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学科主题: 基础医学
题名:
Effects of Long-Term Stress and Recovery on the Prefrontal Cortex and Dentate Gyrus in Male and Female Rats
作者: Lin, Yanhua1,2,3; Westenbroek, Christel1; Bakker, Petra1; Termeer, Joan1; Liu, Aihua2,3; Li, Xuejun2,3; Ter Horst, Gert J.1
刊名: CEREBRAL CORTEX
发表日期: 2008-12-01
DOI: 10.1093/cercor/bhn035
卷: 18, 期:12, 页:2762-2774
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: ELEMENT-BINDING PROTEIN ; SEX-DIFFERENCES ; NEUROPSYCHIATRIC DISORDERS ; PYRAMIDAL NEURONS ; PROLONGED STRESS ; RESTRAINT STRESS ; GENE-EXPRESSION ; BRAIN STRUCTURE ; MESSENGER-RNA ; ADRENAL AXIS
英文摘要:

Women show a higher prevalence for depression than men. However, the biological basis of gender differences in stress response and recovery still remain poorly understood. Therefore, the aim of the study was to assess the gender differences in response to acute stress, chronic stress and recovery in rats. Our results showed that stress decreased male body weight but had no effect on female rats. Open field test demonstrated behavioral changes in grooming and velocity after chronic stress and recovery. Increased activity of hypothalamic-pituitary-adrenocortical axis was reflected by adrenal hypertrophy and increase of plasma corticosterone levels except in the socially housed female rats after stress. Gender and brain region differences in response to stress and recovery were found in the expression of cAMP response element-binding protein (CREB) and phosphorylated CREB (pCREB). On the whole, expression of CREB and pCREB in male dentate gyrus (DG) and prefrontal cortex (PFC) was sensitive but in female DG and PFC it was resistant to acute and chronic stress. Interestingly, recovery restored the measured parameters to the normal level in male rats but not in female rats. In conclusion, these results suggest that male and female rats responded to stress and recovery in a different way.

语种: 英语
项目资助者: University of Groningen
WOS记录号: WOS:000260973800005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58810
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Univ Groningen, Dept Psychiat, Univ Med Ctr Groningen, Grad Sch Behav & Cognit Neurosci, NL-9700 RB Groningen, Netherlands
2.Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100083, Peoples R China
3.Peking Univ, Dept Pharmacol, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Lin, Yanhua,Westenbroek, Christel,Bakker, Petra,et al. Effects of Long-Term Stress and Recovery on the Prefrontal Cortex and Dentate Gyrus in Male and Female Rats[J]. CEREBRAL CORTEX,2008,18(12):2762-2774.
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