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学科主题: 精神卫生
题名:
Short-term effects of escitalopram on regional brain function in first-episode drug-naive patients with major depressive disorder assessed by resting-state functional magnetic resonance imaging
作者: Wang, L.1,2; Li, K.3; Zhang, Q.4; Zeng, Y.3; Dai, W.1,2; Su, Y.1,2; Wang, G.4; Tan, Y.5; Jin, Z.3; Yu, X.1,2; Si, T.1,2
关键词: major depressive disorder ; regional homogeneity ; Antidepressants ; resting state ; fMRI
刊名: PSYCHOLOGICAL MEDICINE
发表日期: 2014-05-01
DOI: 10.1017/S0033291713002031
卷: 44, 期:7, 页:1417-1426
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Social Sciences ; Science & Technology
类目[WOS]: Psychology, Clinical ; Psychiatry ; Psychology
研究领域[WOS]: Psychology ; Psychiatry
关键词[WOS]: MOOD REGULATING CIRCUIT ; TREATMENT-RESPONSE ; ANTIDEPRESSANT TREATMENT ; TREATMENT-RESISTANT ; CLINICAL-RESPONSE ; FMRI ; CONNECTIVITY ; HOMOGENEITY ; MODEL ; MRI
英文摘要:

Background

Most knowledge regarding the effects of antidepressant drugs is at the receptor level, distal from the nervous system effects that mediate their clinical efficacy. Using functional magnetic resonance imaging (fMRI), this study investigated the effects of escitalopram, a selective serotonin reuptake inhibitor (SSRI), on resting-state brain function in patients with major depressive disorder (MDD).

Method

Fourteen first-episode drug-naive MDD patients completed two fMRI scans before and after 8 weeks of escitalopram therapy. Scans were also acquired in 14 matched healthy subjects. Data were analyzed using the regional homogeneity (ReHo) approach.

Results

Compared to controls, MDD patients before treatment demonstrated decreased ReHo in the frontal (right superior frontal gyrus), temporal (left middle and right inferior temporal gyri), parietal (right precuneus) and occipital (left superior occipital gyrus and right cuneus) cortices, and increased ReHo in the left dorsal medial prefrontal gyrus and left anterior lobe of the cerebellum. Compared to the unmedicated state, ReHo in the patients after treatment was decreased in the left dorsal medial prefrontal gyrus, the right insula and the bilateral thalamus, and increased in the right superior frontal gyrus. Compared to controls, patients after treatment displayed a ReHo decrease in the right precuneus and a ReHo increase in the left anterior lobe of the cerebellum.

Conclusions

Successful treatment with escitalopram may be associated with modulation of resting-state brain activity in regions within the fronto-limbic circuit. This study provides new insight into the effects of antidepressants on functional brain systems in MDD.

语种: 英语
所属项目编号: 2013CB531305 ; 2012CB720704
项目资助者: National Key Basic Research Program of China (973 Program) ; Capital Foundation of Medicine Research and Development
WOS记录号: WOS:000333560500008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58817
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
3.306 Hosp Peoples Liberat Army, Dept Radiol, Beijing, Peoples R China
4.Capital Med Univ, Beijing Anding Hosp, Mood Disorders Ctr, Beijing, Peoples R China
5.Beijing Huilongguan Hosp, Ctr Psychiat Res, Beijing, Peoples R China

Recommended Citation:
Wang, L.,Li, K.,Zhang, Q.,et al. Short-term effects of escitalopram on regional brain function in first-episode drug-naive patients with major depressive disorder assessed by resting-state functional magnetic resonance imaging[J]. PSYCHOLOGICAL MEDICINE,2014,44(7):1417-1426.
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