IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Association of decreased mitochondrial DNA content with ovarian cancer progression
Wang, Y.; Liu, V. W. S.; Xue, W. C.; Cheung, A. N. Y.; Ngan, H. Y. S.
关键词mitochondrial DNA copy number ovarian carcinoma
刊名BRITISH JOURNAL OF CANCER
2006-10-23
DOI10.1038/sj.bjc.6603377
95期:8页:1087-1091
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]COPY NUMBER ; MUTATIONS ; CARCINOMAS ; CELLS ; INCREASE ; GENOME ; KRAS ; BRAF ; P53
英文摘要

Mitochondrial DNA ( mtDNA) content in ovarian carcinomas was assessed by quantitative PCR. Results show that mtDNA content in tumour cell was significantly higher than that in normal ovary. Change in mtDNA content was not related with patients′ age or tumour stages. However, the average mtDNA copy number in pathological low-grade tumours was over two-fold higher than that in high-grade carcinomas (P = 0.012). Moreover, type I carcinomas also had a significantly higher mtDNA copy number than in type II carcinomas (P = 0.019). Change in mtDNA content might be an important genetic event in the progression of ovarian carcinomas.

语种英语
WOS记录号WOS:000241384400022
Citation statistics
Cited Times:79[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58837
Collection北京大学第二临床医学院
作者单位1.Univ Hong Kong, Dept Obstet & Gynecol, Queen Mary Hosp, Hong Kong, Hong Kong, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Pathol, Beijing 100871, Peoples R China
4.Univ Hong Kong, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Wang, Y.,Liu, V. W. S.,Xue, W. C.,et al. Association of decreased mitochondrial DNA content with ovarian cancer progression[J]. BRITISH JOURNAL OF CANCER,2006,95(8):1087-1091.
APA Wang, Y.,Liu, V. W. S.,Xue, W. C.,Cheung, A. N. Y.,&Ngan, H. Y. S..(2006).Association of decreased mitochondrial DNA content with ovarian cancer progression.BRITISH JOURNAL OF CANCER,95(8),1087-1091.
MLA Wang, Y.,et al."Association of decreased mitochondrial DNA content with ovarian cancer progression".BRITISH JOURNAL OF CANCER 95.8(2006):1087-1091.
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