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学科主题: 临床医学
题名:
Integrin beta 4 in EMT: an implication of renal diseases
作者: Wang, Qi; Wang, Yan; Huang, Xiaoyan; Liang, Wei; Xiong, Zibo; Xiong, Zuying
关键词: Integrin beta 4 ; PPAR gamma ; EMT ; renal diseases
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
发表日期: 2015
卷: 8, 期:5, 页:6967-6976
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: EPITHELIAL-MESENCHYMAL TRANSITION ; TGF-BETA ; ALPHA-6-BETA-4 INTEGRIN ; TUBULOINTERSTITIAL FIBROSIS ; UP-REGULATION ; CARCINOMA ; GROWTH ; ACTIVATION ; EXPRESSION ; INVASION
英文摘要:

Renal fibrosis is a main cause of chronic renal failure. Epithelial-to-mesenchymal transition (EMT) markers play a role in renal fibrosis. Transforming growth factor-beta 1 (TGF-beta 1) has been shown to initiate and complete the whole EMT process. It is now well accepted that loss of E-cadherin, EMT marker alpha-SMA, and connective tissue growth factor (CTGF) expression are key events in the EMT process. We found that by stimulating human renal proximal tubular epithelial (HK-2) cells with TGF-beta 1, the expression of E-cadherin was down regulated and the expression of alpha-SMA and CTGF were up regulated in a dose dependent manner. In our present study we also found that integrin beta 4 and peroxisome proliferators-activated receptor-gamma (PPAR-gamma) play roles in EMT process, with TGF-beta 1 stimulation increasing integrin beta 4 expression in HK2 cells. Integrin beta 4 and PPAR gamma were detected in tubulointerstitial tissues, immunohistochemistry analysis showed enhanced expression of integrin beta 4 in early stage, with over-expression at later stage. In contrast, the expression of PPAR gamma showed little increased in early stage, but was dramatically decreased at later stage. This is consistent with TGF-beta 1 inducing EMT. Our immune-precipitation studies show that integrin beta 4 disassociation with PPAR gamma is present in E-cadherin signaling. It suggests that PPAR gamma has a role in EMT inhibition.

语种: 英语
所属项目编号: S2013040015040
项目资助者: Natural Science Foundation of Guangdong Province ; Shenzhen Branch Trade Industry and Information Commission
WOS记录号: WOS:000359293200033
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58797
Appears in Collections:北京大学深圳医院_肾内科_期刊论文

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作者单位: Peking Univ, Shenzhen Hosp, Dept Nephrol, Shenzhen 518036, Peoples R China

Recommended Citation:
Wang, Qi,Wang, Yan,Huang, Xiaoyan,et al. Integrin beta 4 in EMT: an implication of renal diseases[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2015,8(5):6967-6976.
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