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Decreased production of interleukin-2 (IL-2), IL-2 secreting cells and CD4+cells in medication-free patients with schizophrenia
Zhang, XY; Zhou, DF; Cao, LY; Zhang, PY; Wu, GY
关键词schizophrenia interleukin-2 CD4+cell cytokine immunology
刊名JOURNAL OF PSYCHIATRIC RESEARCH
2002-09-01
36期:5页:331-336
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
研究领域[WOS]Psychiatry
关键词[WOS]INFLAMMATORY RESPONSE SYSTEM ; CEREBROSPINAL-FLUID ; CYTOKINE PRODUCTION ; WHOLE-BLOOD ; DRUG-FREE ; CLOZAPINE ; PSYCHOPATHOLOGY ; NEUROLEPTICS ; HALOPERIDOL ; RESISTANT
英文摘要

There are a number of indications that schizophrenia is associated with changes in the immune system. Although functional studies have mostly demonstrated decreased in vitro production of IL-2 by peripheral blood mononuclear cells (PBMCs) stimulated with mitogen, the reason is unclear. The aim of the study was to explore the relationship between IL-2 production and CD4+ cells which mainly secret IL-2 in non-Caucasian patients with schizophrenia. Blood CD4+ cells and mitogen- stimulated IL-2 secreting cells identified by an immunohistochemical study with the alkaline phosphatase/anti-alkaline phosphatase (APAAP) technique, and in vitro IL-2 production with radioimmunometric assay (RIA) were measured in 30 schizophrenic patients and 30 normal control subjects matched for sex, age and race. The results showed that blood CD4+ cells and mitogen-induced IL-2 secreting cells and IL-2 production were significantly lower in schizophrenic subjects than in the normal controls. There was significantly positive correlation between CB4+ cells and IL-2 production in normal controls but not in patients. These findings suggest that immune disturbance may be present in schizophrenic patients. The lower in vitro IL-2 production is probably related to the decreased number of T-cells that secret IL-2, as well as to the intrinsic disorder of the patients′ T cells. (C) 2002 Elsevier Science Ltd. All rights reserved.

语种英语
WOS记录号WOS:000178254700008
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被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58843
专题北京大学精神卫生研究所
作者单位1.Beijing Hui Long Guan Hosp, Beijing 100096, Peoples R China
2.Peking Univ, Inst Mental Hlth, Sch Med, Beijing 100083, Peoples R China
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GB/T 7714
Zhang, XY,Zhou, DF,Cao, LY,et al. Decreased production of interleukin-2 (IL-2), IL-2 secreting cells and CD4+cells in medication-free patients with schizophrenia[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2002,36(5):331-336.
APA Zhang, XY,Zhou, DF,Cao, LY,Zhang, PY,&Wu, GY.(2002).Decreased production of interleukin-2 (IL-2), IL-2 secreting cells and CD4+cells in medication-free patients with schizophrenia.JOURNAL OF PSYCHIATRIC RESEARCH,36(5),331-336.
MLA Zhang, XY,et al."Decreased production of interleukin-2 (IL-2), IL-2 secreting cells and CD4+cells in medication-free patients with schizophrenia".JOURNAL OF PSYCHIATRIC RESEARCH 36.5(2002):331-336.
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