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学科主题: 基础医学
题名:
Gene Decay in Shigella as an Incipient Stage of Host-Adaptation
作者: Feng, Ye1; Chen, Zhe2; Liu, Shu-Lin1,3,4
刊名: PLOS ONE
发表日期: 2011-11-16
DOI: 10.1371/journal.pone.0027754
卷: 6, 期:11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: ESCHERICHIA-COLI K-12 ; MOLECULAR EVOLUTIONARY HISTORY ; COMPLETE GENOME SEQUENCE ; MAXIMUM-LIKELIHOOD ; FLEXNERI 2A ; DYNAMICS ; PATHOGENICITY ; DIVERSITY ; VIRULENCE ; INSIGHTS
英文摘要:

Background: Many facultative bacterial pathogens have undergone extensive gene decay processes, possibly due to lack of selection pressure during evolutionary conversion from free-living to intracellular lifestyle. Shigella, the causative agents of human shigellosis, have arisen from different E. coli-like ancestors independently by convergent paths. As these bacteria all have lost large numbers of genes by mutation or deletion, they can be used as ideal models for systematically studying the process of gene function loss in different bacteria living under similar selection pressures.

Methodologies/Principal Findings: We compared the sequenced Shigella genomes and re-defined decayed genes (pseudogenes plus deleted genes) in these bacteria. Altogether, 85 genes are commonly decayed in the five analyzed Shigella strains and 1456 genes are decayed in at least one Shigella strain. Genes coding for carbon utilization, cell motility, transporter or membrane proteins are prone to be inactivated. Decayed genes tend to concentrate in certain operons rather than distribute averagely across the whole genome. Genes in the decayed operon accumulated more non-synonymous mutations than the rest genes and meanwhile have lower expression levels.

Conclusions: Different Shigella lineages underwent convergent gene decay processes, and inactivation of one gene would lead to a lesser selection pressure for the other genes in the same operon. The pool of superfluous genes for Shigella may contain at least two thousand genes and the gene decay processes may still continue in Shigella until a minimum genome harboring only essential genes is reached.

语种: 英语
所属项目编号: NSFC30870098 ; 30970119 ; 81030029 ; 20092307110001
项目资助者: Harbin Medical University ; National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP)
WOS记录号: WOS:000297555400105
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58867
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Harbin Med Coll, Genom Res Ctr, Harbin, Peoples R China
2.Univ Calgary, Dept Microbiol & Infect Dis, Calgary, AB, Canada
3.Zhejiang Hosp Tradit Chinese Med, Natl Clin Res Base, Hangzhou, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100871, Peoples R China

Recommended Citation:
Feng, Ye,Chen, Zhe,Liu, Shu-Lin. Gene Decay in Shigella as an Incipient Stage of Host-Adaptation[J]. PLOS ONE,2011,6(11).
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