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学科主题: 基础医学
题名:
Dietary cholesterol reverses resistance to diet-induced weight gain in mice lacking Niemann-Pick C1-Like 1
作者: Jia, Lin1; Ma, Yinyan1; Liu, George2,3; Yu, Liqing1
关键词: obesity ; intestinal fat absorption ; ezetimibe ; insulin resistance ; hepatic steatosis
刊名: JOURNAL OF LIPID RESEARCH
发表日期: 2010-10-01
DOI: 10.1194/jlr.M008599
卷: 51, 期:10, 页:3024-3033
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: FATTY LIVER-DISEASE ; COA REDUCTASE INHIBITORS ; BINDING PROTEIN-1C GENE ; PRIMARY HYPERCHOLESTEROLEMIA ; ABSORPTION INHIBITOR ; STEROL ABSORPTION ; ENERGY-BALANCE ; EZETIMIBE ; NPC1L1 ; COMBINATION
英文摘要:

Niemann-Pick C1-Like 1 (NPC1L1) mediates intestinal cholesterol absorption. NPC1L1 knockout (L1-KO) mice were recently shown to be resistant to high-fat diet (HFD)-induced obesity in one study, which was contrary to several other studies. Careful comparison of dietary compositions in these studies implies a potential role of dietary cholesterol in regulating weight gain. To examine this potential, wild-type (WT) and L1-KO mice were fed one of three sets of diets for various durations: (1) a HFD without added cholesterol for 5 weeks; (2) a high-carbohydrate diet with or without added cholesterol for 5 weeks; or (3) a synthetic HFD with or without added cholesterol for 18 weeks. We found that L1-KO mice were protected against diet-induced weight gain only on a diet without added cholesterol but not on a diet containing 0.16% or 0.2% (w/w) cholesterol, an amount similar to a typical Western diet, regardless of the major energy source of the diet. Food intake and intestinal fat absorption were similar between the two genotypes. Intestinal cholesterol absorption was blocked, and fecal cholesterol excretion increased in L1-KO mice. Under all diets, L1-KO mice were protected from hepatosteatosis. In conclusion, increasing dietary cholesterol restores diet-induced weight gain in mice deficient in NPC1L1-dependent cholesterol absorption.-Jia, L., Y. Ma, G. Liu, and L. Yu. Dietary cholesterol reverses resistance to diet-induced weight gain in mice lacking Niemann-Pick C1-Like 1. J. Lipid Res. 2010. 51: 3024-3033.

语种: 英语
所属项目编号: R01 DK-085176
项目资助者: American Heart Association ; National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
WOS记录号: WOS:000281756800016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58821
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Wake Forest Univ, Bowman Gray Sch Med, Dept Pathol & Biochem, Winston Salem, NC 27106 USA
2.Peking Univ, Inst Cardiovasc Sci, Hlth Sci Ctr, Beijing 100871, Peoples R China
3.Peking Univ, Key Lab Mol Cardiovasc Sci, Hlth Sci Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Jia, Lin,Ma, Yinyan,Liu, George,et al. Dietary cholesterol reverses resistance to diet-induced weight gain in mice lacking Niemann-Pick C1-Like 1[J]. JOURNAL OF LIPID RESEARCH,2010,51(10):3024-3033.
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