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CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia
Cui, Yajuan1,2; Li, Bing1,2; Gale, Robert Peter3; Jiang, Qian4; Xu, Zefeng1,2; Qin, Tiejun1,2; Zhang, Peihong2,5; Zhang, Yue1,2,6; Xiao, Zhijian1,2,6
关键词Chronic neutrophilic leukemia CNL CSF3R SETBP1 CALR Mutation
刊名JOURNAL OF HEMATOLOGY & ONCOLOGY
2014-10-15
DOI10.1186/s13045-014-0077-1
7
收录类别SCI
文章类型Letter
WOS标题词Science & Technology
类目[WOS]Oncology ; Hematology
研究领域[WOS]Oncology ; Hematology
关键词[WOS]STIMULATING FACTOR-RECEPTOR ; ATYPICAL CML ; T618I
英文摘要

The WHO 2008 definition of chronic neutrophilic leukemia (CNL) is based on clinical and laboratory parameters but not on molecular abnormalities. Mutations in CSF3R, SETBP1 and CALR are reported in patients with chronic neutrophilic leukemia (CNL). However, because CNL is rare, there are few large studies of this issue. We sequenced these genes in 14 patients who met the WHO-criteria of CNL. 8 subjects had CSF3R(T6181), 6 SETBP1 mutations and 1 a CALR mutation. Our data suggest mutation analysis of CSF3R, SETBP1 and CALR should be included in the diagnostic criteria for CNL. These data may also have therapy implications.

语种英语
WOS记录号WOS:000346310400001
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58791
专题北京大学第二临床医学院_血液科
作者单位1.Chinese Acad Med Sci, Inst Hematol & Blood Dis Hosp, MDS & MPN Ctr, Tianjin 300020, Peoples R China
2.Peking Union Med Coll, Tianjin 300020, Peoples R China
3.Univ London Imperial Coll Sci Technol & Med, Hematol Res Ctr, Dept Med, Div Expt Med, London, England
4.Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100871, Peoples R China
5.Chinese Acad Med Sci, Inst Hematol & Blood Dis Hosp, Dept Pathol, Tianjin 300020, Peoples R China
6.Chinese Acad Med Sci, Inst Hematol & Blood Dis Hosp, State Key Lab Expt Hematol, Tianjin 300020, Peoples R China
推荐引用方式
GB/T 7714
Cui, Yajuan,Li, Bing,Gale, Robert Peter,et al. CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia[J]. JOURNAL OF HEMATOLOGY & ONCOLOGY,2014,7.
APA Cui, Yajuan.,Li, Bing.,Gale, Robert Peter.,Jiang, Qian.,Xu, Zefeng.,...&Xiao, Zhijian.(2014).CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia.JOURNAL OF HEMATOLOGY & ONCOLOGY,7.
MLA Cui, Yajuan,et al."CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia".JOURNAL OF HEMATOLOGY & ONCOLOGY 7(2014).
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