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Levels of serum transferrin receptor and its response to Fe-supplement in Fe-deficient children
Lin, Xiao-Ming; Ji, Cheng-Ye; Liu, Wen-Jing; Long, Zhu; Shen, Xiao-Yi
关键词Fe deficiency children serum transferrin receptor Fe supplementation
刊名BRITISH JOURNAL OF NUTRITION
2006-12-01
DOI10.1017/BJN20061954
96期:6页:1134-1139
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]IRON-DEFICIENCY ; DIAGNOSIS ; FERRITIN ; ADULTS ; INDEX ; TOOL
英文摘要

The object of the present study was to investigate the levels of serum transferrin receptor (sTfR) and its response to Fe supplementation in Fe-deficient children and the role of sTfR in detecting Fe deficiency and assessing the efficacy of Fe supplementation. According to the diagnostic standard, 1006 children, aged 6-14 years in Fangshan district, Beijing, Peoples Republic of China, were divided into four groups: normal; Fe store depletion (IDs); Fe deficiency erythropoiesis (IDE); Fe deficiency anaemia (IDA). sTfR was determined and transferrin receptor-ferritin (TfR-F) index was calculated in 238 children, sixty-four normal and 174 Fe deficient. Children were administered a NaFeEDTA capsule containing 60 mg Fe once per week for the IDs and IDE groups and three times per week for the IDA group for nine consecutive weeks. The parameters reflecting Fe status and sTfR were determined before and after Fe supplementation. The levels of sTtR and TfR-F index in Fe-deficient children were significantly higher than those in the normal group. The receiver operating characteristic curve showed that sTfR has proper diagnostic efficacy for functional Fe deficiency. After Fe supplementation, the level of sTfR was significantly decreased in children with IDs, but not in children with IDE and IDA, while TfR-F index was significantly decreased in Fe-deficient children. sTfR is a reliable indicator for detecting functional Fe deficiency, and TfR-F index is a sensitive parameter for assessing the efficacy of Fe supplementation.

语种英语
WOS记录号WOS:000244095600018
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58854
专题北京大学公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Dept Womens Child & Adolescent Hlth, Beijing 100083, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100083, Peoples R China
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GB/T 7714
Lin, Xiao-Ming,Ji, Cheng-Ye,Liu, Wen-Jing,et al. Levels of serum transferrin receptor and its response to Fe-supplement in Fe-deficient children[J]. BRITISH JOURNAL OF NUTRITION,2006,96(6):1134-1139.
APA Lin, Xiao-Ming,Ji, Cheng-Ye,Liu, Wen-Jing,Long, Zhu,&Shen, Xiao-Yi.(2006).Levels of serum transferrin receptor and its response to Fe-supplement in Fe-deficient children.BRITISH JOURNAL OF NUTRITION,96(6),1134-1139.
MLA Lin, Xiao-Ming,et al."Levels of serum transferrin receptor and its response to Fe-supplement in Fe-deficient children".BRITISH JOURNAL OF NUTRITION 96.6(2006):1134-1139.
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