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学科主题基础医学
Gene Decay in Shigella as an Incipient Stage of Host-Adaptation
Feng, Ye1; Chen, Zhe2; Liu, Shu-Lin1,3,4
刊名PLOS ONE
2011-11-16
DOI10.1371/journal.pone.0027754
6期:11
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]ESCHERICHIA-COLI K-12 ; MOLECULAR EVOLUTIONARY HISTORY ; COMPLETE GENOME SEQUENCE ; MAXIMUM-LIKELIHOOD ; FLEXNERI 2A ; DYNAMICS ; PATHOGENICITY ; DIVERSITY ; VIRULENCE ; INSIGHTS
英文摘要

Background: Many facultative bacterial pathogens have undergone extensive gene decay processes, possibly due to lack of selection pressure during evolutionary conversion from free-living to intracellular lifestyle. Shigella, the causative agents of human shigellosis, have arisen from different E. coli-like ancestors independently by convergent paths. As these bacteria all have lost large numbers of genes by mutation or deletion, they can be used as ideal models for systematically studying the process of gene function loss in different bacteria living under similar selection pressures.

Methodologies/Principal Findings: We compared the sequenced Shigella genomes and re-defined decayed genes (pseudogenes plus deleted genes) in these bacteria. Altogether, 85 genes are commonly decayed in the five analyzed Shigella strains and 1456 genes are decayed in at least one Shigella strain. Genes coding for carbon utilization, cell motility, transporter or membrane proteins are prone to be inactivated. Decayed genes tend to concentrate in certain operons rather than distribute averagely across the whole genome. Genes in the decayed operon accumulated more non-synonymous mutations than the rest genes and meanwhile have lower expression levels.

Conclusions: Different Shigella lineages underwent convergent gene decay processes, and inactivation of one gene would lead to a lesser selection pressure for the other genes in the same operon. The pool of superfluous genes for Shigella may contain at least two thousand genes and the gene decay processes may still continue in Shigella until a minimum genome harboring only essential genes is reached.

语种英语
WOS记录号WOS:000297555400105
项目编号NSFC30870098 ; 30970119 ; 81030029 ; 20092307110001
资助机构Harbin Medical University ; National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP)
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58867
专题北京大学基础医学院_病原生物学系
作者单位1.Harbin Med Coll, Genom Res Ctr, Harbin, Peoples R China
2.Univ Calgary, Dept Microbiol & Infect Dis, Calgary, AB, Canada
3.Zhejiang Hosp Tradit Chinese Med, Natl Clin Res Base, Hangzhou, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Feng, Ye,Chen, Zhe,Liu, Shu-Lin. Gene Decay in Shigella as an Incipient Stage of Host-Adaptation[J]. PLOS ONE,2011,6(11).
APA Feng, Ye,Chen, Zhe,&Liu, Shu-Lin.(2011).Gene Decay in Shigella as an Incipient Stage of Host-Adaptation.PLOS ONE,6(11).
MLA Feng, Ye,et al."Gene Decay in Shigella as an Incipient Stage of Host-Adaptation".PLOS ONE 6.11(2011).
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