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学科主题医学信息学
Human MicroRNA Oncogenes and Tumor Suppressors Show Significantly Different Biological Patterns: From Functions to Targets
Wang, Dong1,2; Qiu, Chengxiang1,2; Zhang, Haijun1,2; Wang, Juan1,2; Cui, Qinghua1,2; Yin, Yuxin2,3
刊名PLOS ONE
2010-09-30
DOI10.1371/journal.pone.0013067
5期:9
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者Natural Science Foundation of China ; Natural Science Foundation of China
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]CELL-DEATH ; C-ELEGANS ; EVOLUTION ; CANCER ; DATABASE ; SITES ; APOPTOSIS ; MIRNAS ; LIN-14 ; GENES
英文摘要

MicroRNAs (miRNAs) are small noncoding RNAs which play essential roles in many important biological processes. Therefore, their dysfunction is associated with a variety of human diseases, including cancer. Increasing evidence shows that miRNAs can act as oncogenes or tumor suppressors, and although there is great interest in research into these cancer-associated miRNAs, little is known about them. In this study, we performed a comprehensive analysis of putative human miRNA oncogenes and tumor suppressors. We found that miRNA oncogenes and tumor suppressors clearly show different patterns in function, evolutionary rate, expression, chromosome distribution, molecule size, free energy, transcription factors, and targets. For example, miRNA oncogenes are located mainly in the amplified regions in human cancers, whereas miRNA tumor suppressors are located mainly in the deleted regions. miRNA oncogenes tend to cleave target mRNAs more frequently than miRNA tumor suppressors. These results indicate that these two types of cancer-associated miRNAs play different roles in cancer formation and development. Moreover, the patterns identified here can discriminate novel miRNA oncogenes and tumor suppressors with a high degree of accuracy. This study represents the first large-scale bioinformatic analysis of human miRNA oncogenes and tumor suppressors. Our findings provide help for not only understanding of miRNAs in cancer but also for the specific identification of novel miRNAs as miRNA oncogenes and tumor suppressors. In addition, the data presented in this study will be valuable for the study of both miRNAs and cancer.

语种英语
所属项目编号30900829
资助者Natural Science Foundation of China ; Natural Science Foundation of China
WOS记录号WOS:000282312600016
引用统计
被引频次:79[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58888
专题基础医学院_医学信息学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Biomed Informat, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Inst Syst Biomed, Beijing 100871, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
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GB/T 7714
Wang, Dong,Qiu, Chengxiang,Zhang, Haijun,et al. Human MicroRNA Oncogenes and Tumor Suppressors Show Significantly Different Biological Patterns: From Functions to Targets[J]. PLOS ONE,2010,5(9).
APA Wang, Dong,Qiu, Chengxiang,Zhang, Haijun,Wang, Juan,Cui, Qinghua,&Yin, Yuxin.(2010).Human MicroRNA Oncogenes and Tumor Suppressors Show Significantly Different Biological Patterns: From Functions to Targets.PLOS ONE,5(9).
MLA Wang, Dong,et al."Human MicroRNA Oncogenes and Tumor Suppressors Show Significantly Different Biological Patterns: From Functions to Targets".PLOS ONE 5.9(2010).
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