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Short-term effects of escitalopram on regional brain function in first-episode drug-naive patients with major depressive disorder assessed by resting-state functional magnetic resonance imaging
Wang, L.1,2; Li, K.3; Zhang, Q.4; Zeng, Y.3; Dai, W.1,2; Su, Y.1,2; Wang, G.4; Tan, Y.5; Jin, Z.3; Yu, X.1,2; Si, T.1,2
关键词major depressive disorder regional homogeneity Antidepressants resting state fMRI
刊名PSYCHOLOGICAL MEDICINE
2014-05-01
DOI10.1017/S0033291713002031
44期:7页:1417-1426
收录类别SCI ; SSCI
文章类型Article
WOS标题词Social Sciences ; Science & Technology
类目[WOS]Psychology, Clinical ; Psychiatry ; Psychology
研究领域[WOS]Psychology ; Psychiatry
关键词[WOS]MOOD REGULATING CIRCUIT ; TREATMENT-RESPONSE ; ANTIDEPRESSANT TREATMENT ; TREATMENT-RESISTANT ; CLINICAL-RESPONSE ; FMRI ; CONNECTIVITY ; HOMOGENEITY ; MODEL ; MRI
英文摘要

Background

Most knowledge regarding the effects of antidepressant drugs is at the receptor level, distal from the nervous system effects that mediate their clinical efficacy. Using functional magnetic resonance imaging (fMRI), this study investigated the effects of escitalopram, a selective serotonin reuptake inhibitor (SSRI), on resting-state brain function in patients with major depressive disorder (MDD).

Method

Fourteen first-episode drug-naive MDD patients completed two fMRI scans before and after 8 weeks of escitalopram therapy. Scans were also acquired in 14 matched healthy subjects. Data were analyzed using the regional homogeneity (ReHo) approach.

Results

Compared to controls, MDD patients before treatment demonstrated decreased ReHo in the frontal (right superior frontal gyrus), temporal (left middle and right inferior temporal gyri), parietal (right precuneus) and occipital (left superior occipital gyrus and right cuneus) cortices, and increased ReHo in the left dorsal medial prefrontal gyrus and left anterior lobe of the cerebellum. Compared to the unmedicated state, ReHo in the patients after treatment was decreased in the left dorsal medial prefrontal gyrus, the right insula and the bilateral thalamus, and increased in the right superior frontal gyrus. Compared to controls, patients after treatment displayed a ReHo decrease in the right precuneus and a ReHo increase in the left anterior lobe of the cerebellum.

Conclusions

Successful treatment with escitalopram may be associated with modulation of resting-state brain activity in regions within the fronto-limbic circuit. This study provides new insight into the effects of antidepressants on functional brain systems in MDD.

语种英语
WOS记录号WOS:000333560500008
项目编号2013CB531305 ; 2012CB720704
资助机构National Key Basic Research Program of China (973 Program) ; Capital Foundation of Medicine Research and Development
引用统计
被引频次:65[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58817
专题北京大学精神卫生研究所
北京大学精神卫生研究所_精神科
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
3.306 Hosp Peoples Liberat Army, Dept Radiol, Beijing, Peoples R China
4.Capital Med Univ, Beijing Anding Hosp, Mood Disorders Ctr, Beijing, Peoples R China
5.Beijing Huilongguan Hosp, Ctr Psychiat Res, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Wang, L.,Li, K.,Zhang, Q.,et al. Short-term effects of escitalopram on regional brain function in first-episode drug-naive patients with major depressive disorder assessed by resting-state functional magnetic resonance imaging[J]. PSYCHOLOGICAL MEDICINE,2014,44(7):1417-1426.
APA Wang, L..,Li, K..,Zhang, Q..,Zeng, Y..,Dai, W..,...&Si, T..(2014).Short-term effects of escitalopram on regional brain function in first-episode drug-naive patients with major depressive disorder assessed by resting-state functional magnetic resonance imaging.PSYCHOLOGICAL MEDICINE,44(7),1417-1426.
MLA Wang, L.,et al."Short-term effects of escitalopram on regional brain function in first-episode drug-naive patients with major depressive disorder assessed by resting-state functional magnetic resonance imaging".PSYCHOLOGICAL MEDICINE 44.7(2014):1417-1426.
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