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Sex- and age-dependent effects of early postnatal sibling deprivation on spatial learning and memory in adult rats
Li, Yan-Qin1; Wang, Xiao-yi1; Zhai, Hai-feng1; Zhang, Xiang Yang2; Kosten, Therese2; Lu, Lin1
关键词early postnatal sibling deprivation development spatial learning and memory sex age
刊名BEHAVIOURAL BRAIN RESEARCH
2008-01-10
DOI10.1016/j.bbr.2007.07.028
186期:1页:138-142
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]PYRAMIDAL NEURON MORPHOLOGY ; FACTOR MESSENGER-RNA ; GUINEA-PIG ; ENVIRONMENTAL ENRICHMENT ; SOCIAL-ISOLATION ; COGNITIVE-DEVELOPMENT ; ENTORHINAL CORTEX ; ISOLATION STRESS ; DENTATE GYRUS ; MATERNAL-CARE
英文摘要

In this study. we investigated the effects of early postnatal sibling deprivation (EPSD) on spatial learning and memory in adult rats. Litters were culled to one pup with its mother on postnatal day (PN) 1 or 7 and their spatial learning and memory ability were examined with Morris water maze in adult. EPSD on PN1 improved, but on PN7 impaired performance of the spatial learning task in adult female rats. However, EPSD did not have any effect on the spatial learning ability in adult male rats. (c) 2007 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000251869400018
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58858
专题北京大学第三临床医学院_老年内科
中国药物依赖性研究所
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, VA Med Ctr, Houston, TX 77030 USA
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GB/T 7714
Li, Yan-Qin,Wang, Xiao-yi,Zhai, Hai-feng,et al. Sex- and age-dependent effects of early postnatal sibling deprivation on spatial learning and memory in adult rats[J]. BEHAVIOURAL BRAIN RESEARCH,2008,186(1):138-142.
APA Li, Yan-Qin,Wang, Xiao-yi,Zhai, Hai-feng,Zhang, Xiang Yang,Kosten, Therese,&Lu, Lin.(2008).Sex- and age-dependent effects of early postnatal sibling deprivation on spatial learning and memory in adult rats.BEHAVIOURAL BRAIN RESEARCH,186(1),138-142.
MLA Li, Yan-Qin,et al."Sex- and age-dependent effects of early postnatal sibling deprivation on spatial learning and memory in adult rats".BEHAVIOURAL BRAIN RESEARCH 186.1(2008):138-142.
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