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学科主题临床医学
The gp130/STAT3 signaling pathway mediates beta-adrenergic receptor-induced atrial natriuretic factor expression in cardiomyocytes
Zhang, Hui; Feng, Wei; Liao, Wenqiang; Ma, Xiaowei; Han, Qide; Zhang, Youyi1
关键词ANF beta-adrenergic receptor cardiomyocytes gp130 STAT3
刊名FEBS JOURNAL
2008-07-01
DOI10.1111/j.1742-4658.2008.06504.x
275期:14页:3590-3597
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]SERINE PHOSPHORYLATION ; RAT CARDIOMYOCYTES ; CARDIAC MYOCYTES ; ERK ACTIVATION ; STAT3 ; HEART ; TRANSCRIPTION ; HYPERTROPHY ; CARDIOPROTECTION ; STIMULATION
英文摘要

beta-Adrenergic receptor (beta-AR)-induced cardiac remodeling is closely linked with the re-expression of the atrial natriuretic factor (ANF) gene. However, the exact molecular mechanism of this response remains elusive. Here, we demonstrate that the beta-AR agonist isoproterenol potently evokes the tyrosine phosphorylation of STAT3 and increases its transcriptional activity in an extracellularly regulated kinase 1/2 and glycoprotein (gp)130 signaling-dependent manner in rat cardiomyocytes. Interestingly, both specific silencing of signal transducers and activators of transcription 3 (STAT3) expression by lentivirus-mediated RNA interference and antagonism of gp130 signaling lead to significant inhibition of isoproterenol-stimulated ANF expression. Together, these results indicate that gp130/STAT3 signaling has an essential role in ANF expression by beta-AR stimulation.

语种英语
WOS记录号WOS:000257715900009
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58832
专题北京大学第三临床医学院_心血管内科
作者单位1.Minist Educ, Key Lab Mol Cardiovas Sci, Beijing, Peoples R China
2.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100083, Peoples R China
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GB/T 7714
Zhang, Hui,Feng, Wei,Liao, Wenqiang,et al. The gp130/STAT3 signaling pathway mediates beta-adrenergic receptor-induced atrial natriuretic factor expression in cardiomyocytes[J]. FEBS JOURNAL,2008,275(14):3590-3597.
APA Zhang, Hui,Feng, Wei,Liao, Wenqiang,Ma, Xiaowei,Han, Qide,&Zhang, Youyi.(2008).The gp130/STAT3 signaling pathway mediates beta-adrenergic receptor-induced atrial natriuretic factor expression in cardiomyocytes.FEBS JOURNAL,275(14),3590-3597.
MLA Zhang, Hui,et al."The gp130/STAT3 signaling pathway mediates beta-adrenergic receptor-induced atrial natriuretic factor expression in cardiomyocytes".FEBS JOURNAL 275.14(2008):3590-3597.
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