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IR@PKUHSC  > 北京大学第二临床医学院  > 呼吸内科  > 期刊论文
学科主题: 临床医学
题名:
Clinical Characteristics of 26 Human Cases of Highly Pathogenic Avian Influenza A (H5N1) Virus Infection in China
作者: Yu, Hongjie1; Gao, Zhancheng2; Feng, Zijian1; Shu, Yuelong3; Xiang, Nijuan1; Zhou, Lei1; Huai, Yang1; Feng, Luzhao1; Peng, Zhibin1; Li, Zhongjie1; Xu, Cuiling3; Li, Junhua4; Hu, Chengping5; Li, Qun6; Xu, Xiaoling7; Liu, Xuecheng8; Liu, Zigui9; Xu, Longshan10; Chen, Yusheng11; Luo, Huiming12; Wei, Liping13; Zhang, Xianfeng14; Xin, Jianbao15; Guo, Junqiao16; Wang, Qiuyue17; Yuan, Zhengan18; Zhou, Longnv19; Zhang, Kunzhao20; Zhang, Wei21; Yang, Jinye22; Zhong, Xiaoning23; Xia, Shichang24; Li, Lanjuan25; Cheng, Jinquan26; Ma, Erdang27; He, Pingping28; Lee, Shui Shan29; Wang, Yu1; Uyeki, Timothy M.30; Yang, Weizhong1
刊名: PLOS ONE
发表日期: 2008-08-21
DOI: 10.1371/journal.pone.0002985
卷: 3, 期:8
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要:

Background: While human cases of highly pathogenic avian influenza A (H5N1) virus infection continue to increase globally, available clinical data on H5N1 cases are limited. We conducted a retrospective study of 26 confirmed human H5N1 cases identified through surveillance in China from October 2005 through April 2008.

Methodology/Principal Findings: Data were collected from hospital medical records of H5N1 cases and analyzed. The median age was 29 years (range 6-62) and 58% were female. Many H5N1 cases reported fever (92%) and cough (58%) at illness onset, and had lower respiratory findings of tachypnea and dyspnea at admission. All cases progressed rapidly to bilateral pneumonia. Clinical complications included acute respiratory distress syndrome (ARDS, 81%), cardiac failure (50%), elevated aminotransaminases (43%), and renal dysfunction (17%). Fatal cases had a lower median nadir platelet count (64.5x10(9) cells/L vs 93.0x10(9) cells/L, p = 0.02), higher median peak lactic dehydrogenase (LDH) level (1982.5 U/L vs 1230.0 U/L, p = 0.001), higher percentage of ARDS (94% [n = 16] vs 56% [n = 5], p = 0.034) and more frequent cardiac failure (71% [n = 12] vs 11% [n = 1], p = 0.011) than nonfatal cases. A higher proportion of patients who received antiviral drugs survived compared to untreated (67% [8/12] vs 7% [1/14], p = 0.003).

Conclusions/Significance: The clinical course of Chinese H5N1 cases is characterized by fever and cough initially, with rapid progression to lower respiratory disease. Decreased platelet count, elevated LDH level, ARDS and cardiac failure were associated with fatal outcomes. Clinical management of H5N1 cases should be standardized in China to include early antiviral treatment for suspected H5N1 cases.

语种: 英语
所属项目编号: 2004BA519A17 ; 2004BA519A71 ; 2006BAD06A02
项目资助者: Ministry of Science and Technology of China ; China-U.S. Collaborative Program on Emerging and Re-emerging Infectious Diseases
WOS记录号: WOS:000264426800002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58820
Appears in Collections:北京大学第二临床医学院_呼吸内科_期刊论文

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作者单位: 1.Hankou Union Hosp, Wuhan, Peoples R China
2.Liaoning Provincial Ctr Dis Control & Prevent, Shenyang, Peoples R China
3.Shanghai Ctr Dis Control & Prevent, Shanghai, Peoples R China
4.Jiangxi Provincial Ctr Dis Control & Prevent, Nanchang, Peoples R China
5.Guangxi Provincial Ctr Dis Control & Prevent, Nanning, Peoples R China
6.Zhejiang Provincial Ctr Dis Control & Prevent, Hangzhou, Peoples R China
7.Shenzhen Ctr Dis Control & Prevent, Shenzhen, Peoples R China
8.Anhui Provincial Ctr Dis Control & Prevent, Hefei, Peoples R China
9.Hubei Provincial Ctr Dis Control & Prevent, Wuhan, Peoples R China
10.Anhui Provincial Hosp, Hefei, Peoples R China
11.Sichuan Provincial Ctr Dis Control & Prevent, Chengdu, Peoples R China
12.Sichuan Univ, Huaxi Hosp, Chengdu, Peoples R China
13.Fujian Provincial Ctr Dis Control & Prevent, Fuzhou, Peoples R China
14.Fujian Provincial Hosp, Fuzhou, Peoples R China
15.Hunan Provincial Ctr Dis Control & Prevent, Changsha, Peoples R China
16.Cent S Univ, Xiang Ya Hosp, Changsha, Peoples R China
17.Chinese Ctr Dis Control & Prevent China CDC, Off Dis Control & Emergency Response, Beijing, Peoples R China
18.Peking Univ, Peoples Hosp, Dept Resp Med, Beijing, Peoples R China
19.China CDC, Natl Inst Viral Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing, Peoples R China
20.Guangdong Provincial Ctr Dis Control & Prevent, Guangzhou, Peoples R China
21.Guangzhou Med Coll, Third Affiliated Hosp, Guangzhou, Peoples R China
22.China Med Univ, First Affiliated Hosp, Shenyang, Peoples R China
23.Shanghai Transport Univ, Ninth Affiliated Hosp, Shanghai, Peoples R China
24.Nanchang Univ, First Affiliated Hosp, Nanchang, Peoples R China
25.Guangxi Med Univ, First Affiliated Hosp, Nanning, Peoples R China
26.Zhejiang Univ, First Affiliated Hosp, Hangzhou, Peoples R China
27.Xinjiang Uygur Autonomous Region Ctr Dis Control, Urumqi, Peoples R China
28.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing, Peoples R China
29.Chinese Univ Hong Kong, Ctr Emerging Infect Dis, Sha Tin 100083, Peoples R China
30.Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Ctr Emerging Infect Dis, Atlanta, GA USA

Recommended Citation:
Yu, Hongjie,Gao, Zhancheng,Feng, Zijian,et al. Clinical Characteristics of 26 Human Cases of Highly Pathogenic Avian Influenza A (H5N1) Virus Infection in China[J]. PLOS ONE,2008,3(8).
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