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学科主题临床医学
Antineutrophil cytoplasmic autoantibody-associated vasculitis in older patients
Chen, Min; Yin, Feng; Zhang, Ying; Zhao, Ming-Hui1
刊名MEDICINE
2008-07-01
DOI10.1097/MD.0b013e31817c744b
87期:4页:203-209
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]ANCA-ASSOCIATED VASCULITIS ; PATHOLOGICAL CHARACTERISTICS ; SYSTEMIC VASCULITIDES ; RENAL VASCULITIS ; CHINESE PATIENTS ; DISEASE
英文摘要

Antineutrophil cytoplasmic autoantibody (ANCA)associated vasculitis (AAV) is increasingly recognized in older patients. The differences in disease presentation and outcome between older and younger patients remain controversial. We conducted the current study to analyze the characteristics of patients aged over 65 years with AAV and to compare the younger and older cohorts. We recruited 234 consecutive Chinese patients with AAV. We compared clinical and pathologic characteristics as well as outcomes between younger and older patients. Among the 234 patient,; with AAV, 99 were older than 65 years. Compared with the 135 younger patients, the older patients had a significantly higher proportion of positive myeloperoxidase-ANCA (94.9% vs. 80.0%, p < 0.01) and a higher proportion of microscopic polyangiitis (79.8% vs. 50.4%, chi(2) = 11.8, p < 0.001), but had a lower proportion of Wegener granulomatosis (18.2% vs. 37.8%, p < 0.01) and renal-limited vasculitis (0% vs. 11.1%, p < 0.001).

Older patients had more prevalent and severe pulmonary involvement than Younger patients, including pulmonary infiltration, interstitial fibrosis, and mechanical ventilation dependence at presentation (47.5% vs. 31.9%, p < 0.05; 37.4% vs. 18.5%, p < 0.01; and 9.1% vs. 1.5%, p < 0.05, respectively). Older patients were less likely to respond to treatment (p < 0.01) and had worse survival than younger patients (p = 0.000). During follow-tip, older patients had a higher risk of secondary pulmonary infection (p < 0.001), and those with pulmonary interstitial fibrosis were more likely to develop secondary pulmonary infections (p < 0.05). In Conclusion, compared with younger patients, older patients with AAV had more severe and more prevalent Pulmonary lesions, which might contribute to Subsequent pulmonary infections after the initiation of immunosuppressive therapy. Age and pulmonary infection were independent predictors of death.

语种英语
WOS记录号WOS:000257894100003
Citation statistics
Cited Times:60[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58811
Collection北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
3.Peking Univ First Hosp, Dept Med, Div Renal, Beijing 100034, Peoples R China
Recommended Citation
GB/T 7714
Chen, Min,Yin, Feng,Zhang, Ying,et al. Antineutrophil cytoplasmic autoantibody-associated vasculitis in older patients[J]. MEDICINE,2008,87(4):203-209.
APA Chen, Min,Yin, Feng,Zhang, Ying,&Zhao, Ming-Hui.(2008).Antineutrophil cytoplasmic autoantibody-associated vasculitis in older patients.MEDICINE,87(4),203-209.
MLA Chen, Min,et al."Antineutrophil cytoplasmic autoantibody-associated vasculitis in older patients".MEDICINE 87.4(2008):203-209.
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