IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Neural (N-) cadherin, a synaptic adhesion molecule, is induced in hippocampal mossy fiber axonal sprouts by seizure
Shan, WS; Yoshida, M; Wu, XR; Huntley, GW; Colman, DR
关键词N-cadherin cell adhesion molecule synaptogenesis epilepsy mossy fiber
刊名JOURNAL OF NEUROSCIENCE RESEARCH
2002-08-01
DOI10.1002/jnr.10305
69期:3页:292-304
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CENTRAL-NERVOUS-SYSTEM ; GRANULE CELL NEUROGENESIS ; TEMPORAL-LOBE EPILEPSY ; LONG-TERM POTENTIATION ; ADULT-RAT HIPPOCAMPUS ; DENTATE GYRUS ; STATUS EPILEPTICUS ; NEURITE OUTGROWTH ; NEUROTROPHIC FACTOR ; ENTORHINAL CORTEX
英文摘要

Aberrant mossy fiber sprouting and synaptic reorganization are plastic responses in human temporal lobe epilepsy, and in pilocarpine-induced epilepsy in rodents. Although the morphological features of the hippocampal epileptic reaction have been well documented, the molecular mechanisms underlying these structural changes are not understood. The classic cadherins, calcium-dependent cell adhesion molecules, are known to function in development in neurite outgrowth, synapse formation, and stabilization. In pilocarpine-incluced status epilepticus, the expression of N-cadherin mRNA was sharply upregulated and reached a maximum level (1- to 2.5-fold) at 1- to 4 weeks postseizure in the granule cell layer and the pyramidal cell layer of CA3. N-cadherin protein was correspondingly increased and became concentrated in the inner molecular layer of the dentate gyrus, consistent with the position of mossy fiber axonal sprouts. Moreover, N-cadherin labeling was punctate; colocalized with definitive synaptic markers, and partially localized on polysialated forms of neural cell adhesion molecule (PSA-NCAM)-positive dendrites of granule cells in the inner molecular layer. Our findings show that N-cadherin is likely to be a key factor in responsive synaptogenesis following status epilepticus, where it functions as a mediator of de novo synapse formation. (C) 2002 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000177064000003
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58912
Collection北京大学第一临床医学院
作者单位1.Mt Sinai Sch Med, Fishberg Res Ctr Neurobiol, New York, NY 10029 USA
2.Mt Sinai Sch Med, Corinne Goldsmith Dickinson Ctr Multiple Sclerosi, New York, NY 10029 USA
3.Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA
4.Mt Sinai Sch Med, Dept Biochem, New York, NY 10029 USA
5.Mt Sinai Sch Med, Dept Mol Biol, New York, NY 10029 USA
6.Beijing Univ, Hosp 1, Dept Child Neurol, Beijing 100871, Peoples R China
7.Tohoku Univ, Sch Med, Dept Cell Biol, Div Histol, Sendai, Miyagi 980, Japan
Recommended Citation
GB/T 7714
Shan, WS,Yoshida, M,Wu, XR,et al. Neural (N-) cadherin, a synaptic adhesion molecule, is induced in hippocampal mossy fiber axonal sprouts by seizure[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2002,69(3):292-304.
APA Shan, WS,Yoshida, M,Wu, XR,Huntley, GW,&Colman, DR.(2002).Neural (N-) cadherin, a synaptic adhesion molecule, is induced in hippocampal mossy fiber axonal sprouts by seizure.JOURNAL OF NEUROSCIENCE RESEARCH,69(3),292-304.
MLA Shan, WS,et al."Neural (N-) cadherin, a synaptic adhesion molecule, is induced in hippocampal mossy fiber axonal sprouts by seizure".JOURNAL OF NEUROSCIENCE RESEARCH 69.3(2002):292-304.
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