北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学口腔医学院  > 牙周科  > 期刊论文
学科主题: 口腔医学
题名:
Current Understanding of Pathogenesis and Treatment of TMJ Osteoarthritis
作者: Wang, X. D.1,2; Zhang, J. N.1,2; Gan, Y. H.3,4; Zhou, Y. H.1,2
关键词: temporomandibular joint ; temporomandibular disorders ; mandibular condyle ; bone remodeling ; cartilage ; inflammation
刊名: JOURNAL OF DENTAL RESEARCH
发表日期: 2015-05-01
DOI: 10.1177/0022034515574770
卷: 94, 期:5, 页:666-673
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: TEMPOROMANDIBULAR-JOINT OSTEOARTHRITIS ; CANCELLOUS BONE REPAIR ; MESENCHYMAL STEM-CELLS ; CONE-BEAM CT ; SUBCHONDRAL BONE ; CARTILAGE DEGENERATION ; ARTICULAR-CARTILAGE ; MANDIBULAR CONDYLE ; MECHANICAL-STRESS ; INFLAMMATION
英文摘要:

Osteoarthritis is a common disease that can cause severe pain and dysfunction in any joint, including the temporomandibular joint (TMJ). TMJ osteoarthritis (TMJOA) is an important subtype in the classification of temporomandibular disorders. TMJOA pathology is characterized by progressive cartilage degradation, subchondral bone remodeling, and chronic inflammation in the synovial tissue. However, the exact pathogenesis and process of TMJOA remain to be understood. An increasing number of studies have recently focused on inflammation and remodeling of subchondral bone during the early stage of TMJOA, which may elucidate the possible mechanism of initiation and progression of TMJOA. The treatment strategy for TMJOA aims at relieving pain, preventing the progression of cartilage and subchondral bone destruction, and restoring joint function. Conservative therapy with nonsteroidal anti-inflammatory drugs, splint, and physical therapy, such as low-energy laser and arthrocentesis, are the most common treatments for TMJOA. These therapies are effective in most cases in relieving the signs and symptoms, but their long-term therapeutic effect on the pathologic articular structure is unsatisfactory. A treatment that can reverse the damage of TMJOA remains unavailable to date. Treatments that prevent the progression of cartilage degradation and subchondral bone damage should be explored, and regeneration for the TMJ may provide the ideal long-term solution. This review summarizes the current understanding of mechanisms underlying the pathogenesis and treatment of TMJOA.

语种: 英语
所属项目编号: 2013DFB30360 ; 81300850 ; 81271173
项目资助者: China International Science and Technology Cooperation ; National Natural Science Foundation of China
WOS记录号: WOS:000353207800005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58819
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
2.Peking Univ Sch & Hosp Stomatol, Ctr Craniofacial Stem Cell Res & Regenerat, Beijing 100081, Peoples R China
3.Peking Univ Sch & Hosp Stomatol, Ctr Temporomandibular Disorders & Oralfacial Pain, Beijing 100081, Peoples R China
4.Peking Univ Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China

Recommended Citation:
Wang, X. D.,Zhang, J. N.,Gan, Y. H.,et al. Current Understanding of Pathogenesis and Treatment of TMJ Osteoarthritis[J]. JOURNAL OF DENTAL RESEARCH,2015,94(5):666-673.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, X. D.]'s Articles
[Zhang, J. N.]'s Articles
[Gan, Y. H.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, X. D.]‘s Articles
[Zhang, J. N.]‘s Articles
[Gan, Y. H.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace