IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Pathological Significance of a Panel of Urinary Biomarkers in Patients with Drug-Induced Tubulointerstitial Nephritis
Wu, Yu; Yang, Li; Su, Tao; Wang, Chen; Liu, Gang; Li, Xiao-mei1
刊名CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
2010-11-01
5期:11页:1954-1959
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
资助者National Key Technologies RD Program ; National Key Technologies RD Program
研究领域[WOS]Urology & Nephrology
关键词[WOS]GELATINASE-ASSOCIATED LIPOCALIN ; CHRONIC KIDNEY-DISEASE ; CARDIAC-SURGERY ; RENAL INJURY ; NEPHROTOXICITY ; PROTEIN ; DYSFUNCTION ; GENTAMICIN ; ENZYMURIA ; CHILDREN
英文摘要

Background and objectives: Although a renal biopsy is indispensable for depicting the severity of pathologic lesions in drug-induced tubulointerstitial nephritis (DTIN), it is not acceptable in some cases and cannot be performed serially because of its invasive nature. Therefore, the discovery of noninvasive markers that are closely related to the pathology of DTIN is of great value.

Design, setting, participants, & measurements: In this study, the urinary levels of monocyte chemotactic peptide-1 (MCP-1), neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-beta-D-glucosaminidase, and alpha 1-microglobulin were measured in 40 DTIN subjects, and the performances of these parameters for distinguishing different pathologic lesions were compared.

Results: Linear correlation and receiver operating characteristic curve analyses showed that urinary MCP-1 levels were able to identify serious interstitial edema and inflammatory infiltration with greater accuracy than the other biomarkers (r = 0.501, P < 0.001 and r = 0.768, P < 0.001, respectively), whereas urinary NGAL levels showed the highest correlation coefficient with tubular atrophy (r = 0.692, P < 0.001).

Conclusions: These results suggest that these biomarker levels were higher in patients with DTIN than in controls. Urinary MCP-1 levels correlated and were predictive of the gradated severity of acute lesions in DTIN, whereas the roles of NGAL and alpha 1-microglobulin in chronic alterations require further study. Clin J Am Soc Nephrol 5: 1954-1959, 2010. doi: 10.2215/CJN.02370310

语种英语
所属项目编号2007 BAI04B10
资助者National Key Technologies RD Program ; National Key Technologies RD Program
WOS记录号WOS:000284018500009
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58839
Collection北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
Recommended Citation
GB/T 7714
Wu, Yu,Yang, Li,Su, Tao,et al. Pathological Significance of a Panel of Urinary Biomarkers in Patients with Drug-Induced Tubulointerstitial Nephritis[J]. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,2010,5(11):1954-1959.
APA Wu, Yu,Yang, Li,Su, Tao,Wang, Chen,Liu, Gang,&Li, Xiao-mei.(2010).Pathological Significance of a Panel of Urinary Biomarkers in Patients with Drug-Induced Tubulointerstitial Nephritis.CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,5(11),1954-1959.
MLA Wu, Yu,et al."Pathological Significance of a Panel of Urinary Biomarkers in Patients with Drug-Induced Tubulointerstitial Nephritis".CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 5.11(2010):1954-1959.
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