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学科主题: 公共卫生
题名:
Polymer-Doxorubicin Conjugate Micelles Based on Poly(ethylene glycol) and Poly(N-(2-hydroxypropyl) methacrylamide): Effect of Negative Charge and Molecular Weight on Biodistribution and Blood Clearance
作者: Yu, Qingsong1; Wei, Zhenke2; Shi, Jiyun3; Guan, Shuli1; Du, Nan1; Shen, Tong1; Tang, Hao1; Jia, Bing3; Wang, Fan3; Gan, Zhihua1,2
刊名: BIOMACROMOLECULES
发表日期: 2015-09-01
DOI: 10.1021/acs.biomac.5b00460
卷: 16, 期:9, 页:2645-2655
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
关键词[WOS]: IN-VIVO ; GLOMERULAR-FILTRATION ; HPMA COPOLYMERS ; N-(2-HYDROXYPROPYL)METHACRYLAMIDE COPOLYMERS ; TUMOR ACCUMULATION ; BLOCK-COPOLYMERS ; DRUG-DELIVERY ; TOMOGRAPHY ; CANCER ; THERAPEUTICS
英文摘要:

Well-defined water-soluble block copolymers poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide-co-N-methacryloylglycylglycine) (PEG-b-P (HPMA-co-MAGG)) and their doxorubicin (Dox) conjugates with different composition and molecular weight were synthesized. These Dox conjugates can form micelles in buffer solution. The physicochemical properties, in vivo biodistribution, blood clearance, and especially the tumor accumulation of copolymers and micelles were studied. Severe liver accumulation can be observed for PEG-b-PMAGG copolymers. This was quite different from their Dox conjugate for which decreased RES uptake and elevated kidney accumulation could be observed. When decrease the negative charge to an appropriate amount such as 8-10 mol %, both RES uptake and kidney accumulation could be suppressed. Obvious tumor accumulation could be achieved especially when the molecular weight were increased from similar to 40 to similar to 80 KDa. These results provided us with a guideline for the design of nanoscaled drug delivery system as well as a potential option for treating kidney-related cancers.

语种: 英语
所属项目编号: 51390481 ; 51025314 ; 50873109 ; 81472412 ; 30930030 ; 2015M570919
项目资助者: National Natural Science Foundations of China ; China Postdoctoral Foundation ; Ministry of Finance ; Ministry of Education of PRC
WOS记录号: WOS:000361341700010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58824
Appears in Collections:北京大学医药卫生分析中心_期刊论文

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作者单位: 1.Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing Lab Biomed Mat, Coll Life Sci & Technol, Beijing 100029, Peoples R China
2.Chinese Acad Sci, Inst Chem, CAS Key Lab Engn Plast, Beijing 100190, Peoples R China
3.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Yu, Qingsong,Wei, Zhenke,Shi, Jiyun,et al. Polymer-Doxorubicin Conjugate Micelles Based on Poly(ethylene glycol) and Poly(N-(2-hydroxypropyl) methacrylamide): Effect of Negative Charge and Molecular Weight on Biodistribution and Blood Clearance[J]. BIOMACROMOLECULES,2015,16(9):2645-2655.
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