IR@PKUHSC  > 北京大学深圳医院  > 消化内科
学科主题临床医学
Polydatin Ameliorates DSS-Induced Colitis in Mice through Inhibition of Nuclear Factor-kappaB Activation
Yao, Jun1; Wang, Jian-Yao2; Liu, Lei2; Zeng, Wei-Sen3; Li, Ying-Xue1; Xun, An-Ying4; Zhao, Li3; Jia, Chun-Hong3; Feng, Ju-Ling1; Wei, Xiao-Xia1; Wang, Li-Sheng1
关键词nuclear factor-kappa B polydatin resveratrol ulcerative colitis
刊名PLANTA MEDICA
2011-03-01
DOI10.1055/s-0030-1250462
77期:5页:421-427
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
资助者Natural Science Foundation of Guangdong Province, China ; Natural Science Foundation of Guangdong Province, China
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]SODIUM-INDUCED COLITIS ; ULCERATIVE-COLITIS ; COLONIC INFLAMMATION ; B ACTIVATION ; ANTIOXIDANT ; PICEID ; RATS ; RESVERATROL ; GLUCOSIDASE ; DISEASE
英文摘要

Nuclear factor-kappa B (NF-kappa B) plays a pivotal role in the regulation of immune and inflammatory responses. The real-time expression level of NF-kappa B reflects the development of ulcerative colitis (UC). Polydatin has vast pharmacological activities, including inhibiting the production of inflammatory mediators, inducing the production of antioxidants, regulating immune function, etc. The purpose of this study was to investigate the potential inhibitory effects of polydatin on NF-kappa B pathway activation in a mouse UC model. The results showed that polydatin treatment downregulated NF-kappa B p65 activity and expression, blocked the expression of TNF-alpha, IL-6 and IL-1 beta at both mRNA and protein levels, decreased myeloperoxidase (MPO) activity, and alleviated inflammatory damage of colitis in mice with UC (p < 0.05), suggesting that the anti-inflammation effects of polydatin can be attributed, at least partially, to the blocking of the NF-kappa B pathway.

语种英语
所属项目编号8151802001000004
资助者Natural Science Foundation of Guangdong Province, China ; Natural Science Foundation of Guangdong Province, China
WOS记录号WOS:000288847600003
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58836
Collection北京大学深圳医院_消化内科
作者单位1.Jinan Univ Med Sci, Dept Gastroenterol, Shenzhen Municipal Peoples Hosp, Shenzhen 518020, Guangdong, Peoples R China
2.Shenzhen Childrens Hosp, Dept Gen Surg, Shenzhen, Guangdong, Peoples R China
3.So Med Univ, Dept Cell Biol, Guangzhou, Guangdong, Peoples R China
4.Peking Univ, Shenzhen Hosp, Dept Gastroenterol, Shenzhen, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Yao, Jun,Wang, Jian-Yao,Liu, Lei,et al. Polydatin Ameliorates DSS-Induced Colitis in Mice through Inhibition of Nuclear Factor-kappaB Activation[J]. PLANTA MEDICA,2011,77(5):421-427.
APA Yao, Jun.,Wang, Jian-Yao.,Liu, Lei.,Zeng, Wei-Sen.,Li, Ying-Xue.,...&Wang, Li-Sheng.(2011).Polydatin Ameliorates DSS-Induced Colitis in Mice through Inhibition of Nuclear Factor-kappaB Activation.PLANTA MEDICA,77(5),421-427.
MLA Yao, Jun,et al."Polydatin Ameliorates DSS-Induced Colitis in Mice through Inhibition of Nuclear Factor-kappaB Activation".PLANTA MEDICA 77.5(2011):421-427.
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