-sensitive patients with metabolic syndrome. Although there were no clinical differences between the two groups, transcripts of RGS2, RGS10, and RGS18 were significantly higher in aspirin-resistant patients than in aspirin-sensitive patients. This study is the first to demonstrate that RGS transcripts are elevated in aspirin-resistant platelets from patients with metabolic syndrome.

语种英语
WOS记录号WOS:000335715300010
项目编号NSFC30600230
资助机构National Nature Science Foundation of China ; Chinese Doctoral Foundation
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58784
专题北京大学第一临床医学院_心血管内科
作者单位1.Beijing Aerosp Ctr Hosp, Dept Endocrinol, Beijing, Peoples R China
2.Rhode Isl Hosp, Div Cardiol, Cardiovasc Res Ctr, Providence, RI USA
3.Brown Univ, Alpert Med Sch, Providence, RI 02912 USA
4.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100034, Peoples R China
5.Natl Cerebral & Cardiovasc Ctr, Dept Biochem, Osaka, Japan
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GB/T 7714
Mao, Yuanjie,Lei, Lei,Su, Jialin,et al. Regulators of G protein signaling are up-regulated in aspirin-resistant platelets from patients with metabolic syndrome[J]. PHARMAZIE,2014,69(5):371-373.
APA Mao, Yuanjie,Lei, Lei,Su, Jialin,Yu, Yang,Liu, Zhaoping,&Huo, Yong.(2014).Regulators of G protein signaling are up-regulated in aspirin-resistant platelets from patients with metabolic syndrome.PHARMAZIE,69(5),371-373.
MLA Mao, Yuanjie,et al."Regulators of G protein signaling are up-regulated in aspirin-resistant platelets from patients with metabolic syndrome".PHARMAZIE 69.5(2014):371-373.
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