|Prognostic value of interim F-18-FDG PET/CT in diffuse large B-cell lymphoma|
|Ying, Zhitao1; Wang, Xuejuan2; Song, Yuqin1; Zheng, Wen1; Wang, Xiaopei1; Xie, Yan1; Lin, Ningjing1; Tu, Meifeng1; Ping, Lingyan1; Liu, Weiping1; Deng, Lijuan1; Zhang, Chen1; Yang, Zhi2; Zhu, Jun1|
|关键词||Fludeoxyglucose F18 lymphoma large cell diffuse prognosis standard utility value|
|刊名||CHINESE JOURNAL OF CANCER RESEARCH|
|WOS标题词||Science & Technology|
|关键词[WOS]||EMISSION-TOMOGRAPHY SCANS ; NON-HODGKINS-LYMPHOMA ; ELDERLY-PATIENTS ; FDG-PET ; RITUXIMAB ; CHEMOTHERAPY ; TRIAL ; CHOP ; PREDICTOR ; CYCLES|
Objective: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease. The prognostic factor currently used is not accurate enough to predict the outcomes of patients with DLBCL. The prognostic significance of interim PET/CT in DLBCL remains controversial. The aim of this study is to determine the predictive value of interim F-18-FDG PET/CT after first-line treatment in patients with DLBCL.
Methods: Thirty-two patients with DLBCL underwent baseline, interim and post-treatment F-18-FDG PET/CT scans. Imaging results were analyzed for the survival of patients via software SPSS 13.0, retrospectively.
Results: Thirty-one of the 32 patients were treated with R-CHOP regimen, and interim F-18-FDG PET/CT of 24 patients was performed after 2 cycles of treatment. After a median follow-up period of 16.7 months, the 2-year progression-free survival (PFS) rates were significantly different between the groups above and below SUVmax cut-off value of 2.5 (P=0.039). No significant differences were found in the 2-year PFS rates if SUVmax cut-off values were set as 2.0 and 3.0, respectively (P=0.360; P=0.113).
Conclusions: Interim PET/CT could predict the prognosis of DLBCL patients with the SU-V-max cut-off value of 2.5, but more clinical data should be concluded to confirm this conclusion.
|作者单位||1.Peking Univ, Canc Hosp & Inst, Dept Lymphoma, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China|
2.Peking Univ, Dept Nucl Med, Canc Hosp & Inst, Beijing 100142, Peoples R China
|Ying, Zhitao,Wang, Xuejuan,Song, Yuqin,et al. Prognostic value of interim F-18-FDG PET/CT in diffuse large B-cell lymphoma[J]. CHINESE JOURNAL OF CANCER RESEARCH,2013,25(1):95-101.|
|APA||Ying, Zhitao.,Wang, Xuejuan.,Song, Yuqin.,Zheng, Wen.,Wang, Xiaopei.,...&Zhu, Jun.(2013).Prognostic value of interim F-18-FDG PET/CT in diffuse large B-cell lymphoma.CHINESE JOURNAL OF CANCER RESEARCH,25(1),95-101.|
|MLA||Ying, Zhitao,et al."Prognostic value of interim F-18-FDG PET/CT in diffuse large B-cell lymphoma".CHINESE JOURNAL OF CANCER RESEARCH 25.1(2013):95-101.|