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学科主题: 公共卫生
题名:
Association between Maternal COMT Gene Polymorphisms and Fetal Neural Tube Defects Risk in a Chinese Population
作者: Liu, Jufen; Wang, Linlin; Fu, Yunting; Li, Zhiwen; Zhang, Yali; Zhang, Le; Jin, Lei; Ye, Rongwei; Ren, Aiguo
关键词: COMT ; neural tube defects ; tea ; single nucleotide polymorphism ; gene-environment interaction
刊名: BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
发表日期: 2014
DOI: 10.1002/bdra.23208
卷: 100, 期:1, 页:22-29
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Developmental Biology ; Toxicology
研究领域[WOS]: Developmental Biology ; Toxicology
关键词[WOS]: CATECHOL-O-METHYLTRANSFERASE ; TOTAL HOMOCYSTEINE LEVELS ; PLACENTAL CONCENTRATIONS ; SHANXI PROVINCE ; HIGH PREVALENCE ; TEA DRINKING ; FOLIC-ACID ; PREVENTION ; SUPPLEMENTATION ; DISEASE
英文摘要:

Background: Maternal tea consumption was reported to increase the risk of fetal neural tube defects (NTDs). Catechol-O-methyltransferase (COMT) may be involved in the metabolism of polyphenolic methylation of tea, thus influence the risk of fetal NTDs. Methods: A total of 576 fetuses or newborns with NTDs and 594 healthy newborns were included in the case-control study. Information on maternal tea consumption, sociodemographic characteristics, reproductive history, and related behavior was collected through face-to-face interviews. Maternal blood samples were collected to examine polymorphisms in COMT, and the possible interaction of COMT and tea consumption was analyzed. RESULTS: After controlling for potential confounders, homozygotes of rs737865 showed an elevated risk for total NTDs (odds ratio [OR]=2.04, 95% confidence interval [CI], 1.24-3.35) and for the anencephaly subtype (OR=1.99, 95% CI, 1.17-3.39). The CC genotype of rs4633 was positively associated with the overall risk of NTDs (OR=3.66, 95% CI, 1.05-12.83). Heterozygotes for rs4680 were associated with a decreased risk of spina bifida (OR=0.71, 95% CI, 0.51-0.98). The COMT rs4680 A allele was negatively related with the risk of spina bifida, with adjusted OR=0.64 (95% CI, 0.45-0.89). An interaction between tea consumption (1 to 2 cups/day) and the rs4680AA/AG genotype was found in the spina bifida subtype (P-interaction=.08). Conclusion: Several COMT variants were associated with elevated risk of NTDs in a Chinese population. Maternal tea consumption may be associated with an increased risk for fetal NTDs in genetically susceptible subgroups. Birth Defects Research (Part A) 100:22-29, 2014. (c) 2013 Wiley Periodicals, Inc.

语种: 英语
所属项目编号: 81202265 ; 31071315 ; BMU20100089
项目资助者: National Natural Science Foundation of China ; Peking University Health Science Center Young Teacher Startup
WOS记录号: WOS:000331064600004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58815
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Inst Reprod & Child Hlth,Minist Hlth,Key Lab Repr, Beijing 100191, Peoples R China

Recommended Citation:
Liu, Jufen,Wang, Linlin,Fu, Yunting,et al. Association between Maternal COMT Gene Polymorphisms and Fetal Neural Tube Defects Risk in a Chinese Population[J]. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY,2014,100(1):22-29.
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