IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Effects of Long-Term Stress and Recovery on the Prefrontal Cortex and Dentate Gyrus in Male and Female Rats
Lin, Yanhua1,2,3; Westenbroek, Christel1; Bakker, Petra1; Termeer, Joan1; Liu, Aihua2,3; Li, Xuejun2,3; Ter Horst, Gert J.1
刊名CEREBRAL CORTEX
2008-12-01
DOI10.1093/cercor/bhn035
18期:12页:2762-2774
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]ELEMENT-BINDING PROTEIN ; SEX-DIFFERENCES ; NEUROPSYCHIATRIC DISORDERS ; PYRAMIDAL NEURONS ; PROLONGED STRESS ; RESTRAINT STRESS ; GENE-EXPRESSION ; BRAIN STRUCTURE ; MESSENGER-RNA ; ADRENAL AXIS
英文摘要

Women show a higher prevalence for depression than men. However, the biological basis of gender differences in stress response and recovery still remain poorly understood. Therefore, the aim of the study was to assess the gender differences in response to acute stress, chronic stress and recovery in rats. Our results showed that stress decreased male body weight but had no effect on female rats. Open field test demonstrated behavioral changes in grooming and velocity after chronic stress and recovery. Increased activity of hypothalamic-pituitary-adrenocortical axis was reflected by adrenal hypertrophy and increase of plasma corticosterone levels except in the socially housed female rats after stress. Gender and brain region differences in response to stress and recovery were found in the expression of cAMP response element-binding protein (CREB) and phosphorylated CREB (pCREB). On the whole, expression of CREB and pCREB in male dentate gyrus (DG) and prefrontal cortex (PFC) was sensitive but in female DG and PFC it was resistant to acute and chronic stress. Interestingly, recovery restored the measured parameters to the normal level in male rats but not in female rats. In conclusion, these results suggest that male and female rats responded to stress and recovery in a different way.

语种英语
WOS记录号WOS:000260973800005
资助机构University of Groningen
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58810
专题北京大学基础医学院_药理学系
北京大学基础医学院
作者单位1.Univ Groningen, Dept Psychiat, Univ Med Ctr Groningen, Grad Sch Behav & Cognit Neurosci, NL-9700 RB Groningen, Netherlands
2.Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100083, Peoples R China
3.Peking Univ, Dept Pharmacol, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Lin, Yanhua,Westenbroek, Christel,Bakker, Petra,et al. Effects of Long-Term Stress and Recovery on the Prefrontal Cortex and Dentate Gyrus in Male and Female Rats[J]. CEREBRAL CORTEX,2008,18(12):2762-2774.
APA Lin, Yanhua.,Westenbroek, Christel.,Bakker, Petra.,Termeer, Joan.,Liu, Aihua.,...&Ter Horst, Gert J..(2008).Effects of Long-Term Stress and Recovery on the Prefrontal Cortex and Dentate Gyrus in Male and Female Rats.CEREBRAL CORTEX,18(12),2762-2774.
MLA Lin, Yanhua,et al."Effects of Long-Term Stress and Recovery on the Prefrontal Cortex and Dentate Gyrus in Male and Female Rats".CEREBRAL CORTEX 18.12(2008):2762-2774.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Effects of Long-Term(1314KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Lin, Yanhua]的文章
[Westenbroek, Christel]的文章
[Bakker, Petra]的文章
百度学术
百度学术中相似的文章
[Lin, Yanhua]的文章
[Westenbroek, Christel]的文章
[Bakker, Petra]的文章
必应学术
必应学术中相似的文章
[Lin, Yanhua]的文章
[Westenbroek, Christel]的文章
[Bakker, Petra]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Effects of Long-Term Stress and Recovery on the Prefrontal Cortex and Dentate Gyrus in Male and Female Rats.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。