IR@PKUHSC  > 北京大学公共卫生学院
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Seroepidemiology of hepatitis B virus infection in 2 million men aged 21-49 years in rural China: a population-based, cross-sectional study
Liu, Jue1; Zhang, Shikun2; Wang, Qiaomei2; Shen, Haiping2; Zhang, Man3; Zhang, Yiping2; Yan, Donghai2; Liu, Min1
刊名LANCET INFECTIOUS DISEASES
2016
DOI10.1016/S1473-3099(15)00218-2
16期:1页:80-86
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases
研究领域[WOS]Infectious Diseases
关键词[WOS]GLOBAL BURDEN ; RISK-FACTORS ; PREVALENCE ; VACCINATION ; EPIDEMIOLOGY ; ANTIGEN ; DISEASE ; REGION ; AREAS ; WOMEN
英文摘要

Background Hepatitis B virus (HBV) infection is highly endemic (7-8% prevalence) in rural China, causing high mortality and societal burden. Data from men of reproductive age is scarce and last reported in 2006. We assessed the seroepidemiology of men in rural China, aiming to provide updated baseline data for the prevalence of HBV infection.

Methods We established prevalence of HBV infection from data gathered through a nationwide population-based study of Chinese rural men aged 21-49 years. Data were obtained from a physical check-up programme for couples of reproductive age, the National Free Preconception Health Examination Project, that covered 31 provinces from 2010-12. We tested serological samples with ELISA and categorised participants′ HBV status based on presence of HBsAg, anti-HBV core antibody (anti-HBc), and anti-HBV surface antibody (anti-HBs).

Findings 2 030 083 men were recruited into the database from Jan 1, 2010, to Dec 31, 2012, and 1 966 013 men provided serum samples for analysis. 124 274 men (6%) tested positive for HBsAg, 178 559 (9%) tested positive for anti-HBc, and 583 923 (30%) tested positive for anti-HBs. Isolated anti-HBs (an indicator of vaccine-mediated immunity) were present in 527 566 men (27%). And 1 234 127 men (63%) were negative for all HBV makers (susceptible population). HBsAg prevalence was higher in men aged 25-39 years (6.35-6.47%) than in other age groups (5.54-5.78%; p<0.0001). HBV markers were all more prevalent in the eastern region of China than in the central or western regions (all p<0.0001). 32 326 (26%) of 124 274 HBsAg-positive men tested positive for HBeAg (suggesting high infectiousness); this decreased with increasing age (p<0.0001).

Interpretation HBV prevalence in men in rural China has changed from highly endemic into intermediate endemic in the past two decades. However, the absolute number of HBV-infected men and the susceptible population is still very large.

语种英语
WOS记录号WOS:000366664900036
资助机构Chinese Association of Maternal and Child Health Studies
引用统计
被引频次:44[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58907
专题北京大学公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
2.Natl Hlth & Family Planning Commiss PRC, Dept Maternal & Child Hlth, Beijing, Peoples R China
3.Capital Med Univ, Beijing Shijitan Hosp, Ctr Clin Lab, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Liu, Jue,Zhang, Shikun,Wang, Qiaomei,et al. Seroepidemiology of hepatitis B virus infection in 2 million men aged 21-49 years in rural China: a population-based, cross-sectional study[J]. LANCET INFECTIOUS DISEASES,2016,16(1):80-86.
APA Liu, Jue.,Zhang, Shikun.,Wang, Qiaomei.,Shen, Haiping.,Zhang, Man.,...&Liu, Min.(2016).Seroepidemiology of hepatitis B virus infection in 2 million men aged 21-49 years in rural China: a population-based, cross-sectional study.LANCET INFECTIOUS DISEASES,16(1),80-86.
MLA Liu, Jue,et al."Seroepidemiology of hepatitis B virus infection in 2 million men aged 21-49 years in rural China: a population-based, cross-sectional study".LANCET INFECTIOUS DISEASES 16.1(2016):80-86.
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