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学科主题: 临床医学
题名:
Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC
作者: Quan, Cheng1,2,3,4,5; Ren, Yun-Qing1,2,3,4,5; Xiang, Lei-Hong6; Sun, Liang-Dan1,2,3,4,5; Xu, Ai-E4,7; Gao, Xing-Hua8; Chen, Hong-Duo8; Pu, Xiong-Ming4,9; Wu, Ri-Na10; Liang, Chao-Zhao2,3,4,5; Li, Jia-Bin2,3,4,5; Gao, Tian-Wen11; Zhang, Jian-Zhong12; Wang, Xiu-Li4,13; Wang, Jun14; Yang, Rong-Ya4,15; Liang, Ling16; Yu, Jian-Bin17; Zuo, Xian-Bo2,3,4,5; Zhang, Sheng-Quan2,3,4,5; Zhang, Shu-Mei2,3,4,5; Chen, Gang2,3,4,5; Zheng, Xiao-Dong2,3,4,5; Li, Pan2,3,4,5; Zhu, Jun2,3,4,5; Li, Yong-Wei4,7; Wei, Xiao-Dong4,7; Hong, Wei-Song4,7; Ye, Ying6; Zhang, Yong6; Wu, Wei-Su8; Cheng, Hui2,3,4,5; Dong, Pu-Ling2,3,4,5; Hu, Da-Yan2,3,4,5; Li, Yang2,3,4,5; Li, Min2,3,4,5; Zhang, Xin2,3,4,5; Tang, Hua-Yang2,3,4,5; Tang, Xian-Fa2,3,4,5; Xu, Sheng-Xin2,3,4,5; He, Su-Min2,3,4,5; Lv, Yong-Mei2,3,4,5; Shen, Min18; Jiang, Hong-Quan18; Wang, Ying18; Li, Kai11; Kang, Xiao-Jing4,9; Liu, Yu-Qin4,9; Sun, Li10; Liu, Zhi-Fang10; Xie, Shao-Qiong4,13; Zhu, Cheng-Yao2,3,4,5; Xu, Qiang2,3,4,5; Gao, Jin-Ping2,3,4,5; Hu, Wen-Long2,3,4,5; Ni, Cheng2,3,4,5; Pan, Ting-Meng2,3,4,5; Li, Yun2,3,4,5; Yao, Sha2,3,4,5; He, Cai-Feng2,3,4,5; Liu, Yang-Sheng2,3,4,5; Yu, Ze-Ying2,3,4,5; Yin, Xian-Yong2,3,4,5; Zhang, Feng-Yu2,3,4,5; Yang, Sen2,3,4,5; Zhou, Youwen1,2,3,4,5; Zhang, Xue-Jun1,2,3,4,5,6
刊名: NATURE GENETICS
发表日期: 2010-07-01
DOI: 10.1038/ng.603
卷: 42, 期:7, 页:614-U192
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity
研究领域[WOS]: Genetics & Heredity
关键词[WOS]: GENERALIZED VITILIGO ; AUTOIMMUNE-DISEASES ; ROMANIAN POPULATION ; IN-VIVO ; GENE ; HLA ; LINKAGE ; FAMILIES ; FOP ; EPIDEMIOLOGY
英文摘要:

We conducted a genome-wide association study of generalized vitiligo in the Chinese Han population by genotyping 1,117 cases and 1,429 controls. The 34 most promising SNPs were carried forward for replication in samples from individuals of the Chinese Han (5,910 cases and 9,916 controls) and Chinese Uygur (713 cases and 824 controls) populations. We identified two independent association signals within the major histocompatibility complex (MHC) region (rs11966200, P(combined) = 1.48 x 10(-48), OR = 1.90; rs9468925, P(combined) = 2.21 x 10(-33), OR = 0.74). Further analyses suggested that the strong association at rs11966200 might reflect the reported association of the HLA-A*3001, HLA-B*1302, HLA-C*0602 and HLA-DRB1*0701 alleles and that the association at rs9468925 might represent a previously unknown HLA susceptibility allele. We also identified one previously undescribed risk locus at 6q27 (rs2236313, P(combined) = 9.72 x 10(-17), OR = 1.20), which contains three genes: RNASET2, FGFR1OP and CCR6. Our study provides new insights into the genetic basis of vitiligo.

语种: 英语
所属项目编号: 30530670 ; 30628021
项目资助者: Chinese National Natural Science Foundation ; Chinese Key National Natural Science Foundation for Overseas Youth ; Anhui Provincial Special Scientific Program
WOS记录号: WOS:000279242400015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58885
Appears in Collections:北京大学第二临床医学院_皮科_期刊论文

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作者单位: 1.Third Peoples Hosp Hangzhou, Hangzhou, Zhejiang, Peoples R China
2.Shanghai Skin Dis & STD Hosp, Shanghai, Peoples R China
3.Chinese Natl Human Genome Ctr Shanghai, Shanghai, Peoples R China
4.Anhui Med Univ, Hosp 2, Dept Dermatol, Hefei, Anhui, Peoples R China
5.Anhui Med Univ, Hosp 1, Inst Dermatol, Hefei, Anhui, Peoples R China
6.Anhui Med Univ, Hosp 1, Dept Dermatol, Hefei, Anhui, Peoples R China
7.Anhui Med Univ, Dept Dermatol & Venerol, Hefei, Anhui, Peoples R China
8.Anhui Med Univ, Minist Educ, Key Lab Dermatol, Hefei, Anhui, Peoples R China
9.Fudan Univ, Huashan Hosp, Dept Dermatol, Shanghai 200433, Peoples R China
10.China Med Univ, Hosp 1, Dept Dermatol, Shenyang, Liaoning, Peoples R China
11.Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Dermatol, Urumqi, Xinjiang, Peoples R China
12.Inner Mongolia Med Coll, Affiliated Hosp, Dept Dermatol, Hohhot, Inner Mongolia, Peoples R China
13.Fourth Mil Med Univ, Xijing Hosp, Dept Dermatol, Xian 710032, Peoples R China
14.Peking Univ, Peoples Hosp, Dept Dermatol, Beijing 100871, Peoples R China
15.Yijishan Hosp, Wannan Med Coll, Dept Dermatol, Wuhu, Anhui, Peoples R China
16.Beijing Mil Command PLA, Gen Hosp, Dept Dermatol, Beijing, Peoples R China
17.Guangxi Med Univ, Affiliated Hosp 1, Dept Dermatol, Nanning, Guangxi, Peoples R China
18.Zhengzhou Univ, Affiliated Hosp 1, Dept Dermatol, Zhengzhou, Henan, Peoples R China

Recommended Citation:
Quan, Cheng,Ren, Yun-Qing,Xiang, Lei-Hong,et al. Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC[J]. NATURE GENETICS,2010,42(7):614-U192.
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