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Determination of echinacoside in rat serum by reversed-phase high-performance liquid chromatography with ultraviolet detection and its application to pharmacokinetics and bioavailability
Jia, Cunqin; Shi, Haiming; Wu, Xiangmei; Li, Yinzeng; Chen, Jingjing; Tu, Pengfei
关键词echinacoside pharmacokinetics bioavailability HPLC phenylethanoid glycoside
刊名JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
2006-12-05
DOI10.1016/j.jchromb.2006.07.040
844期:2页:308-313
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]PHENYLPROPANOID GLYCOSIDES ; PHENYLETHANOID GLYCOSIDES ; ANTIOXIDANT ACTIVITY ; PHENOLIC-COMPOUNDS ; ALKYLAMIDES
英文摘要

A rapid and simple high-performance liquid chromatographic (HPLC) method has been developed and validated for the determination of echinacoside (ECH) in rat serum. After protein precipitation of serum sample with trichloroacetic acid, the supernatant was directly injected and analyzed on a C-18 CapcellACR analytical column (150 mm x 4.6 mm I.D. 5 mu m) with a mobile phase consisting of acetonitrile-0.5% acetic acid (15.5:84.5, v/v). The UV detector was set at 330 nm. The lower limit of detection and quantification were 9 and 29.2 ng/mL, respectively, and the calibration curves were linear over the concentration range of 29.2-18250 ng/mL. The assay method was successfully applied to the study of the pharmacokinetics and bioavailability of ECH in rat. (c) 2006 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000242843900015
引用统计
被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58809
专题北京大学药学院_天然药物学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Nat Med, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Jia, Cunqin,Shi, Haiming,Wu, Xiangmei,et al. Determination of echinacoside in rat serum by reversed-phase high-performance liquid chromatography with ultraviolet detection and its application to pharmacokinetics and bioavailability[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2006,844(2):308-313.
APA Jia, Cunqin,Shi, Haiming,Wu, Xiangmei,Li, Yinzeng,Chen, Jingjing,&Tu, Pengfei.(2006).Determination of echinacoside in rat serum by reversed-phase high-performance liquid chromatography with ultraviolet detection and its application to pharmacokinetics and bioavailability.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,844(2),308-313.
MLA Jia, Cunqin,et al."Determination of echinacoside in rat serum by reversed-phase high-performance liquid chromatography with ultraviolet detection and its application to pharmacokinetics and bioavailability".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 844.2(2006):308-313.
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