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学科主题: 临床医学
题名:
Association of decreased mitochondrial DNA content with ovarian cancer progression
作者: Wang, Y.; Liu, V. W. S.; Xue, W. C.; Cheung, A. N. Y.; Ngan, H. Y. S.
关键词: mitochondrial DNA ; copy number ; ovarian carcinoma
刊名: BRITISH JOURNAL OF CANCER
发表日期: 2006-10-23
10.1038/sj.bjc.6603377
卷: 95, 期:8, 页:1087-1091
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: COPY NUMBER ; MUTATIONS ; CARCINOMAS ; CELLS ; INCREASE ; GENOME ; KRAS ; BRAF ; P53
英文摘要:

Mitochondrial DNA ( mtDNA) content in ovarian carcinomas was assessed by quantitative PCR. Results show that mtDNA content in tumour cell was significantly higher than that in normal ovary. Change in mtDNA content was not related with patients′ age or tumour stages. However, the average mtDNA copy number in pathological low-grade tumours was over two-fold higher than that in high-grade carcinomas (P = 0.012). Moreover, type I carcinomas also had a significantly higher mtDNA copy number than in type II carcinomas (P = 0.019). Change in mtDNA content might be an important genetic event in the progression of ovarian carcinomas.

语种: 英语
WOS记录号: WOS:000241384400022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58837
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Univ Hong Kong, Dept Obstet & Gynecol, Queen Mary Hosp, Hong Kong, Hong Kong, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Pathol, Beijing 100871, Peoples R China
4.Univ Hong Kong, Dept Pathol, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Wang, Y.,Liu, V. W. S.,Xue, W. C.,et al. Association of decreased mitochondrial DNA content with ovarian cancer progression[J]. BRITISH JOURNAL OF CANCER,2006,95(8):1087-1091.
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