|Depression, anxiety, and prevalent diabetes in the Chinese population: Findings from the China Kadoorie Biobank of 0.5 million people|
|Mezuk, Briana1,2; Chen, Yiping3,4; Yu, Canqing3,4,5; Guo, Yu6; Bian, Zheng6; Collins, Rory3,4; Chen, Junshi7; Pang, Zengchang8; Wang, Huijun; Peto, Richard3,4; Que, Xiangsan; Zhang, Hui; Tan, Zhongwen9; Kendler, Kenneth S.2; Li, Liming5,6; Chen, Zhengming3,4|
|关键词||Anxiety Culture Depression Epidemiology Type 2 diabetes|
|刊名||JOURNAL OF PSYCHOSOMATIC RESEARCH|
|收录类别||SCI ; SSCI|
|WOS标题词||Science & Technology|
|关键词[WOS]||WORLD-HEALTH-ORGANIZATION ; MENTAL-DISORDERS ; METROPOLITAN CHINA ; SYMPTOMS ; METAANALYSIS ; ASSOCIATION ; OBESITY ; RISK ; NUTRITION ; INCREASE|
Objective: Despite previous investigation, uncertainty remains about the nature of the associations of major depression (MD) with type 2 diabetes mellitus (T2DM), particularly in adult Chinese, and the relevance of generalized anxiety disorder (GAD) for T2DM.
Methods: Cross-sectional data from the China Kadoorie Biobank Study, a sample of approximately 500,000 adults from 10 geographically defined regions of China, were analyzed. Past year MD and GAD were assessed using the Composite International Diagnostic Inventory. T2DM was defined as either having self-reported physician diagnosis of diabetes at age 30 or later ("clinically-identified" cases) or having a non-fasting blood glucose >= 11.1 mmol/L or fasting blood glucose >= 7.0 mmol/L but no prior diagnosis of diabetes ("screen-detected" cases). Logistic regression was used to assess the relationship between MD and GAD with clinically-identified and screen-detected T2DM, adjusting for demographic characteristics and health behaviors.
Results: The prevalence of T2DM was 53% (3.2% clinically-identified and 2.1% screen-detected). MD was significantly associated with clinically-identified T2DM (odds ratio [OR]: 1.75,95% confidence interval (CI): 1.47-2.08), but not with screen-detected T2DM (OR: 1.18,95% CI: 0.92-1.51). GAD was associated with clinically-identified (OR: 2.14,95% CI: 1.60-2.88) and modestly associated with screen-detected (OR: 1.44,95% CI: 0.99-2.08) T2DM. The relationship between MD and GAD with T2DM was moderated by obesity.
Conclusion: MD is associated with clinically-identified, but not screen-detected T2DM. GAD is associated with both clinically-identified and screen-detected T2DM. The relationship between MD and T2DM is strongest among those who are not obese. (c) 2013 Elsevier Inc. All rights reserved.
|项目编号||088158/Z/09/Z ; 2011BAI09B01 ; K01-MH093642-A1 ; R21-DK8356430-A1 ; 81202266|
|资助机构||Kadoorie Charitable Foundation in Hong Kong ; Wellcome Trust in the UK ; Chinese Ministry of Science and Technology ; UK Medical Research Council ; British Heart Foundation ; Cancer Research UK ; National Institute of Health ; National Natural Science Foundation of China ; Sino-British Friendship Fellowship scheme|
|作者单位||1.China Natl Ctr Food Safety Risk Assessment, Beijing, Peoples R China|
2.Qingdao CDC, Qingdao, Peoples R China
3.Virginia Commonwealth Univ, Dept Family Med & Populat Hlth, Div Epidemiol, Richmond, VA 23238 USA
4.Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Richmond, VA USA
5.Univ Oxford, Nuffield Dept Clin Med, Clin Trial Serv Unit, Oxford OX1 2JD, England
6.Univ Oxford, Nuffield Dept Clin Med, Epidemiol Studies Unit, Oxford OX1 2JD, England
7.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China
8.Chinese Acad Med Sci, Beijing 100730, Peoples R China
9.Liuyang CDC, NCDs Prevent & Control Dept, Changsha, Hunan, Peoples R China
|Mezuk, Briana,Chen, Yiping,Yu, Canqing,et al. Depression, anxiety, and prevalent diabetes in the Chinese population: Findings from the China Kadoorie Biobank of 0.5 million people[J]. JOURNAL OF PSYCHOSOMATIC RESEARCH,2013,75(6):511-517.|
|APA||Mezuk, Briana.,Chen, Yiping.,Yu, Canqing.,Guo, Yu.,Bian, Zheng.,...&Chen, Zhengming.(2013).Depression, anxiety, and prevalent diabetes in the Chinese population: Findings from the China Kadoorie Biobank of 0.5 million people.JOURNAL OF PSYCHOSOMATIC RESEARCH,75(6),511-517.|
|MLA||Mezuk, Briana,et al."Depression, anxiety, and prevalent diabetes in the Chinese population: Findings from the China Kadoorie Biobank of 0.5 million people".JOURNAL OF PSYCHOSOMATIC RESEARCH 75.6(2013):511-517.|