北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科  > 期刊论文
学科主题: 临床医学
题名:
Pathological Significance of a Panel of Urinary Biomarkers in Patients with Drug-Induced Tubulointerstitial Nephritis
作者: Wu, Yu; Yang, Li; Su, Tao; Wang, Chen; Liu, Gang; Li, Xiao-mei1
刊名: CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
发表日期: 2010-11-01
卷: 5, 期:11, 页:1954-1959
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: GELATINASE-ASSOCIATED LIPOCALIN ; CHRONIC KIDNEY-DISEASE ; CARDIAC-SURGERY ; RENAL INJURY ; NEPHROTOXICITY ; PROTEIN ; DYSFUNCTION ; GENTAMICIN ; ENZYMURIA ; CHILDREN
英文摘要:

Background and objectives: Although a renal biopsy is indispensable for depicting the severity of pathologic lesions in drug-induced tubulointerstitial nephritis (DTIN), it is not acceptable in some cases and cannot be performed serially because of its invasive nature. Therefore, the discovery of noninvasive markers that are closely related to the pathology of DTIN is of great value.

Design, setting, participants, & measurements: In this study, the urinary levels of monocyte chemotactic peptide-1 (MCP-1), neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-beta-D-glucosaminidase, and alpha 1-microglobulin were measured in 40 DTIN subjects, and the performances of these parameters for distinguishing different pathologic lesions were compared.

Results: Linear correlation and receiver operating characteristic curve analyses showed that urinary MCP-1 levels were able to identify serious interstitial edema and inflammatory infiltration with greater accuracy than the other biomarkers (r = 0.501, P < 0.001 and r = 0.768, P < 0.001, respectively), whereas urinary NGAL levels showed the highest correlation coefficient with tubular atrophy (r = 0.692, P < 0.001).

Conclusions: These results suggest that these biomarker levels were higher in patients with DTIN than in controls. Urinary MCP-1 levels correlated and were predictive of the gradated severity of acute lesions in DTIN, whereas the roles of NGAL and alpha 1-microglobulin in chronic alterations require further study. Clin J Am Soc Nephrol 5: 1954-1959, 2010. doi: 10.2215/CJN.02370310

语种: 英语
所属项目编号: 2007 BAI04B10
项目资助者: National Key Technologies RD Program
WOS记录号: WOS:000284018500009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58839
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China

Recommended Citation:
Wu, Yu,Yang, Li,Su, Tao,et al. Pathological Significance of a Panel of Urinary Biomarkers in Patients with Drug-Induced Tubulointerstitial Nephritis[J]. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,2010,5(11):1954-1959.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wu, Yu]'s Articles
[Yang, Li]'s Articles
[Su, Tao]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wu, Yu]‘s Articles
[Yang, Li]‘s Articles
[Su, Tao]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace