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学科主题: 临床医学
题名:
The gp130/STAT3 signaling pathway mediates beta-adrenergic receptor-induced atrial natriuretic factor expression in cardiomyocytes
作者: Zhang, Hui; Feng, Wei; Liao, Wenqiang; Ma, Xiaowei; Han, Qide; Zhang, Youyi1
关键词: ANF ; beta-adrenergic receptor ; cardiomyocytes ; gp130 ; STAT3
刊名: FEBS JOURNAL
发表日期: 2008-07-01
DOI: 10.1111/j.1742-4658.2008.06504.x
卷: 275, 期:14, 页:3590-3597
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: SERINE PHOSPHORYLATION ; RAT CARDIOMYOCYTES ; CARDIAC MYOCYTES ; ERK ACTIVATION ; STAT3 ; HEART ; TRANSCRIPTION ; HYPERTROPHY ; CARDIOPROTECTION ; STIMULATION
英文摘要:

beta-Adrenergic receptor (beta-AR)-induced cardiac remodeling is closely linked with the re-expression of the atrial natriuretic factor (ANF) gene. However, the exact molecular mechanism of this response remains elusive. Here, we demonstrate that the beta-AR agonist isoproterenol potently evokes the tyrosine phosphorylation of STAT3 and increases its transcriptional activity in an extracellularly regulated kinase 1/2 and glycoprotein (gp)130 signaling-dependent manner in rat cardiomyocytes. Interestingly, both specific silencing of signal transducers and activators of transcription 3 (STAT3) expression by lentivirus-mediated RNA interference and antagonism of gp130 signaling lead to significant inhibition of isoproterenol-stimulated ANF expression. Together, these results indicate that gp130/STAT3 signaling has an essential role in ANF expression by beta-AR stimulation.

语种: 英语
WOS记录号: WOS:000257715900009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58832
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiovas Sci, Beijing, Peoples R China
2.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, Hui,Feng, Wei,Liao, Wenqiang,et al. The gp130/STAT3 signaling pathway mediates beta-adrenergic receptor-induced atrial natriuretic factor expression in cardiomyocytes[J]. FEBS JOURNAL,2008,275(14):3590-3597.
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