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Prognostic Significance of Downregulated Expression of Programmed Cell Death 5 in Chondrosarcoma
Chen, Changbao1; Zhou, Hua1; Xu, Lanjun2,3; Liu, Xiaoguang1; Liu, Zhongjun1; Ma, Dalong2,3; Chen, Yingyu2,3; Ma, Qingjun1
关键词Programmed Cell Death 5 prognostic significance chondrosarcoma
刊名JOURNAL OF SURGICAL ONCOLOGY
2010-12-01
DOI10.1002/jso.21730
102期:7页:838-843
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Surgery
资助者National Natural Sciences Foundation of China ; National Key New Drug Creation Program of China ; National High Technology Research and Development Program of China ; National Natural Sciences Foundation of China ; National Key New Drug Creation Program of China ; National High Technology Research and Development Program of China
研究领域[WOS]Oncology ; Surgery
关键词[WOS]TUMOR-CELLS ; APOPTOSIS ; PDCD5 ; BONE ; GENE ; LEUKEMIA ; OVEREXPRESSION ; SARCOMA ; TFAR19
英文摘要

Background and Objectives: Programmed Cell Death 5 (PDCD5) is a novel apoptosis-related gene and deregulation of PDCD5 is involved in tumorigenicity. This study was designed to investigate the expression level of PDCD5 and to clarify its clinical significance in chondrosarcoma.

Methods: The mRNA and protein levels of PDCD5 in chondrosarcoma and matched corresponding non-tumor tissues were evaluated by real-time PCR and Western blot. respectively. The expression of PDCD5 protein was investigated by immunohistochemistry assays in chondrosarcoma, and its association with clinicopathologic factors and overall survival was also analyzed.

Results: The mRNA and protein levels of PDCD5 were significantly decreased in chondrosarcoma compared with corresponding non-tumor tissues. Low expression of PDCD5 protein was 61.8% (21/34) in chondrosarcomas, as compared 12.5% (1/8) in normal bones, as well as compared 23.5% (4/17) in benign cartilage tumors. PDCD5 expression was correlated with anatomical location and histological grade. The survival rate of patients with low-PDCD5 tumors was lower than that of patients with high-PDCD5 tumors. Multivariate analysis revealed that the downregulated expression of PDCD5 was an independent prognostic factor for overall survival.

Conclusions: PDCD5 is downregulated in chondrosarcoma and might be an independent prognostic factor for overall survival of chondrosarcoma patients. J. Surg. Oncol, 2010;102:838-843. (C)2010 Wiley-Liss, Inc.

语种英语
所属项目编号30871263 ; 30571870 ; 2009ZX09102-242 ; 2006AA02A305
资助者National Natural Sciences Foundation of China ; National Key New Drug Creation Program of China ; National High Technology Research and Development Program of China ; National Natural Sciences Foundation of China ; National Key New Drug Creation Program of China ; National High Technology Research and Development Program of China
WOS记录号WOS:000285281300025
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58927
专题北京大学第三临床医学院_骨科
作者单位1.Peking Univ, Dept Orthopaed Surg, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Lab Med Immunol, Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Chen, Changbao,Zhou, Hua,Xu, Lanjun,et al. Prognostic Significance of Downregulated Expression of Programmed Cell Death 5 in Chondrosarcoma[J]. JOURNAL OF SURGICAL ONCOLOGY,2010,102(7):838-843.
APA Chen, Changbao.,Zhou, Hua.,Xu, Lanjun.,Liu, Xiaoguang.,Liu, Zhongjun.,...&Ma, Qingjun.(2010).Prognostic Significance of Downregulated Expression of Programmed Cell Death 5 in Chondrosarcoma.JOURNAL OF SURGICAL ONCOLOGY,102(7),838-843.
MLA Chen, Changbao,et al."Prognostic Significance of Downregulated Expression of Programmed Cell Death 5 in Chondrosarcoma".JOURNAL OF SURGICAL ONCOLOGY 102.7(2010):838-843.
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