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A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia
Hu, Zhibin1,2,3; Xia, Yankai1,4,5; Guo, Xuejiang1,6; Dai, Juncheng2,3; Li, HongGang7; Hu, Hongliang8,9; Jiang, Yue2,3; Lu, Feng2,3; Wu, Yibo1,6; Yang, Xiaoyu1,10; Li, Huizhang2,3; Yao, Bing11; Lu, Chuncheng4,5; Xiong, Chenliang7; Li, Zheng8,9; Gui, Yaoting12; Liu, Jiayin1,10; Zhou, Zuomin1,6; Shen, Hongbing1,2,3; Wang, Xinru1,4,5; Sha, Jiahao1,6
刊名NATURE GENETICS
2012-02-01
DOI10.1038/ng.1040
44期:2页:183-186
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
研究领域[WOS]Genetics & Heredity
关键词[WOS]DNA-POLYMERASE-BETA ; BASE-EXCISION-REPAIR ; MALE-INFERTILITY ; SEVERE OLIGOZOOSPERMIA ; ARGININE METHYLATION ; GERM-CELLS ; EXPRESSION ; PROTEIN ; METHYLTRANSFERASE ; SPERMATOGENESIS
英文摘要

Non-obstructive azoospermia (NOA) is one of the most severe forms of male infertility. Its pathophysiology is largely unknown, and few genetic influences have been defined. To identify common variants contributing to NOA in Han Chinese men, we performed a three-stage genome-wide association study of 2,927 individuals with NOA and 5,734 controls. The combined analyses identified significant (P < 5.0 x 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 x 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 x 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 x 10(-9)). These findings implicate genetic variants at 1p13.3, 1p36.32 and 12p12.1 in the etiology of NOA in Han Chinese men.

语种英语
WOS记录号WOS:000299664400017
项目编号2011CB944304 ; 2009AA022705
资助机构National Key Basic Research Program Grant ; China National High-Tech Research and Development Program Grant ; Priority Academic Program Development of Jiangsu Higher Education Institutions
引用统计
被引频次:85[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58840
专题北京大学深圳医院
作者单位1.Nanjing Med Univ, State Key Lab Reprod Med, Nanjing, Jiangsu, Peoples R China
2.Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing, Jiangsu, Peoples R China
3.Nanjing Med Univ, Sch Publ Hlth, Minist Educ, Key Lab Modern Toxicol, Nanjing, Jiangsu, Peoples R China
4.Nanjing Med Univ, Sch Publ Hlth, Dept Toxicol, Nanjing, Jiangsu, Peoples R China
5.Nanjing Med Univ, Sch Publ Hlth, Key Lab Modern Toxicol, Minist Educ, Nanjing, Jiangsu, Peoples R China
6.Nanjing Med Univ, Dept Histol & Embryol, Nanjing, Jiangsu, Peoples R China
7.Huazhong Univ Sci & Technol, Tongji Med Coll, Ctr Reprod Med, Family Planning Res Inst, Wuhan 430074, Peoples R China
8.Shanghai Jiao Tong Univ, Sperm Dev & Genet Lab, Shanghai Human Sperm Bank, Shanghai Inst Androl,Sch Med, Shanghai 200030, Peoples R China
9.Shanghai Jiao Tong Univ, Dept Urol, Renji Hosp, Sch Med, Shanghai 200030, Peoples R China
10.Nanjing Med Univ, Affiliated Hosp 1, Ctr Clin Reprod Med, Nanjing, Jiangsu, Peoples R China
11.Nanjing Jinling Hosp, Dept Androl, Nanjing, Jiangsu, Peoples R China
12.Peking Univ, Shenzhen Hosp, Guangdong Key Lab Male Reprod Med & Genet, Shenzhen, Peoples R China
推荐引用方式
GB/T 7714
Hu, Zhibin,Xia, Yankai,Guo, Xuejiang,et al. A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia[J]. NATURE GENETICS,2012,44(2):183-186.
APA Hu, Zhibin.,Xia, Yankai.,Guo, Xuejiang.,Dai, Juncheng.,Li, HongGang.,...&Sha, Jiahao.(2012).A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.NATURE GENETICS,44(2),183-186.
MLA Hu, Zhibin,et al."A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia".NATURE GENETICS 44.2(2012):183-186.
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