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学科主题: 药物依赖
题名:
Sex- and age-dependent effects of early postnatal sibling deprivation on spatial learning and memory in adult rats
作者: Li, Yan-Qin1; Wang, Xiao-yi1; Zhai, Hai-feng1; Zhang, Xiang Yang2; Kosten, Therese2; Lu, Lin1
关键词: early postnatal sibling deprivation ; development ; spatial learning and memory ; sex ; age
刊名: BEHAVIOURAL BRAIN RESEARCH
发表日期: 2008-01-10
DOI: 10.1016/j.bbr.2007.07.028
卷: 186, 期:1, 页:138-142
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]: PYRAMIDAL NEURON MORPHOLOGY ; FACTOR MESSENGER-RNA ; GUINEA-PIG ; ENVIRONMENTAL ENRICHMENT ; SOCIAL-ISOLATION ; COGNITIVE-DEVELOPMENT ; ENTORHINAL CORTEX ; ISOLATION STRESS ; DENTATE GYRUS ; MATERNAL-CARE
英文摘要:

In this study. we investigated the effects of early postnatal sibling deprivation (EPSD) on spatial learning and memory in adult rats. Litters were culled to one pup with its mother on postnatal day (PN) 1 or 7 and their spatial learning and memory ability were examined with Morris water maze in adult. EPSD on PN1 improved, but on PN7 impaired performance of the spatial learning task in adult female rats. However, EPSD did not have any effect on the spatial learning ability in adult male rats. (c) 2007 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000251869400018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58858
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, VA Med Ctr, Houston, TX 77030 USA

Recommended Citation:
Li, Yan-Qin,Wang, Xiao-yi,Zhai, Hai-feng,et al. Sex- and age-dependent effects of early postnatal sibling deprivation on spatial learning and memory in adult rats[J]. BEHAVIOURAL BRAIN RESEARCH,2008,186(1):138-142.
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