IR@PKUHSC  > 北京大学第一临床医学院  > 感染疾病科
学科主题临床医学
Current Challenges and the Management of Chronic Hepatitis C in Mainland China
Duan, Zhongping1; Jia, Ji-Dong2; Hou, Jinlin7; Lou, Lillian8; Tobias, Hillel9; Xu, Xiao Yuan3; Wei, Lai4; Zhuang, Hui5,6; Pan, Calvin Q.9
关键词disease prevalence China HCV standard of care unmet need disease burden
刊名JOURNAL OF CLINICAL GASTROENTEROLOGY
2014-09-01
48期:8页:679-686
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]PEGYLATED-INTERFERON-ALPHA ; INDUCED VIRAL CLEARANCE ; BLOOD-DONORS ; VIRUS-INFECTION ; RIBAVIRIN THERAPY ; GENETIC-VARIATION ; SOUTHWEST CHINA ; RISK-FACTORS ; GENOTYPE 1 ; PREVALENCE
英文摘要

Despite decreasing prevalence, new cases of hepatitis C in China are increasing recently with growing percentage of patients who are with advanced disease, aging, or not eligible for interferon-based treatments. Hepatitis C infection represents a serious public health burden. This review was based on expert′s consensus during a medical forum on hepatitis sponsored by the Beijing Wu Jie-Ping Medical Foundation. The literature searches were conducted in PubMed and critical publications in Chinese journals. Data on hepatitis C prevalence, risk factors, viral or host features, and treatment modalities were extracted and reviewed. Recent large-scale surveys reported reducing prevalence of hepatitis C to approximately 0.4% in China, partly because of regulation changes to safer medical practices and illegalizing commercial blood donations. Patient demographics evolved from being dominated by former paid blood donors to include intravenous drug users and others. Although hepatitis C genotype 1 is the most common, other genotypes are emerging in prevalence. The current standard of care is interferon-based without direct acting antivirals. However, many patients failed therapy because of high treatment costs, substantial needs to manage side effects, difficulties with treatment monitoring in the rural areas, and growing populations of elderly and cirrhotic patients. The lack of high efficacy therapies with good safety profile and low disease awareness in China resulted in increasing public burden of advanced hepatitis C disease. Despite significant reduction of hepatitis C prevalence, iatrogenic, nosocomial, and community transmissions are still significant. In addition to promoting disease awareness, interferon-free regimens are needed to reduce the public health burden.

语种英语
WOS记录号WOS:000340729100008
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58812
专题北京大学第一临床医学院_感染疾病科
作者单位1.Hepatitis Consulting Nexus Dev, Palo Alto, CA USA
2.Beijing Youan Hosp, Artificial Liver Ctr, Beijing, Peoples R China
3.Capital Med Univ, Friendship Hosp, Div Hepatol, Beijing, Peoples R China
4.Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100871, Peoples R China
5.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100871, Peoples R China
6.Peking Univ, Hlth Sci Ctr, Sch Basic Med, Dept Microbiol, Beijing 100871, Peoples R China
7.Peking Univ, Hlth Sci Ctr, Sch Basic Med, Ctr Infect Dis, Beijing 100871, Peoples R China
8.Southern Med Univ, Nanfang Hosp, Dept Infect Dis, Guangzhou, Guangdong, Peoples R China
9.NYU, Sch Med, Dept Med, Div Gastroenterol,Langone Med Ctr, New York, NY 11355 USA
推荐引用方式
GB/T 7714
Duan, Zhongping,Jia, Ji-Dong,Hou, Jinlin,et al. Current Challenges and the Management of Chronic Hepatitis C in Mainland China[J]. JOURNAL OF CLINICAL GASTROENTEROLOGY,2014,48(8):679-686.
APA Duan, Zhongping.,Jia, Ji-Dong.,Hou, Jinlin.,Lou, Lillian.,Tobias, Hillel.,...&Pan, Calvin Q..(2014).Current Challenges and the Management of Chronic Hepatitis C in Mainland China.JOURNAL OF CLINICAL GASTROENTEROLOGY,48(8),679-686.
MLA Duan, Zhongping,et al."Current Challenges and the Management of Chronic Hepatitis C in Mainland China".JOURNAL OF CLINICAL GASTROENTEROLOGY 48.8(2014):679-686.
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