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Prognostic value of interim F-18-FDG PET/CT in diffuse large B-cell lymphoma
Ying, Zhitao1; Wang, Xuejuan2; Song, Yuqin1; Zheng, Wen1; Wang, Xiaopei1; Xie, Yan1; Lin, Ningjing1; Tu, Meifeng1; Ping, Lingyan1; Liu, Weiping1; Deng, Lijuan1; Zhang, Chen1; Yang, Zhi2; Zhu, Jun1
关键词Fludeoxyglucose F18 lymphoma large cell diffuse prognosis standard utility value
刊名CHINESE JOURNAL OF CANCER RESEARCH
2013-02-01
DOI10.3978/j.issn.1000-9604.2013.01.08
25期:1页:95-101
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]EMISSION-TOMOGRAPHY SCANS ; NON-HODGKINS-LYMPHOMA ; ELDERLY-PATIENTS ; FDG-PET ; RITUXIMAB ; CHEMOTHERAPY ; TRIAL ; CHOP ; PREDICTOR ; CYCLES
英文摘要

Objective: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease. The prognostic factor currently used is not accurate enough to predict the outcomes of patients with DLBCL. The prognostic significance of interim PET/CT in DLBCL remains controversial. The aim of this study is to determine the predictive value of interim F-18-FDG PET/CT after first-line treatment in patients with DLBCL.

Methods: Thirty-two patients with DLBCL underwent baseline, interim and post-treatment F-18-FDG PET/CT scans. Imaging results were analyzed for the survival of patients via software SPSS 13.0, retrospectively.

Results: Thirty-one of the 32 patients were treated with R-CHOP regimen, and interim F-18-FDG PET/CT of 24 patients was performed after 2 cycles of treatment. After a median follow-up period of 16.7 months, the 2-year progression-free survival (PFS) rates were significantly different between the groups above and below SUVmax cut-off value of 2.5 (P=0.039). No significant differences were found in the 2-year PFS rates if SUVmax cut-off values were set as 2.0 and 3.0, respectively (P=0.360; P=0.113).

Conclusions: Interim PET/CT could predict the prognosis of DLBCL patients with the SU-V-max cut-off value of 2.5, but more clinical data should be concluded to confirm this conclusion.

语种英语
WOS记录号WOS:000314793300014
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58904
专题北京大学临床肿瘤学院_淋巴肿瘤内科
北京大学临床肿瘤学院_核医学科
作者单位1.Peking Univ, Canc Hosp & Inst, Dept Lymphoma, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Dept Nucl Med, Canc Hosp & Inst, Beijing 100142, Peoples R China
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Ying, Zhitao,Wang, Xuejuan,Song, Yuqin,et al. Prognostic value of interim F-18-FDG PET/CT in diffuse large B-cell lymphoma[J]. CHINESE JOURNAL OF CANCER RESEARCH,2013,25(1):95-101.
APA Ying, Zhitao.,Wang, Xuejuan.,Song, Yuqin.,Zheng, Wen.,Wang, Xiaopei.,...&Zhu, Jun.(2013).Prognostic value of interim F-18-FDG PET/CT in diffuse large B-cell lymphoma.CHINESE JOURNAL OF CANCER RESEARCH,25(1),95-101.
MLA Ying, Zhitao,et al."Prognostic value of interim F-18-FDG PET/CT in diffuse large B-cell lymphoma".CHINESE JOURNAL OF CANCER RESEARCH 25.1(2013):95-101.
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