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学科主题: 口腔医学
题名:
Elevated Plasma Calcifediol Is Associated With Aggressive Periodontitis
作者: Liu, Kaining; Meng, Huanxin; Tang, Xiaolin; Xu, Li; Zhang, Li; Chen, Zhibin; Shi, Dong; Feng, Xianghui; Lu, Ruifang
关键词: Aggressive periodontitis ; alkaline phosphatase ; calcifediol ; calcium ; osteocalcin ; phosphorus
刊名: JOURNAL OF PERIODONTOLOGY
发表日期: 2009-07-01
DOI: 10.1902/jop.2009.080675
卷: 80, 期:7, 页:1114-1120
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: VITAMIN-D-RECEPTOR ; TOOTH LOSS ; SERUM CONCENTRATIONS ; GENE POLYMORPHISM ; D DEFICIENCY ; POPULATION ; DISEASE ; CALCITRIOL ; CALCIUM ; ANALOGS
英文摘要:

Background: Vitamin D is associated with a number of inflammatory diseases and plays a significant role in regulating bone metabolism. Serum calcifediol was demonstrated to be potentially associated with periodontal disease. The purpose of this study was to evaluate whether an association exists between plasma calcifediol concentrations and aggressive periodontitis (AgP) and whether plasma levels of bone-related biomarkers (osteocalcin, alkaline phosphatase, calcium, and phosphorus) regulated by vitamin D are related to AgP.

Methods: Sixty-six patients with generalized AgP, 52 patients with chronic periodontitis, and 60 healthy controls were included in this study. Periodontal examination consisted of probing depth, attachment loss, and bleeding index measurements. Hematic calcifediol and bone-related biomarker levels were detected using radioimmunity assay kits or a biochemical analyzer.

Results: Plasma calcifediol levels in patients with AgP were higher than those of healthy controls (29.28 versus 21.60 nmol/l; P<0.05) and were statistically significantly correlated with bleeding index (r = 0.321; P<0.05). Plasma osteocalcin concentrations in patients with AgP were higher than those of healthy controls (0.90 versus 0.70 ng/ml; P<0.05). Serum inorganic phosphorus values of both periodontitis groups were lower than those of healthy controls (1.06 +/- 0.18 mmol/l and 1.10 +/- 0.15 mmol/l versus 1.26 +/- 0.17 mmol/l; P<0.05).

Conclusion: Plasma calcifediol levels might be associated with periodontal inflammation. J Periodontol 2009;80:1114-1120.

语种: 英语
所属项目编号: 30471882 ; 30772420 ; 2007BAZ18B02
项目资助者: National Natural Science Foundations of China, Beijing, China ; National Key Project of Scientific and Technical Supporting Programs of China, Beijing, China
WOS记录号: WOS:000268042100015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58925
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: Peking Univ, Dept Periodontol, Sch & Hosp Stomatol, Beijing 100081, Peoples R China

Recommended Citation:
Liu, Kaining,Meng, Huanxin,Tang, Xiaolin,et al. Elevated Plasma Calcifediol Is Associated With Aggressive Periodontitis[J]. JOURNAL OF PERIODONTOLOGY,2009,80(7):1114-1120.
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