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学科主题: 临床医学
题名:
Prognostic value of interim F-18-FDG PET/CT in diffuse large B-cell lymphoma
作者: Ying, Zhitao1; Wang, Xuejuan2; Song, Yuqin1; Zheng, Wen1; Wang, Xiaopei1; Xie, Yan1; Lin, Ningjing1; Tu, Meifeng1; Ping, Lingyan1; Liu, Weiping1; Deng, Lijuan1; Zhang, Chen1; Yang, Zhi2; Zhu, Jun1
关键词: Fludeoxyglucose F18 ; lymphoma ; large cell ; diffuse ; prognosis ; standard utility value
刊名: CHINESE JOURNAL OF CANCER RESEARCH
发表日期: 2013-02-01
DOI: 10.3978/j.issn.1000-9604.2013.01.08
卷: 25, 期:1, 页:95-101
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: EMISSION-TOMOGRAPHY SCANS ; NON-HODGKINS-LYMPHOMA ; ELDERLY-PATIENTS ; FDG-PET ; RITUXIMAB ; CHEMOTHERAPY ; TRIAL ; CHOP ; PREDICTOR ; CYCLES
英文摘要:

Objective: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease. The prognostic factor currently used is not accurate enough to predict the outcomes of patients with DLBCL. The prognostic significance of interim PET/CT in DLBCL remains controversial. The aim of this study is to determine the predictive value of interim F-18-FDG PET/CT after first-line treatment in patients with DLBCL.

Methods: Thirty-two patients with DLBCL underwent baseline, interim and post-treatment F-18-FDG PET/CT scans. Imaging results were analyzed for the survival of patients via software SPSS 13.0, retrospectively.

Results: Thirty-one of the 32 patients were treated with R-CHOP regimen, and interim F-18-FDG PET/CT of 24 patients was performed after 2 cycles of treatment. After a median follow-up period of 16.7 months, the 2-year progression-free survival (PFS) rates were significantly different between the groups above and below SUVmax cut-off value of 2.5 (P=0.039). No significant differences were found in the 2-year PFS rates if SUVmax cut-off values were set as 2.0 and 3.0, respectively (P=0.360; P=0.113).

Conclusions: Interim PET/CT could predict the prognosis of DLBCL patients with the SU-V-max cut-off value of 2.5, but more clinical data should be concluded to confirm this conclusion.

语种: 英语
WOS记录号: WOS:000314793300014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58904
Appears in Collections:北京大学临床肿瘤学院_淋巴肿瘤内科_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Dept Lymphoma, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Dept Nucl Med, Canc Hosp & Inst, Beijing 100142, Peoples R China

Recommended Citation:
Ying, Zhitao,Wang, Xuejuan,Song, Yuqin,et al. Prognostic value of interim F-18-FDG PET/CT in diffuse large B-cell lymphoma[J]. CHINESE JOURNAL OF CANCER RESEARCH,2013,25(1):95-101.
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