IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Neural (N-) cadherin, a synaptic adhesion molecule, is induced in hippocampal mossy fiber axonal sprouts by seizure
Shan, WS; Yoshida, M; Wu, XR; Huntley, GW; Colman, DR
关键词N-cadherin cell adhesion molecule synaptogenesis epilepsy mossy fiber
刊名JOURNAL OF NEUROSCIENCE RESEARCH
2002-08-01
DOI10.1002/jnr.10305
69期:3页:292-304
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CENTRAL-NERVOUS-SYSTEM ; GRANULE CELL NEUROGENESIS ; TEMPORAL-LOBE EPILEPSY ; LONG-TERM POTENTIATION ; ADULT-RAT HIPPOCAMPUS ; DENTATE GYRUS ; STATUS EPILEPTICUS ; NEURITE OUTGROWTH ; NEUROTROPHIC FACTOR ; ENTORHINAL CORTEX
英文摘要

Aberrant mossy fiber sprouting and synaptic reorganization are plastic responses in human temporal lobe epilepsy, and in pilocarpine-induced epilepsy in rodents. Although the morphological features of the hippocampal epileptic reaction have been well documented, the molecular mechanisms underlying these structural changes are not understood. The classic cadherins, calcium-dependent cell adhesion molecules, are known to function in development in neurite outgrowth, synapse formation, and stabilization. In pilocarpine-incluced status epilepticus, the expression of N-cadherin mRNA was sharply upregulated and reached a maximum level (1- to 2.5-fold) at 1- to 4 weeks postseizure in the granule cell layer and the pyramidal cell layer of CA3. N-cadherin protein was correspondingly increased and became concentrated in the inner molecular layer of the dentate gyrus, consistent with the position of mossy fiber axonal sprouts. Moreover, N-cadherin labeling was punctate; colocalized with definitive synaptic markers, and partially localized on polysialated forms of neural cell adhesion molecule (PSA-NCAM)-positive dendrites of granule cells in the inner molecular layer. Our findings show that N-cadherin is likely to be a key factor in responsive synaptogenesis following status epilepticus, where it functions as a mediator of de novo synapse formation. (C) 2002 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000177064000003
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58912
专题北京大学第一临床医学院
作者单位1.Mt Sinai Sch Med, Fishberg Res Ctr Neurobiol, New York, NY 10029 USA
2.Mt Sinai Sch Med, Corinne Goldsmith Dickinson Ctr Multiple Sclerosi, New York, NY 10029 USA
3.Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA
4.Mt Sinai Sch Med, Dept Biochem, New York, NY 10029 USA
5.Mt Sinai Sch Med, Dept Mol Biol, New York, NY 10029 USA
6.Beijing Univ, Hosp 1, Dept Child Neurol, Beijing 100871, Peoples R China
7.Tohoku Univ, Sch Med, Dept Cell Biol, Div Histol, Sendai, Miyagi 980, Japan
推荐引用方式
GB/T 7714
Shan, WS,Yoshida, M,Wu, XR,et al. Neural (N-) cadherin, a synaptic adhesion molecule, is induced in hippocampal mossy fiber axonal sprouts by seizure[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2002,69(3):292-304.
APA Shan, WS,Yoshida, M,Wu, XR,Huntley, GW,&Colman, DR.(2002).Neural (N-) cadherin, a synaptic adhesion molecule, is induced in hippocampal mossy fiber axonal sprouts by seizure.JOURNAL OF NEUROSCIENCE RESEARCH,69(3),292-304.
MLA Shan, WS,et al."Neural (N-) cadherin, a synaptic adhesion molecule, is induced in hippocampal mossy fiber axonal sprouts by seizure".JOURNAL OF NEUROSCIENCE RESEARCH 69.3(2002):292-304.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Shan, WS]的文章
[Yoshida, M]的文章
[Wu, XR]的文章
百度学术
百度学术中相似的文章
[Shan, WS]的文章
[Yoshida, M]的文章
[Wu, XR]的文章
必应学术
必应学术中相似的文章
[Shan, WS]的文章
[Yoshida, M]的文章
[Wu, XR]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。