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学科主题口腔医学
Current Understanding of Pathogenesis and Treatment of TMJ Osteoarthritis
Wang, X. D.1,2; Zhang, J. N.1,2; Gan, Y. H.3,4; Zhou, Y. H.1,2
关键词temporomandibular joint temporomandibular disorders mandibular condyle bone remodeling cartilage inflammation
刊名JOURNAL OF DENTAL RESEARCH
2015-05-01
DOI10.1177/0022034515574770
94期:5页:666-673
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]TEMPOROMANDIBULAR-JOINT OSTEOARTHRITIS ; CANCELLOUS BONE REPAIR ; MESENCHYMAL STEM-CELLS ; CONE-BEAM CT ; SUBCHONDRAL BONE ; CARTILAGE DEGENERATION ; ARTICULAR-CARTILAGE ; MANDIBULAR CONDYLE ; MECHANICAL-STRESS ; INFLAMMATION
英文摘要

Osteoarthritis is a common disease that can cause severe pain and dysfunction in any joint, including the temporomandibular joint (TMJ). TMJ osteoarthritis (TMJOA) is an important subtype in the classification of temporomandibular disorders. TMJOA pathology is characterized by progressive cartilage degradation, subchondral bone remodeling, and chronic inflammation in the synovial tissue. However, the exact pathogenesis and process of TMJOA remain to be understood. An increasing number of studies have recently focused on inflammation and remodeling of subchondral bone during the early stage of TMJOA, which may elucidate the possible mechanism of initiation and progression of TMJOA. The treatment strategy for TMJOA aims at relieving pain, preventing the progression of cartilage and subchondral bone destruction, and restoring joint function. Conservative therapy with nonsteroidal anti-inflammatory drugs, splint, and physical therapy, such as low-energy laser and arthrocentesis, are the most common treatments for TMJOA. These therapies are effective in most cases in relieving the signs and symptoms, but their long-term therapeutic effect on the pathologic articular structure is unsatisfactory. A treatment that can reverse the damage of TMJOA remains unavailable to date. Treatments that prevent the progression of cartilage degradation and subchondral bone damage should be explored, and regeneration for the TMJ may provide the ideal long-term solution. This review summarizes the current understanding of mechanisms underlying the pathogenesis and treatment of TMJOA.

语种英语
WOS记录号WOS:000353207800005
项目编号2013DFB30360 ; 81300850 ; 81271173
资助机构China International Science and Technology Cooperation ; National Natural Science Foundation of China
引用统计
被引频次:39[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58819
专题北京大学口腔医学院_牙周科
作者单位1.Peking Univ Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
2.Peking Univ Sch & Hosp Stomatol, Ctr Craniofacial Stem Cell Res & Regenerat, Beijing 100081, Peoples R China
3.Peking Univ Sch & Hosp Stomatol, Ctr Temporomandibular Disorders & Oralfacial Pain, Beijing 100081, Peoples R China
4.Peking Univ Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Wang, X. D.,Zhang, J. N.,Gan, Y. H.,et al. Current Understanding of Pathogenesis and Treatment of TMJ Osteoarthritis[J]. JOURNAL OF DENTAL RESEARCH,2015,94(5):666-673.
APA Wang, X. D.,Zhang, J. N.,Gan, Y. H.,&Zhou, Y. H..(2015).Current Understanding of Pathogenesis and Treatment of TMJ Osteoarthritis.JOURNAL OF DENTAL RESEARCH,94(5),666-673.
MLA Wang, X. D.,et al."Current Understanding of Pathogenesis and Treatment of TMJ Osteoarthritis".JOURNAL OF DENTAL RESEARCH 94.5(2015):666-673.
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