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学科主题: 基础医学
题名:
Reduction in the in vitro expression of Brain-Pancreas Relative Protein by oxygen and glucose-deprivation
作者: Lin, Yan-Hua; Liu, Ai-Hua; Pan, Yan; Westenbroek, Christel; Ter Horst, Gert J.; Yu, He-Ming; Li, Xue-Jun
关键词: Brain-Pancreas Relative Protein ; oxygen and glucose-deprivation ; reactive oxygen species
刊名: MOLECULAR AND CELLULAR BIOCHEMISTRY
发表日期: 2007
DOI: 10.1007/s11010-006-9289-1
卷: 295, 期:1-2, 页:199-204
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: PHEOCHROMOCYTOMA CELLS ; HYPOXIA ; ISCHEMIA ; INJURY ; MECHANISMS ; APOPTOSIS ; CALCIUM ; CULTURE ; STRESS
英文摘要:

Brain-Pancreas Relative Protein (BPRP) is a novel protein found in our laboratory. In previous study we observed a significant reduction in BPRP in ischemic brain of rat. Here we undertook this study to explore the possible mediating mechanism by which oxygen and glucose-deprivation culture (OGD), a model of ischemia in vitro, decreased the expression of BPRP in PC12 cells. BPRP was found to be expressed in PC12 cells and OGD caused a significant reduction in BPRP expression. The effect of OGD was primarily mediated by reactive oxygen species (ROS) because OGD upregulated the production of ROS and the inhibitors of protein kinase C, calmodulin, free radical scavengers reduced OGD-induced ROS production, while increased the expression of BPRP in PC12 cells. These data indicate that OGD decreases the expression of BPRP via enhanced formation of intracellular ROS.

语种: 英语
WOS记录号: WOS:000243659600023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58846
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
4.Univ Groningen, Univ Med Ctr Groningen, Grad Sch Behav & Cognit Neurosci, Dept Psychiat, NL-9700 RB Groningen, Netherlands
5.Natl Res Inst Family Planning, Beijing 100081, Peoples R China

Recommended Citation:
Lin, Yan-Hua,Liu, Ai-Hua,Pan, Yan,et al. Reduction in the in vitro expression of Brain-Pancreas Relative Protein by oxygen and glucose-deprivation[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY,2007,295(1-2):199-204.
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