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学科主题: 口腔医学
题名:
Electrospun PCL/PLA/HA Based Nanofibers as Scaffold for Osteoblast-Like Cells
作者: Fang, Rui1,2; Zhang, Enwei2; Xu, Ling1,2; Wei, Shicheng2,3
关键词: PCL/PLA ; HA ; Osteoblast-Like Cell ; Electrospun ; Bone Tissue Engineering
刊名: JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
发表日期: 2010-11-01
DOI: 10.1166/jnn.2010.2831
卷: 10, 期:11, 页:7747-7751
收录类别: SCI ; ISTP
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]: HYDROXYAPATITE NANOPARTICLES ; CALCIUM PHOSPHATES ; IN-VITRO ; TISSUE ; PROLIFERATION ; CRYSTALLINITY ; MEMBRANES
英文摘要:

Polycaprolactone (PCL), poly (lactic acid) (PLA) and hydroxyapatite (HA) are frequently used as materials for tissue engineering. In this study, PCL/PLA/HA nanofiber mats with different weight ratio were prepared using electrospinning. Their structure and morphology were studied by FTIR and FESEM. FTIR results demonstrated that the HA particles were successfully incorporated into the PCL/PLA nanofibers. The FESEM images showed that the surface of fibers became coarser with the introduction of HA nanoparticles into PCL/PLA system. Furthermore, the addition of HA led to the decreasing of fiber diameter. The average diameters of PCL/PLA/HA nanofiber were in the range of 300-600 nm, while that of PCL/PLA was 776 +/- 15.4 nm. The effect of nanofiber composition on the osteoblast-like MC3T3-E1 cell adhesion and proliferation were investigated as the preliminary biological evaluation of the scaffold. The MC3T3-E1 cell could be attached actively on all the scaffolds. The MU assay revealed that PCL/PLA/HA scaffold shows significantly higher cell proliferation than PCL/PLA scaffolds. After 15 days of culture, mineral particles on the surface of the cells was appeared on PCL/PLA/HA nanofibers while normal cell spreading morphology on PCL/PLA nanofibers. These results manifested that electrospun PCL/PLA/HA scaffolds could enhance bone regeneration, showing their marvelous prospect as scaffolds for bone tissue engineering.

语种: 英语
WOS记录号: WOS:000283621300173
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58844
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Peking Univ, Sch Stomatol, Beijing 100081, Peoples R China
3.Peking Univ, Ctr Biomed Mat & Tissue Engn, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China

Recommended Citation:
Fang, Rui,Zhang, Enwei,Xu, Ling,et al. Electrospun PCL/PLA/HA Based Nanofibers as Scaffold for Osteoblast-Like Cells[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2010,10(11):7747-7751.
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