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学科主题: 临床医学
题名:
Prognostic Significance of Downregulated Expression of Programmed Cell Death 5 in Chondrosarcoma
作者: Chen, Changbao1; Zhou, Hua1; Xu, Lanjun2,3; Liu, Xiaoguang1; Liu, Zhongjun1; Ma, Dalong2,3; Chen, Yingyu2,3; Ma, Qingjun1
关键词: Programmed Cell Death 5 ; prognostic significance ; chondrosarcoma
刊名: JOURNAL OF SURGICAL ONCOLOGY
发表日期: 2010-12-01
DOI: 10.1002/jso.21730
卷: 102, 期:7, 页:838-843
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Surgery
研究领域[WOS]: Oncology ; Surgery
关键词[WOS]: TUMOR-CELLS ; APOPTOSIS ; PDCD5 ; BONE ; GENE ; LEUKEMIA ; OVEREXPRESSION ; SARCOMA ; TFAR19
英文摘要:

Background and Objectives: Programmed Cell Death 5 (PDCD5) is a novel apoptosis-related gene and deregulation of PDCD5 is involved in tumorigenicity. This study was designed to investigate the expression level of PDCD5 and to clarify its clinical significance in chondrosarcoma.

Methods: The mRNA and protein levels of PDCD5 in chondrosarcoma and matched corresponding non-tumor tissues were evaluated by real-time PCR and Western blot. respectively. The expression of PDCD5 protein was investigated by immunohistochemistry assays in chondrosarcoma, and its association with clinicopathologic factors and overall survival was also analyzed.

Results: The mRNA and protein levels of PDCD5 were significantly decreased in chondrosarcoma compared with corresponding non-tumor tissues. Low expression of PDCD5 protein was 61.8% (21/34) in chondrosarcomas, as compared 12.5% (1/8) in normal bones, as well as compared 23.5% (4/17) in benign cartilage tumors. PDCD5 expression was correlated with anatomical location and histological grade. The survival rate of patients with low-PDCD5 tumors was lower than that of patients with high-PDCD5 tumors. Multivariate analysis revealed that the downregulated expression of PDCD5 was an independent prognostic factor for overall survival.

Conclusions: PDCD5 is downregulated in chondrosarcoma and might be an independent prognostic factor for overall survival of chondrosarcoma patients. J. Surg. Oncol, 2010;102:838-843. (C)2010 Wiley-Liss, Inc.

语种: 英语
所属项目编号: 30871263 ; 30571870 ; 2009ZX09102-242 ; 2006AA02A305
项目资助者: National Natural Sciences Foundation of China ; National Key New Drug Creation Program of China ; National High Technology Research and Development Program of China
WOS记录号: WOS:000285281300025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58927
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

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作者单位: 1.Peking Univ, Dept Orthopaed Surg, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Lab Med Immunol, Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China

Recommended Citation:
Chen, Changbao,Zhou, Hua,Xu, Lanjun,et al. Prognostic Significance of Downregulated Expression of Programmed Cell Death 5 in Chondrosarcoma[J]. JOURNAL OF SURGICAL ONCOLOGY,2010,102(7):838-843.
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