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学科主题: 药学
题名:
Efficient and Practical Oxidative Bromination and Iodination of Arenes and Heteroarenes with DMSO and Hydrogen Halide: A Mild Protocol for Late-Stage Functionalization
作者: Song, Song1; Sun, Xiang1; Li, Xinwei1; Yuan, Yizhi1; Jiao, Ning1,2
刊名: ORGANIC LETTERS
发表日期: 2015-06-19
DOI: 10.1021/acs.orglett.5b00932
卷: 17, 期:12, 页:2886-2889
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: C-H BONDS ; REGIOSELECTIVE HALOGENATION ; ALKOXYSULFONIUM IONS ; DIMETHYL-SULFOXIDE ; CATALYTIC METHOD ; FACILE SYNTHESIS ; METHYL KETONES ; STRATEGY ; ALKENES ; BROMIDE
英文摘要:

An efficient and practical system for inexpensive bromination and iodination of arenes as well as heteroarenes by using readily available dimethyl sulfoxide (DMSO) and HX (X = Br, I) reagents is reported. This mild oxidative system demonstrates a versatile protocol for the synthesis of aryl halides. HX (X = Br, I) are employed as halogenating reagents when combined with DMSO which participates in the present chemistry as a mild and inexpensive oxidant. This oxidative system is amenable to late-stage bromination of natural products. The kilogram-scale experiment (>95% yield) shows great potential for industrial application.

语种: 英语
所属项目编号: 2015CB856600 ; 21325206 ; 21172006
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Young Top-notch Talent Support Program
WOS记录号: WOS:000356845000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58785
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

Recommended Citation:
Song, Song,Sun, Xiang,Li, Xinwei,et al. Efficient and Practical Oxidative Bromination and Iodination of Arenes and Heteroarenes with DMSO and Hydrogen Halide: A Mild Protocol for Late-Stage Functionalization[J]. ORGANIC LETTERS,2015,17(12):2886-2889.
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