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学科主题: 临床医学
题名:
beta-adrenoceptors potentiate alpha(1),-adrenoceptor-mediated inotropic response in rat left atria
作者: Zhang, YZ; Zhang, YY; Chen, MZ; Han, QD
关键词: alpha-1adrenergic receptors ; beta adrenergic receptors ; heart atrium ; cardiac inotropism ; inositol phosphates ; adrenergic receptor antagonists ; adrenergic agonists
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2004
卷: 25, 期:1, 页:29-34
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: ALPHA-ADRENOCEPTOR ; STIMULATION ; CARDIOMYOCYTES
英文摘要:

AIM: To investigate whether stimulation of beta-adrenoceptor (AR) and its subtypes augment alpha(1)-AR-evoked positive inotropic response and inositol phosphate (InsP) accumulation in isolated rat left atria. METHODS: Inotropic response was determined by contractile function experiment in isolated electrically driven rat left atria. H-3-InsP accumulations were measured by H-3-inositol incorporation and column chromatography. RESULTS: (1) Stimulation of alpha(1)-AR by phenylephrine (PE) or norepinephrine (NE) in the presence of propranolol (Prop) evoked positive inotropic response and H-3-InsP accumulations, while stimulation of beta-AR by isoprenaline (ISO) or NE in the presence of phentolamine (Phen) only evoked positive inotropic response, but not H-3-InsP accumulations. (2) Simultaneous stimulation of alpha(1)- and beta-AR by NE or ISO plus PE significantly shifted the concentration-dependent inotropic response curves and H-3-InsP accumulation curves to the left and upward compared with individual alpha(1)-AR stimulation by PE or NE in the presence of Prop. (3) In the presence of IC1118551 (selective beta(2)-AR antagonist) or CGP12177 (selective beta(1)-AR antagonist), stimulation of either beta(1)- or beta(2)-AR did not change alpha(1)-AR-evoked inotropic response and H-3-InsP accumulations. CONCLUSION: Stimulation of beta(1)-AR and beta(2)-AR potentiates alpha(1)-AR-mediated positive inotropic response and InsP accumulation in isolated rat left atria.

语种: 英语
WOS记录号: WOS:000187915700005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58803
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: Peking Univ, Hosp 3, Inst Vasc Med, Key Lab Minist Educ Mol Cardiovasol, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, YZ,Zhang, YY,Chen, MZ,et al. beta-adrenoceptors potentiate alpha(1),-adrenoceptor-mediated inotropic response in rat left atria[J]. ACTA PHARMACOLOGICA SINICA,2004,25(1):29-34.
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