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学科主题临床医学
Polymorphisms and mutations of the folate receptor-alpha gene and risk of gastric cancer in a Chinese population
Zhang, G; Zhang, QY; Miao, XP; Lin, DX; Lu, YY
关键词folate receptor gastric cancer genetic polymorphism susceptibility
刊名INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
2005-04-01
15期:4页:627-632
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]REPRESENTATIONAL DIFFERENCE ANALYSIS ; METHYLENETETRAHYDROFOLATE REDUCTASE ; PLASMA HOMOCYSTEINE ; COLORECTAL-CANCER ; OVARIAN-CARCINOMA ; CELL-TYPE ; EXPRESSION ; DNA ; HYPOMETHYLATION ; CARCINOGENESIS
英文摘要

Folate deficiency is associated with increased risk of many human diseases including several cancers. Folate receptor-alpha (FR-alpha) plays an important role in mediating influx of folates into cells and its expression can be induced by some environmental risk factors. Our previous study showed that decreased expression of FR-alpha Occurs in human gastric cancer cell lines. In order to reveal the molecular mechanism of the difference of FR-alpha expression among these cell lines and analyze the relation between the mutations or/and polymorphisms of FR-alpha gene and gastric cancer, we screened the mutations of global FR-alpha gene in 12 gastric cancer cell lines and 28 gastric tumors and matched normal tissues by using PCR-DHPLC and DNA sequencing techniques, then further checked the exon2 of FR-alpha gene in 138 gastric tumors and matched normal tissues. Furthermore, we examined the relationship between two polymorphisms of FR-alpha A1314G and C1816delC and risk for gastric cancer in 296 cases and 354 age and sex-matched controls in northern China. We found that the allele frequency of FR-alpha 1314A among cases was 7 significantly higher than that among controls (0.186 vs. 0.143, P=0.014). Subjects with the A/G and A/A genotype had an increased risk for developing Gastric cancer compared with the G/G genotype (OR=1.55; 95% CI=1.10-2.17). These results support the hypothesis that genetic polymorphism in the FR-alpha gene may contribute to susceptibility to carcinogenesis of the gastric cancer in the at-risk Chinese population.

语种英语
WOS记录号WOS:000227753700012
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58823
专题北京大学临床肿瘤学院_分子肿瘤学研究室
作者单位1.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Mol Oncol Lab, Beijing 100034, Peoples R China
2.Chinese Acad Med Sci, Inst Canc, Dept Etiol & Carcinogenesis, Beijing 100021, Peoples R China
推荐引用方式
GB/T 7714
Zhang, G,Zhang, QY,Miao, XP,et al. Polymorphisms and mutations of the folate receptor-alpha gene and risk of gastric cancer in a Chinese population[J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2005,15(4):627-632.
APA Zhang, G,Zhang, QY,Miao, XP,Lin, DX,&Lu, YY.(2005).Polymorphisms and mutations of the folate receptor-alpha gene and risk of gastric cancer in a Chinese population.INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,15(4),627-632.
MLA Zhang, G,et al."Polymorphisms and mutations of the folate receptor-alpha gene and risk of gastric cancer in a Chinese population".INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 15.4(2005):627-632.
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