IR@PKUHSC  > 北京大学深圳医院  > 肾内科
学科主题临床医学
Integrin beta 4 in EMT: an implication of renal diseases
Wang, Qi; Wang, Yan; Huang, Xiaoyan; Liang, Wei; Xiong, Zibo; Xiong, Zuying
关键词Integrin beta 4 PPAR gamma EMT renal diseases
刊名INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2015
8期:5页:6967-6976
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]EPITHELIAL-MESENCHYMAL TRANSITION ; TGF-BETA ; ALPHA-6-BETA-4 INTEGRIN ; TUBULOINTERSTITIAL FIBROSIS ; UP-REGULATION ; CARCINOMA ; GROWTH ; ACTIVATION ; EXPRESSION ; INVASION
英文摘要

Renal fibrosis is a main cause of chronic renal failure. Epithelial-to-mesenchymal transition (EMT) markers play a role in renal fibrosis. Transforming growth factor-beta 1 (TGF-beta 1) has been shown to initiate and complete the whole EMT process. It is now well accepted that loss of E-cadherin, EMT marker alpha-SMA, and connective tissue growth factor (CTGF) expression are key events in the EMT process. We found that by stimulating human renal proximal tubular epithelial (HK-2) cells with TGF-beta 1, the expression of E-cadherin was down regulated and the expression of alpha-SMA and CTGF were up regulated in a dose dependent manner. In our present study we also found that integrin beta 4 and peroxisome proliferators-activated receptor-gamma (PPAR-gamma) play roles in EMT process, with TGF-beta 1 stimulation increasing integrin beta 4 expression in HK2 cells. Integrin beta 4 and PPAR gamma were detected in tubulointerstitial tissues, immunohistochemistry analysis showed enhanced expression of integrin beta 4 in early stage, with over-expression at later stage. In contrast, the expression of PPAR gamma showed little increased in early stage, but was dramatically decreased at later stage. This is consistent with TGF-beta 1 inducing EMT. Our immune-precipitation studies show that integrin beta 4 disassociation with PPAR gamma is present in E-cadherin signaling. It suggests that PPAR gamma has a role in EMT inhibition.

语种英语
WOS记录号WOS:000359293200033
项目编号S2013040015040
资助机构Natural Science Foundation of Guangdong Province ; Shenzhen Branch Trade Industry and Information Commission
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58797
专题北京大学深圳医院_肾内科
作者单位Peking Univ, Shenzhen Hosp, Dept Nephrol, Shenzhen 518036, Peoples R China
推荐引用方式
GB/T 7714
Wang, Qi,Wang, Yan,Huang, Xiaoyan,et al. Integrin beta 4 in EMT: an implication of renal diseases[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2015,8(5):6967-6976.
APA Wang, Qi,Wang, Yan,Huang, Xiaoyan,Liang, Wei,Xiong, Zibo,&Xiong, Zuying.(2015).Integrin beta 4 in EMT: an implication of renal diseases.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,8(5),6967-6976.
MLA Wang, Qi,et al."Integrin beta 4 in EMT: an implication of renal diseases".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 8.5(2015):6967-6976.
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